• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ADD1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ADD1 118

    Alternate Names:

    118
    ADDUCIN 1
    ADD1
    ADDA
    102680
    243
    ENSG00000087274
    OTTHUMG00000122080
    PA31
    Alpha-adducin
    P35611

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    KINASE

    Publications:

    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Cusi D et al., 1997, Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension., Lancet
    Suonsyrjä T et al., 2009, Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study., Am J Hypertens
    Manunta P et al., 2008, Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation., Hypertension
    Turner ST et al., 2003, Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide., Am J Hypertens
    Sciarrone MT et al., 2003, ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy., Hypertension
    Glorioso N et al., 2002, alpha-Adducin 460Trp allele is associated with erythrocyte Na transport rate in North Sardinian primary hypertensives., Hypertension
    Glorioso N et al., 1999, The role of alpha-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study., Hypertension
    Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)
  • FUROSEMIDE   ADD1

    Interaction Score: 3.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21692745 20877298


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ADD1

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9149697 19057513 18591455 14553962 12623934 11882573 10523341


    Sources:
    PharmGKB

  • TORSEMIDE   ADD1

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • BUMETANIDE   ADD1

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298


    Sources:
    PharmGKB

  • SPIRONOLACTONE   ADD1

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21692745


    Sources:
    PharmGKB

  • Ensembl: ENSG00000087274

    • Version: 101_38

    Alternate Names:
    ADD1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: ADD1

    • Version: 18-August-2020

    Alternate Names:
    PA31 PharmGKB ID

    Gene Info:

    Publications:
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)
    Schelleman H et al., 2007, Diuretic-gene interaction and the risk of myocardial infarction and stroke., Pharmacogenomics J

  • Pharos: ADD1

    • Version: 01-February-2022

    Alternate Names:
    Alpha-adducin Gene Name
    P35611 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21