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ADA Gene Record

  • Summary
  • Interactions
  • Claims
  • ADA 100 Druggable Genome

    Alternate Names:

    100
    ADENOSINE DEAMINASE
    ADA
    608958
    186
    ENSG00000196839
    OTTHUMG00000033081
    P00813
    ADENOSINE DEAMINASE (EC 3.5.4.4) (ADENOSINE AMINOHYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00813]
    ADA1
    ADA_HUMAN
    Adenosine aminohydrolase
    T03661

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.5.4.4
    Human Readable Name DRUGGABLE GENOME
    Target Subclass 3.5.4.4
    Target Main Class Enzymes
    Interpro Name Adenosine/AMP deaminase domain
    Interpro Short Name A/AMP_deaminase_dom
    Interpro Type Domain
    Interpro Acc IPR001365
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Cabanillas, 2000, Purine nucleoside analogs in indolent non-Hodgkin's lymphoma., Oncology (Williston Park, N.Y.)
    Newman et al., 2007, Natural products as sources of new drugs over the last 25 years., J. Nat. Prod.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jackson et al., 1986, The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase., Adv. Enzyme Regul.
    Kononenko et al., [The effect of hydrocortisone on the activity of 5'-nucleotidase and adenosine deaminase in the hypothalamus and hippocampus of the rat brain]., Probl Endokrinol (Mosk)
    Vodnala SK et al., 2013, Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis., J Med Chem
    Melzig et al., 1995, Inhibition of adenosine deaminase activity of aortic endothelial cells by extracts of garlic (Allium sativum L.)., Pharmazie
    Baggott et al., 1986, Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide., Biochem. J.
    Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.
    Takezako et al., 2001, Adenosine activates aromatic L-amino acid decarboxylase activity in the kidney and increases dopamine., J. Am. Soc. Nephrol.
  • PENTOSTATIN   ADA

    Interaction Score: 22.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name pentostatin,Nipent
    Novel drug target Established target
    Mechanism of Interaction Adenosine deaminase inhibitor

    PMIDs:
    10887639 17309302 11752352 2433905


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ELAPEGADEMASE   ADA

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CORDYCEPIN   ADA

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24283924


    Sources:
    DTC

  • GARLIC   ADA

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7604070


    Sources:
    NCI

  • AMITRIPTYLINE   ADA

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16283318


    Sources:
    NCI

  • CLADRIBINE   ADA

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIPYRIDAMOLE   ADA

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CRx-150, amoxapine plus dipyridamole
    Novel drug target Established target
    Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial TEND

  • LEVODOPA   ADA

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11134247


    Sources:
    NCI

  • HYDROCORTISONE   ADA

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2395837


    Sources:
    NCI

  • FLUDARABINE   ADA

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • METHOTREXATE   ADA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2431676


    Sources:
    NCI

  • Ensembl: ENSG00000196839

    • Version: 101_38

    Alternate Names:
    ADA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P00813

    • Version: 01-August-2011

    Alternate Names:
    P00813 Uniprot Accession
    100 Entrez Gene Id
    ENSG00000196839 Ensembl Gene Id

    Gene Info:
    Target Subclass 3.5.4.4
    Target Main Class Enzymes

    Publications:

  • RussLampel: ENSG00000196839

    • Version: 26-July-2011

    Alternate Names:
    ADA Display Id
    ADENOSINE DEAMINASE (EC 3.5.4.4) (ADENOSINE AMINOHYDROLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00813] Description
    ENSG00000196839 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P00813

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000196839 Ensembl Gene Id
    P00813 Uniprot Accession
    100 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Adenosine/AMP deaminase domain
    Interpro Short Name A/AMP_deaminase_dom

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00813

    • Version: January-2014

    Alternate Names:
    ADA Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.5.4.4

    Publications:

  • NCI: ADA

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Van Heukelom et al., 1976, Characterization of adenosine deaminase isozymes from normal human erythrocytes., Clin. Chim. Acta
    Cooper et al., 1997, The role of divalent cations in structure and function of murine adenosine deaminase., Protein Sci.
    Murray et al., 1988, Induction of adenosine deaminase and 5' nucleotidase activity in cultured human blood monocytes and monocytic leukemia (THP-1) cells by differentiating agents., J. Leukoc. Biol.

  • DTC: ADA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Vodnala SK et al., 2013, Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis., J Med Chem

  • HingoraniCasas: ENSG00000196839

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196839 Gene Symbol
    ADA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADA1

    • Version: chembl_23

    Alternate Names:
    ADA1 GENE_SYMBOL
    ADA GENE_SYMBOL
    Adenosine deaminase UNIPROT

    Gene Info:

    Publications:

  • GO: ADA

    • Version: 01-February-2022

    Alternate Names:
    ADA1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Adenosine deaminase

    • Version: 2020.06.01

    Alternate Names:
    ADA TTD Gene Abbreviation
    T03661 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ADA

    • Version: 01-February-2022

    Alternate Names:
    Adenosine deaminase Gene Name
    P00813 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21