DGIdb - ADCY2 Gene Record

ADCY2 108 Druggable Genome

Alternate Names:

108
ADENYLATE CYCLASE 2
ADCY2
AC2
HBAC2
103071
233
ENSG00000078295
OTTHUMG00000090476
BE0003732
Q08462
ADCY2_HUMAN
ADENYLATE CYCLASE TYPE 2
ADENYLATE CYCLASE, TYPE II (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE 2) (ADENYLYL CYCLASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08462]
adenylyl cyclase 2
PA24561
1279

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	Adenylyl cyclase class-3/4/guanylyl cyclase
Interpro Acc	IPR001054
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Short Name	A/G_cyclase
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Adenylyl cyclases (ACs)
GuideToPharmacology Gene Category ID	257

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

van Huis-Tanja LH et al., 2015, Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients., Pharmacogenet Genomics
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Schlicker C et al., 2008, Structure-based development of novel adenylyl cyclase inhibitors., J Med Chem

CHEMBL401844 ADCY2

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18630896

Sources:
DTC
AUROTHIOGLUCOSE ADCY2

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
COLFORSIN ADCY2

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CAPECITABINE ADCY2

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25815774

Sources:
PharmGKB

Ensembl: ENSG00000078295
- Version: 101_38
Alternate Names:

ADCY2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q08462
- Version: 11-September-2012
Alternate Names:

ADCY2 Uniprot Gene Name

ENSG00000078295 Ensembl Gene Id

ADENYLATE CYCLASE TYPE 2 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase

Interpro Acc IPR001054

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000078295

Version: 26-July-2011

Alternate Names:

ADCY2 Display Id

ADENYLATE CYCLASE, TYPE II (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE 2) (ADENYLYL CYCLASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08462] Description

ENSG00000078295 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 108
- Version: 29-September-2020
Alternate Names:

233 HUGO Gene ID

233 HUGO Gene Symbol

adenylate cyclase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adenylyl cyclases (ACs)

GuideToPharmacology Gene Category ID 257

Gene Categories:

ENZYME

Publications:
PharmGKB: ADCY2
- Version: 18-August-2020
Alternate Names:

PA24561 PharmGKB ID

Gene Info:

Publications:

van Huis-Tanja LH et al., 2015, Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients., Pharmacogenet Genomics
DrugBank: BE0003732
- Version: 5.1.7
Alternate Names:

ADCY2 DrugBank Gene Name

Q08462 UniProt Accession

108 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
DTC: ADCY2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Schlicker C et al., 2008, Structure-based development of novel adenylyl cyclase inhibitors., J Med Chem
Pharos: ADCY2
- Version: 03-September-2020
Alternate Names:

Adenylate cyclase type 2 Gene Name

Q08462 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ADCY2	Uniprot Gene Name
ENSG00000078295	Ensembl Gene Id
ADENYLATE CYCLASE TYPE 2	Uniprot Protein Name

ADCY2	Display Id
ADENYLATE CYCLASE, TYPE II (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE 2) (ADENYLYL CYCLASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08462]	Description
ENSG00000078295	Ensembl Gene Id

233	HUGO Gene ID
233	HUGO Gene Symbol
adenylate cyclase 2	HUGO Gene Name

ADCY2	DrugBank Gene Name
Q08462	UniProt Accession
108	Entrez Gene Id

ADCY2 Gene Record

ADCY2 108 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL401844 ADCY2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18630896

Sources: DTC

AUROTHIOGLUCOSE ADCY2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

COLFORSIN ADCY2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

CAPECITABINE ADCY2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25815774

Sources: PharmGKB

Ensembl: ENSG00000078295

Alternate Names: ADCY2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q08462

Alternate Names: ADCY2 Uniprot Gene Name ENSG00000078295 Ensembl Gene Id ADENYLATE CYCLASE TYPE 2 Uniprot Protein Name

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase Interpro Acc IPR001054

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000078295

Alternate Names: ADCY2 Display Id ADENYLATE CYCLASE, TYPE II (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE 2) (ADENYLYL CYCLASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08462] Description ENSG00000078295 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 108

Alternate Names: 233 HUGO Gene ID 233 HUGO Gene Symbol adenylate cyclase 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Adenylyl cyclases (ACs) GuideToPharmacology Gene Category ID 257

Gene Categories: ENZYME

Publications:

PharmGKB: ADCY2

Alternate Names: PA24561 PharmGKB ID

Gene Info:

Publications: van Huis-Tanja LH et al., 2015, Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients., Pharmacogenet Genomics

DrugBank: BE0003732

Alternate Names: ADCY2 DrugBank Gene Name Q08462 UniProt Accession 108 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DTC: ADCY2

Alternate Names:

Gene Info:

Publications: Schlicker C et al., 2008, Structure-based development of novel adenylyl cyclase inhibitors., J Med Chem

Pharos: ADCY2

Alternate Names: Adenylate cyclase type 2 Gene Name Q08462 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18630896

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
25815774

Sources:
PharmGKB

Alternate Names:

ADCY2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ADCY2 Uniprot Gene Name

ENSG00000078295 Ensembl Gene Id

ADENYLATE CYCLASE TYPE 2 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase

Interpro Acc IPR001054

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ADCY2 Display Id

ADENYLATE CYCLASE, TYPE II (EC 4.6.1.1) (ATP PYROPHOSPHATE-LYASE 2) (ADENYLYL CYCLASE 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08462] Description

ENSG00000078295 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

233 HUGO Gene ID

233 HUGO Gene Symbol

adenylate cyclase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adenylyl cyclases (ACs)

GuideToPharmacology Gene Category ID 257

Gene Categories:

ENZYME

Alternate Names:

PA24561 PharmGKB ID

Publications:

van Huis-Tanja LH et al., 2015, Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients., Pharmacogenet Genomics

Alternate Names:

ADCY2 DrugBank Gene Name

Q08462 UniProt Accession

108 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Publications:

Schlicker C et al., 2008, Structure-based development of novel adenylyl cyclase inhibitors., J Med Chem

Alternate Names:

Adenylate cyclase type 2 Gene Name

Q08462 UniProt ID

Gene Categories:

ENZYME