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ADM Gene Record

  • Summary
  • Interactions
  • Claims
  • ADM 133 Druggable Genome

    Alternate Names:

    133
    ADRENOMEDULLIN
    ADM
    AM
    PAMP
    103275
    259
    ENSG00000148926
    OTTHUMG00000165907
    PA24580

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
    Roldós V et al., 2012, Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments., Eur J Med Chem
    Glubb DM et al., 2010, Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine., Pharmacogenomics J
    Shimosawa et al., 2003, Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress., Hypertension
    Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.
  • CHEMBL2063510   ADM

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22884224


    Sources:
    DTC

  • CHEMBL472004   ADM

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22884224


    Sources:
    DTC

  • ALTEPLASE   ADM

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10848972


    Sources:
    NCI

  • PAROXETINE   ADM

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19636336


    Sources:
    PharmGKB

  • INDOMETHACIN   ADM

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10830296


    Sources:
    NCI

  • CHEMBL35482   ADM

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10830296


    Sources:
    NCI

  • INSULIN   ADM

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12668590


    Sources:
    NCI

  • Ensembl: ENSG00000148926

    • Version: 101_38

    Alternate Names:
    ADM Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: ADM

    • Version: 18-August-2020

    Alternate Names:
    PA24580 PharmGKB ID

    Gene Info:

    Publications:
    Glubb DM et al., 2010, Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine., Pharmacogenomics J

  • NCI: ADM

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Shimosawa et al., 2003, Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress., Hypertension
    Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
    Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.

  • DTC: ADM

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Roldós V et al., 2012, Identification of first proadrenomedullin N-terminal 20 peptide (PAMP) modulator by means of virtual screening and NMR interaction experiments., Eur J Med Chem

  • HingoraniCasas: ENSG00000148926

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000148926 Gene Symbol
    ADM Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ADM

    • Version: 01-February-2022

    Alternate Names:
    AM GO Gene Synonym

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21