148 |
ADRENOCEPTOR ALPHA 1A |
ADRA1A |
ADRA1C |
ADRA1L1 |
ALPHA1AAR |
104221 |
277 |
ENSG00000120907 |
OTTHUMG00000099459 |
P35348 |
ADA1A_HUMAN |
Alpha-adrenergic receptor 1a |
Alpha-1D adrenoceptor |
Alpha-1D adrenoreceptor |
Alpha-1D adrenergic receptor |
Alpha-1A adrenergic receptor |
ADRA1D |
Alpha-1A adrenoceptor |
Alpha-1A adrenoreceptor |
Alpha-1C adrenergic receptor |
Alpha-adrenergic receptor 1c |
ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348] |
PA34 |
Adrenergic receptor alpha-1A |
T92609 |
Interpro Acc | IPR000276 |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Target Main Class | Receptors |
Transmembrane Helix Count | 7 |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Mechanism of Interaction | Alpha-1a adrenergic receptor antagonist |
Direct Interaction | yes |
Novel drug target | Established target |
agonist (activating) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Trial Name | dutasteride + tamsulosin,Jalyn |
Novel drug target | Established target |
Trial Name | tamsulosin, YM-617,Harnal, Flomax |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Alpha-1a adrenergic receptor antagonist |
Direct Interaction | yes |
partial agonist (activating) |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Alpha-1a adrenergic receptor partial agonist |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Alpha-1a adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Alpha-1a adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | aviptadil,Invicorp |
Novel drug target | Established target |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
inhibitor (inhibitory) |
potentiator |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
Direct Interaction | yes |
Trial Name | carvedilol, Coreg |
n/a |
Novel drug target | Established target |
Trial Name | Serdolect |
agonist (activating) |
Trial Name | PSD-503, phenylephrine |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha-1 agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
Trial Name | transdermal lidocaine/epinephrine patch,Lidosite |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
Direct Interaction | yes |
n/a |
Trial Name | AGN-214868 |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha agonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Alpha-1a adrenergic receptor antagonist |
Trial Name | Lu AA24530 |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor alpha agonist |
Direct Interaction | yes |
n/a |
Trial Name | pardoprunox, SLV 308 |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
antagonist (inhibitory) |
Trial Name | iloperidone,Fanapt, Fiapta, Zomaril |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor alpha-1 antagonist |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor agonist |
antagonist (inhibitory) |
Trial Name | Asenapine |
Novel drug target | Established target |
n/a |
Trial Name | amiodarone HCl,Amio-Aqueous IV |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Adrenergic receptor alpha antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Adrenergic receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Adrenergic receptor agonist |
antagonist (inhibitory) |
Trial Name | ALKS 3831 |
Trial Name | OREX-003, olanzapine plus zonisamide SR |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
ADRA1A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ALPHA-1A ADRENERGIC RECEPTOR (ALPHA 1A-ADRENOCEPTOR) (ALPHA 1A- ADRENORECEPTOR) (ALPHA-1C ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1C). [SOURCE:UNIPROT/SWISSPROT;ACC:P35348] | Description |
ADRA1A | Display Id |
ENSG00000120907 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ADRA1A | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
ADRA1A | Uniprot Gene Name |
148 | Entrez Gene Id |
ENSG00000120907 | Ensembl Gene Id |
Interpro Acc | IPR000276 |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
ADRA1A | Gene Symbol |
ADA1A_HUMAN | Uniprot Id |
P35348 | Uniprot Accession |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Target Main Class | Receptors |
PA34 | PharmGKB ID |
ENSG00000120907 | Gene Symbol |
ADRA1A | Ensembl Id |
DRUGGABLE GENOME |
ADRA1C | GENE_SYMBOL |
ADRA1A | GENE_SYMBOL |
Alpha-1A adrenergic receptor | UNIPROT |
ADRA1A | GENE_SYMBOL |
ADRA1D | GENE_SYMBOL |
Alpha-1D adrenergic receptor | UNIPROT |
ADRA1C | GO Gene Synonym |
G PROTEIN COUPLED RECEPTOR |
148 | Gene ID |
ADRA1C | dGene Synonym |
ADRA1L1 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
ADRA1A | TTD Gene Abbreviation |
T92609 | TTD Target ID |