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ADH1B Gene Record

  • Summary
  • Interactions
  • Claims
  • ADH1B 125 Druggable Genome

    Alternate Names:

    125
    ALCOHOL DEHYDROGENASE 1B (CLASS I), BETA POLYPEPTIDE
    ADH1B
    ADH2
    HEL-S-117
    103720
    250
    ENSG00000196616
    OTTHUMG00000161413
    P00325
    Alcohol dehydrogenase subunit beta
    Alcohol dehydrogenase 1B
    PA24571
    ADH1B_HUMAN
    ALCOHOL DEHYDROGENASE BETA CHAIN (EC 1.1.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P00325]

    Gene Info:

    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Name Alcohol dehydrogenase superfamily, zinc-type
    Interpro Acc IPR002085
    Interpro Short Name ADH_SF_Zn-type
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Target Class Enzymes
    Target Subclass EC:1.1.1.1
    Target Main Class Enzymes
    Target Subclass 1.1.1.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Kassam et al., In vitro studies of human liver alcohol dehydrogenase variants using a variety of substrates., Drug Metab. Dispos.
    Eriksson et al., 2001, Functional relevance of human adh polymorphism., Alcohol. Clin. Exp. Res.
    Yin et al., 1992, Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity., Biochem. Genet.
    Calello et al., 2006, New and novel antidotes in pediatrics., Pediatr Emerg Care
    Betten et al., Antidote use in the critically ill poisoned patient., J Intensive Care Med
    Brent, 2009, Fomepizole for ethylene glycol and methanol poisoning., N. Engl. J. Med.
    Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
    Seng KY et al., 2013, Population pharmacokinetics and pharmacogenetics of alcohol in Chinese and Indians in Singapore., J Clin Pharm Ther
    Edenberg HJ et al., 2006, Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis., Hum Mol Genet
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
    Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics
  • FOMEPIZOLE   ADH1B

    Interaction Score: 34.78

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Convivia
    Novel drug target Established target
    Mechanism of Interaction Alcohol dehydrogenase class I inhibitor

    PMIDs:
    2573502 11391066 1590750 16871118 16946442 19458366


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ACETALDEHYDE   ADH1B

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31002879


    Sources:
    PharmGKB

  • ABACAVIR   ADH1B

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24625462


    Sources:
    PharmGKB

  • ALCOHOL   ADH1B

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486 23240771 16571603 15902904


    Sources:
    PharmGKB

  • Ensembl: ENSG00000196616

    • Version: 101_38

    Alternate Names:
    ADH1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000196616

    • Version: 26-July-2011

    Alternate Names:
    ALCOHOL DEHYDROGENASE BETA CHAIN (EC 1.1.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P00325] Description
    ENSG00000196616 Ensembl Gene Id
    ADH1B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P00325

    • Version: 01-August-2011

    Alternate Names:
    125 Entrez Gene Id
    P00325 Uniprot Accession
    ADH1B Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 1.1.1.1

    Publications:

  • HopkinsGroom: P00325

    • Version: 11-September-2012

    Alternate Names:
    ADH1B_HUMAN Uniprot Id
    ENSG00000196616 Ensembl Gene Id
    P00325 Uniprot Accession

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Name Alcohol dehydrogenase superfamily, zinc-type

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00325

    • Version: January-2014

    Alternate Names:
    ADH1B Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.1.1.1

    Publications:

  • PharmGKB: ADH1B

    • Version: 18-August-2020

    Alternate Names:
    PA24571 PharmGKB ID

    Gene Info:

    Publications:
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Edenberg HJ et al., 2006, Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis., Hum Mol Genet
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol

  • ChemblInteractions: ADH2

    • Version: chembl_23

    Alternate Names:
    ADH2 GENE_SYMBOL
    ADH1B GENE_SYMBOL
    Alcohol dehydrogenase 1B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000196616

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196616 Gene Symbol
    ADH1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ADH1B

    • Version: 01-February-2022

    Alternate Names:
    Alcohol dehydrogenase 1B Gene Name
    P00325 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21