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ADORA2B Gene Record

  • Summary
  • Interactions
  • Claims
  • ADORA2B 136 Druggable Genome

    Alternate Names:

    136
    ADENOSINE A2B RECEPTOR
    ADORA2B
    ADORA2
    600446
    264
    ENSG00000170425
    OTTHUMG00000059140
    ADENOSINE RECEPTOR A2B
    P29275
    AA2BR_HUMAN
    BE0000241
    ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275]
    20
    A<sub>2B</sub> receptor
    NP_000667
    NM_000676
    P29274
    ADORA2A
    T86679

    Gene Info:

    Target Subclass Rhodopsin
    Target Subclass GPCR
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Interpro Acc IPR000276
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Target Class Receptors
    GuideToPharmacology Gene Category Name Adenosine receptors
    GuideToPharmacology Gene Category ID 3
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Fozard et al., 2003, Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog., Eur. J. Pharmacol.
    Philipp et al., 2006, Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade., Cardiovasc. Res.
    Holgate, 2005, The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
    Phelps et al., 2006, Characterization of adenosine receptors in the human bladder carcinoma T24 cell line., Eur. J. Pharmacol.
    Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
    Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
    Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
    Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
    Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
    Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
    Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
    Ribeiro et al., 2010, Caffeine and adenosine., J. Alzheimers Dis.
    Bianchi et al., 1993, Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptor agonist., Eur. J. Pharmacol.
  • LAS101057   ADORA2B

    Interaction Score: 2.91

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2b receptor antagonist

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • XANTHINE   ADORA2B

    Interaction Score: 1.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL482436   ADORA2B

    Interaction Score: 1.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ADENOSINE   ADORA2B

    Interaction Score: 1.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor agonist
    Direct Interaction yes
    Specific Action of the Ligand Agonist

    PMIDs:
    17442976 20370661 20370662 20136829 17321471 16339914 17438146


    Sources:
    TTD DrugBank GuideToPharmacology ChemblInteractions

  • BVT.115959   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BVT.115959
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TOZADENANT   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SYN-115
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • QAF805   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine A2b receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AB-928   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ENPROFYLLINE   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15980878 11752352


    Sources:
    DrugBank

  • ALLOXAZINE   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BINODENOSON   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • VIDARABINE   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TONAPOFYLLINE   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • PRELADENANT   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name preladenant, SCH-420814

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • ISTRADEFYLLINE   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name istradefylline, KW-6002
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • GS 6201   ADORA2B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2b receptor antagonist
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • DEFIBROTIDE   ADORA2B

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8405101


    Sources:
    DrugBank

  • REGADENOSON   ADORA2B

    Interaction Score: 0.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Trial Name regadenoson,Lexiscan

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • THEOPHYLLINE   ADORA2B

    Interaction Score: 0.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ADC4022, low-dose inhaled theophylline
    Novel drug target Established target
    Mechanism of Interaction Adenosine receptor antagonist

    PMIDs:
    12954362 16545350 15980878 11752352 3588607 16581066


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL27508   ADORA2B

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAFFEINE, CITRATED   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DERENOFYLLINE   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PICLIDENOSON   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ROLOFYLLINE   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ST1535   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FK453   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VIPADENANT   ADORA2B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ZM-241385   ADORA2B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AMMONIUM TRICHLOROTELLURATE   ADORA2B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NAMODENOSON   ADORA2B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • N6-CYCLOPENTYLADENOSINE   ADORA2B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CAFFEINE   ADORA2B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Antagonist

    PMIDs:
    20164566


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • NECA   ADORA2B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THEOPHYLLINE SODIUM GLYCINATE   ADORA2B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL285819   ADORA2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL375293   ADORA2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AMINOPHYLLINE   ADORA2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXTRIPHYLLINE   ADORA2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adenosine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOXIFYLLINE   ADORA2B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adenosine A2 receptor antagonist
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology ChemblInteractions

  • Ensembl: ENSG00000170425

    • Version: 101_38

    Alternate Names:
    ADORA2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P29275

    • Version: 01-August-2011

    Alternate Names:
    ADORA2B Gene Symbol
    AA2BR_HUMAN Uniprot Id
    P29275 Uniprot Accession

    Gene Info:
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000170425

    • Version: 26-July-2011

    Alternate Names:
    ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275] Description
    ENSG00000170425 Ensembl Gene Id
    ADORA2B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P29275

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000170425 Ensembl Gene Id
    ADENOSINE RECEPTOR A2B Uniprot Protein Name
    136 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P29275

    • Version: January-2014

    Alternate Names:
    ADORA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TdgClinicalTrial: P29274

    • Version: January-2014

    Alternate Names:
    ADORA2A Gene Symbol
    ADORA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • GuideToPharmacology: 136

    • Version: 29-September-2020

    Alternate Names:
    264 HUGO Gene ID
    264 HUGO Gene Symbol
    adenosine A2b receptor HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Adenosine receptors
    GuideToPharmacology Gene Category ID 3

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000241

    • Version: 5.1.7

    Alternate Names:
    ADORA2B DrugBank Gene Name
    P29275 UniProt Accession
    136 Entrez Gene Id

    Gene Info:

    Publications:
    Fozard et al., 2003, Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog., Eur. J. Pharmacol.
    Philipp et al., 2006, Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade., Cardiovasc. Res.
    Holgate, 2005, The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma., Br. J. Pharmacol.

  • HingoraniCasas: ENSG00000170425

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170425 Gene Symbol
    ADORA2B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADORA2B

    • Version: chembl_23

    Alternate Names:
    ADORA2B GENE_SYMBOL
    Adenosine receptor A2b UNIPROT

    Gene Info:

    Publications:

  • dGene: ADORA2B

    • Version: 27-Jun-2013

    Alternate Names:
    136 Gene ID
    ADORA2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adenosine A2b receptor

    • Version: 2020.06.01

    Alternate Names:
    ADORA2B TTD Gene Abbreviation
    T86679 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21