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ACAT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ACAT1 38

    Alternate Names:

    38
    ACETYL-COA ACETYLTRANSFERASE 1
    ACAT1
    ACAT
    MAT
    T2
    THIL
    607809
    93
    ENSG00000075239
    OTTHUMG00000166381
    P24752
    THIL_HUMAN
    ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL
    ACETOACETYL-COA THIOLASE
    BE0000069
    T11487
    2435
    NP_000010
    NM_000019

    Gene Info:

    Target Subclass 2.3.1.9
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:2.3.1.9
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Lanosterol biosynthesis pathway
    GuideToPharmacology Gene Category ID 104
    (4 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
  • SULFASALAZINE   ACAT1

    Interaction Score: 3.92

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target

    PMIDs:
    17139284 17016423 1357724


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CANNABIDIOL   ACAT1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   ACAT1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • Ensembl: ENSG00000075239

    • Version: 101_38

    Alternate Names:
    ACAT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P24752

    • Version: January-2014

    Alternate Names:
    ACAT1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.3.1.9

    Publications:

  • TEND: P24752

    • Version: 01-August-2011

    Alternate Names:
    38 Entrez Gene Id
    P24752 Uniprot Accession
    ACAT1 Gene Symbol

    Gene Info:
    Target Subclass 2.3.1.9
    Target Main Class Enzymes

    Publications:

  • GuideToPharmacology: 38

    • Version: 29-September-2020

    Alternate Names:
    93 HUGO Gene ID
    93 HUGO Gene Symbol
    acetyl-CoA acetyltransferase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Lanosterol biosynthesis pathway
    GuideToPharmacology Gene Category ID 104

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0000069

    • Version: 5.1.7

    Alternate Names:
    ACAT1 DrugBank Gene Name
    P24752 UniProt Accession
    38 Entrez Gene Id

    Gene Info:

    Publications:
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Faison et al., 1992, Sulfasalazine inhibits lyso-PAF: acetyl-COA acetyltransferase., Prostaglandins

  • HumanProteinAtlas: ACAT1

    • Version: 19.3

    Alternate Names:
    ENSG00000075239 Ensembl Gene ID
    ACAT Human Protein Atlas Gene Synonym
    THIL Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: ACAT1

    • Version: 03-September-2020

    Alternate Names:
    Acetyl-CoA acetyltransferase, mitochondrial Gene Name
    P24752 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Acetoacetyl-CoA thiolase

    • Version: 2020.06.01

    Alternate Names:
    ACAT1 TTD Gene Abbreviation
    T11487 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21