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ADH1A Gene Record

  • Summary
  • Interactions
  • Claims
  • ADH1A 124 Druggable Genome

    Alternate Names:

    124
    ALCOHOL DEHYDROGENASE 1A (CLASS I), ALPHA POLYPEPTIDE
    ADH1A
    ADH1
    103700
    249
    ENSG00000187758
    OTTHUMG00000131026
    Alcohol dehydrogenase 1A
    Alcohol dehydrogenase subunit alpha
    PA24570
    P07327
    ALCOHOL DEHYDROGENASE ALPHA CHAIN (EC 1.1.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P07327]
    ADH1A_HUMAN
    T65570

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Subclass 1.1.1.1
    Target Main Class Enzymes
    Uniprot Status Swiss-Prot
    Interpro Name Alcohol dehydrogenase superfamily, zinc-type
    Interpro Short Name ADH_SF_Zn-type
    Interpro Acc IPR002085
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Target Class Enzymes
    Target Subclass EC:1.1.1.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Calello et al., 2006, New and novel antidotes in pediatrics., Pediatr Emerg Care
    Betten et al., Antidote use in the critically ill poisoned patient., J Intensive Care Med
    Nagata et al., 1996, Adenosine A2-receptor mediates ethanol-induced arteriolar dilation in rat stomach., Am. J. Physiol.
    Brent, 2009, Fomepizole for ethylene glycol and methanol poisoning., N. Engl. J. Med.
    Nussrallah et al., 1989, Characterization of Coturnix quail liver alcohol dehydrogenase enzymes., Biochemistry
    Mukherjee et al., 2006, Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form a biofilm on catheter surfaces through an ethanol-based mechanism., Infect. Immun.
    Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
  • FOMEPIZOLE   ADH1A

    Interaction Score: 38.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Convivia
    Novel drug target Established target
    Mechanism of Interaction Alcohol dehydrogenase class I inhibitor

    PMIDs:
    16871118 16946442 8997246 19458366 2789998 16790752


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ACETALDEHYDE   ADH1A

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31002879


    Sources:
    PharmGKB

  • ABACAVIR   ADH1A

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24625462


    Sources:
    PharmGKB

  • ALCOHOL   ADH1A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000187758

    • Version: 101_38

    Alternate Names:
    ADH1A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P07327

    • Version: January-2014

    Alternate Names:
    ADH1A Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.1.1.1

    Publications:

  • TEND: P07327

    • Version: 01-August-2011

    Alternate Names:
    ADH1A_HUMAN Uniprot Id
    124 Entrez Gene Id
    ADH1A Gene Symbol

    Gene Info:
    Target Subclass 1.1.1.1
    Target Main Class Enzymes

    Publications:

  • RussLampel: ENSG00000187758

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000187758 Ensembl Gene Id
    ADH1A Display Id
    ALCOHOL DEHYDROGENASE ALPHA CHAIN (EC 1.1.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P07327] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P07327

    • Version: 11-September-2012

    Alternate Names:
    ADH1A Uniprot Gene Name
    124 Entrez Gene Id
    ENSG00000187758 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Name Alcohol dehydrogenase superfamily, zinc-type
    Interpro Short Name ADH_SF_Zn-type

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADH1A

    • Version: 18-August-2020

    Alternate Names:
    PA24570 PharmGKB ID

    Gene Info:

    Publications:
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics

  • ChemblInteractions: ADH1

    • Version: chembl_23

    Alternate Names:
    ADH1 GENE_SYMBOL
    ADH1A GENE_SYMBOL
    Alcohol dehydrogenase 1A UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000187758

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000187758 Gene Symbol
    ADH1A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Alcohol dehydrogenase 1A

    • Version: 2020.06.01

    Alternate Names:
    ADH1A TTD Gene Abbreviation
    T65570 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21