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ADK Gene Record

  • Summary
  • Interactions
  • Claims
  • ADK 132 Druggable Genome

    Alternate Names:

    132
    ADENOSINE KINASE
    ADK
    AK
    102750
    257
    ENSG00000156110
    OTTHUMG00000018506
    ADENOSINE KINASE (EC 2.7.1.20) (AK) (ADENOSINE 5'-PHOSPHOTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P55263]
    P55263
    ADK_HUMAN
    PA24579
    T91661

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name Carboh/pur_kinase_PfkB_CS
    Human Readable Name KINASE
    Interpro Type Conserved_site
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Carbohydrate/puine kinase, PfkB, conserved site
    Interpro Acc IPR002173
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem
    Singh et al., 1983, Comparison of the mutagenic responses of 12 anticancer drugs at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci in Chinese hamster ovary cells., Environ Mutagen
    Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics
  • LOMUSTINE   ADK

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6317371


    Sources:
    NCI

  • DABIGATRAN   ADK

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22494098


    Sources:
    DTC

  • ABACAVIR   ADK

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24625462


    Sources:
    PharmGKB

  • DACARBAZINE   ADK

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6317371


    Sources:
    NCI

  • BUSULFAN   ADK

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6317371


    Sources:
    NCI

  • BLEOMYCIN   ADK

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6317371


    Sources:
    NCI

  • Ensembl: ENSG00000156110

    • Version: 101_38

    Alternate Names:
    ADK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000156110

    • Version: 26-July-2011

    Alternate Names:
    ADENOSINE KINASE (EC 2.7.1.20) (AK) (ADENOSINE 5'-PHOSPHOTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P55263] Description
    ENSG00000156110 Ensembl Gene Id
    ADK Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P55263

    • Version: 11-September-2012

    Alternate Names:
    ADK Uniprot Gene Name
    P55263 Uniprot Accession
    ADK_HUMAN Uniprot Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Carboh/pur_kinase_PfkB_CS
    Human Readable Name KINASE

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADK

    • Version: 18-August-2020

    Alternate Names:
    PA24579 PharmGKB ID

    Gene Info:

    Publications:
    Barbarino JM et al., 2014, PharmGKB summary: abacavir pathway., Pharmacogenet Genomics

  • NCI: ADK

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Singh et al., 1983, Comparison of the mutagenic responses of 12 anticancer drugs at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci in Chinese hamster ovary cells., Environ Mutagen
    Johnson et al., 1988, Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells., J. Biol. Chem.

  • DTC: ADK

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem

  • HingoraniCasas: ENSG00000156110

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000156110 Gene Symbol
    ADK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Adenosine kinase

    • Version: 2020.06.01

    Alternate Names:
    ADK TTD Gene Abbreviation
    T91661 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ADK

    • Version: 01-February-2022

    Alternate Names:
    Adenosine kinase Gene Name
    P55263 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21