DGIdb - ADH1C Gene Record

ADH1C 126 Druggable Genome

Alternate Names:

126
ALCOHOL DEHYDROGENASE 1C (CLASS I), GAMMA POLYPEPTIDE
ADH1C
ADH3
103730
251
ENSG00000248144
OTTHUMG00000161422
P00326
ADH1G_HUMAN
ALCOHOL DEHYDROGENASE 1C
PA24572
Alcohol dehydrogenase subunit gamma

Gene Info:

Interpro Acc	IPR002085
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Alcohol dehydrogenase superfamily, zinc-type
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	ADH_SF_Zn-type
Target Class	Enzymes
Target Subclass	EC:1.1.1.1
Target Main Class	Enzymes
Target Subclass	1.1.1.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Calello et al., 2006, New and novel antidotes in pediatrics., Pediatr Emerg Care
Brent, 2009, Fomepizole for ethylene glycol and methanol poisoning., N. Engl. J. Med.
Eriksson et al., 2001, Functional relevance of human adh polymorphism., Alcohol. Clin. Exp. Res.
Betten et al., Antidote use in the critically ill poisoned patient., J Intensive Care Med
Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics
Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
Brennan P et al., 2004, Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review., Am J Epidemiol

FOMEPIZOLE ADH1C

Interaction Score: 21.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Convivia

Mechanism of Interaction Alcohol dehydrogenase class I inhibitor

PMIDs:
16871118 19458366 11391066 16946442

Sources:
TdgClinicalTrial ChemblInteractions TEND
ABACAVIR ADH1C

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24625462

Sources:
PharmGKB
ALCOHOL ADH1C

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32451486 14693654

Sources:
PharmGKB
CYCLOPHOSPHAMIDE ADH1C

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24533712

Sources:
PharmGKB
CISPLATIN ADH1C

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24533712

Sources:
PharmGKB

Ensembl: ENSG00000248144
- Version: 101_38
Alternate Names:

ADH1C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P00326
- Version: 11-September-2012
Alternate Names:

ALCOHOL DEHYDROGENASE 1C Uniprot Protein Name

ADH1C Uniprot Gene Name

ADH1G_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002085

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P00326
- Version: January-2014
Alternate Names:

ADH1C Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.1.1.1

Publications:
TEND: P00326
- Version: 01-August-2011
Alternate Names:

ADH1G_HUMAN Uniprot Id

P00326 Uniprot Accession

ADH1C Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 1.1.1.1

Publications:

PharmGKB: ADH1C

Version: 18-August-2020

Alternate Names:

PA24572 PharmGKB ID

Gene Info:

Publications:

Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics

Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics

Brennan P et al., 2004, Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review., Am J Epidemiol

NCI: ADH1C
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Molotkov et al., 2002, Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3., Proc. Natl. Acad. Sci. U.S.A.
HingoraniCasas: ENSG00000248144
- Version: 31-May-2017
Alternate Names:

ENSG00000248144 Gene Symbol

ADH1C Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADH3
- Version: chembl_23
Alternate Names:

ADH3 GENE_SYMBOL

ADH1C GENE_SYMBOL

Alcohol dehydrogenase 1C UNIPROT

Gene Info:

Publications:
Pharos: ADH1C
- Version: 01-February-2022
Alternate Names:

Alcohol dehydrogenase 1C Gene Name

P00326 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Novel drug target	Established target
Trial Name	Convivia
Mechanism of Interaction	Alcohol dehydrogenase class I inhibitor

ALCOHOL DEHYDROGENASE 1C	Uniprot Protein Name
ADH1C	Uniprot Gene Name
ADH1G_HUMAN	Uniprot Id

ADH3	GENE_SYMBOL
ADH1C	GENE_SYMBOL
Alcohol dehydrogenase 1C	UNIPROT

ADH1C Gene Record

ADH1C 126 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

FOMEPIZOLE ADH1C

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Convivia Mechanism of Interaction Alcohol dehydrogenase class I inhibitor

PMIDs: 16871118 19458366 11391066 16946442

Sources: TdgClinicalTrial ChemblInteractions TEND

ABACAVIR ADH1C

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24625462

Sources: PharmGKB

ALCOHOL ADH1C

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 32451486 14693654

Sources: PharmGKB

CYCLOPHOSPHAMIDE ADH1C

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24533712

Sources: PharmGKB

CISPLATIN ADH1C

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24533712

Sources: PharmGKB

Ensembl: ENSG00000248144

Alternate Names: ADH1C Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P00326

Alternate Names: ALCOHOL DEHYDROGENASE 1C Uniprot Protein Name ADH1C Uniprot Gene Name ADH1G_HUMAN Uniprot Id

Gene Info: Interpro Acc IPR002085 Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P00326

Alternate Names: ADH1C Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.1.1.1

Publications:

TEND: P00326

Alternate Names: ADH1G_HUMAN Uniprot Id P00326 Uniprot Accession ADH1C Gene Symbol

Gene Info: Target Main Class Enzymes Target Subclass 1.1.1.1

Publications:

PharmGKB: ADH1C

Alternate Names: PA24572 PharmGKB ID

Gene Info:

NCI: ADH1C

Alternate Names:

Gene Info:

Publications: Molotkov et al., 2002, Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3., Proc. Natl. Acad. Sci. U.S.A.

HingoraniCasas: ENSG00000248144

Alternate Names: ENSG00000248144 Gene Symbol ADH1C Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ADH3

Alternate Names: ADH3 GENE_SYMBOL ADH1C GENE_SYMBOL Alcohol dehydrogenase 1C UNIPROT

Gene Info:

Publications:

Pharos: ADH1C

Alternate Names: Alcohol dehydrogenase 1C Gene Name P00326 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Convivia

Mechanism of Interaction Alcohol dehydrogenase class I inhibitor

PMIDs:
16871118 19458366 11391066 16946442

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
24625462

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
32451486 14693654

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24533712

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24533712

Sources:
PharmGKB

Alternate Names:

ADH1C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ALCOHOL DEHYDROGENASE 1C Uniprot Protein Name

ADH1C Uniprot Gene Name

ADH1G_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002085

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ADH1C Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.1.1.1

Alternate Names:

ADH1G_HUMAN Uniprot Id

P00326 Uniprot Accession

ADH1C Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 1.1.1.1

Alternate Names:

PA24572 PharmGKB ID

Publications:

Molotkov et al., 2002, Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3., Proc. Natl. Acad. Sci. U.S.A.

Alternate Names:

ENSG00000248144 Gene Symbol

ADH1C Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ADH3 GENE_SYMBOL

ADH1C GENE_SYMBOL

Alcohol dehydrogenase 1C UNIPROT

Alternate Names:

Alcohol dehydrogenase 1C Gene Name

P00326 UniProt ID

Gene Categories:

ENZYME