DGIdb - ADRA1B Gene Record

ADRA1B 147 Druggable Genome

Alternate Names:

147
ADRENOCEPTOR ALPHA 1B
ADRA1B
ADRA1
ALPHA1BAR
104220
278
ENSG00000170214
OTTHUMG00000130327
P35368
Alpha-1B adrenoreceptor
Alpha-1B adrenergic receptor
Alpha-1B adrenoceptor
ADA1B_HUMAN
ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) (ALPHA 1B- ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P35368]
PA33
Adrenergic receptor alpha-1B
T29500

Gene Info:

Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Richardson et al., 1997, Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes., Prostate
Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Michel et al., 1994, Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle., Br. J. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Allinson RW et al., 1990, Reversal of mydriasis by dapiprazole., Ann Ophthalmol
Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.
Shieh et al., 2009, Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats., Acta Pharmacol. Sin.
Testa et al., 1995, Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype., Br. J. Pharmacol.
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Izzo et al., 1994, Regulation of alpha 1B-adrenergic receptor half-life: protein synthesis dependence and effect of norepinephrine., Am. J. Physiol.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Eltze, 1996, In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors., Eur. J. Pharmacol.
Sleight et al., 1993, Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors., Eur. J. Pharmacol.
Sharpe et al., 2003, Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA., J. Biol. Chem.
Al-Damluji et al., 2001, alpha(1B) adrenergic receptors in gonadotrophin-releasing hormone neurones: relation to Transport-P., Br. J. Pharmacol.
Simpson, 1985, Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating., Circ. Res.
Oleksa et al., 1996, Alpha 1-adrenergic inhibition of the beta-adrenergically activated Cl- current in guinea pig ventricular myocytes., Circ. Res.
Waugh et al., 2001, Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like antagonists., J. Biol. Chem.
Tsujimoto et al., 1989, Glycogen phosphorylase activation by two different alpha 1-adrenergic receptor subtypes: methoxamine selectively stimulates a putative alpha 1-adrenergic receptor subtype (alpha 1a) that couples with Ca2+ influx., Mol. Pharmacol.
Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Lepor, 2007, Alpha blockers for the treatment of benign prostatic hyperplasia., Rev Urol
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Bèïque et al., 1998, Are the new selective alpha-blockers better than non-selective alpha-blockers for benign prostatic hyperplasia?, Can Fam Physician
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Uchida et al., 2007, Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine., Life Sci.
Altenbach et al., 2004, Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist., J. Med. Chem.
Izzo et al., 1994, Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells., J. Biol. Chem.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Koshimizu et al., 2004, Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors., Cardiovasc. Res.
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Vincent et al., 1992, Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans., J. Clin. Invest.
Boyle et al., 2001, Meta-analysis of randomized trials of terazosin in the treatment of benign prostatic hyperplasia., Urology
Bray, 2000, A concise review on the therapeutics of obesity., Nutrition
Rothman et al., 2006, Therapeutic potential of monoamine transporter substrates., Curr Top Med Chem
Bray, 2005, Drug Insight: appetite suppressants., Nat Clin Pract Gastroenterol Hepatol
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.

PHENDIMETRAZINE ADRA1B

Interaction Score: 4.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11054601 17017961 11752352 17016423 17139284 16265126

Sources:
TdgClinicalTrial TEND TTD
METHOXAMINE ADRA1B

Interaction Score: 3.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 8635240 11331292 2546049 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
ALFUZOSIN ADRA1B

Interaction Score: 1.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND
DOXAZOSIN ADRA1B

Interaction Score: 1.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19002123 10393471 18231614 17070143 18304211 9223558

Sources:
TdgClinicalTrial TEND
PERICIAZINE ADRA1B

Interaction Score: 1.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
DAPIPRAZOLE ADRA1B

Interaction Score: 1.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 1972008 9401944

Sources:
TdgClinicalTrial TEND
TAMSULOSIN ADRA1B

Interaction Score: 1.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
9294627 12270758 14680444 8996174 11752352 7911719

Sources:
TdgClinicalTrial TEND
LISDEXAMFETAMINE ADRA1B

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 11752352

Sources:
TdgClinicalTrial TEND
PRAZOSIN ADRA1B

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources:
TdgClinicalTrial TEND
DROXIDOPA ADRA1B

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
7773533 20412040 17266602 8166240

Sources:
ChemblInteractions
TERAZOSIN ADRA1B

Interaction Score: 0.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 1358918 11711348 11752352

Sources:
TdgClinicalTrial TEND
METHOXAMINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions
METARAMINOL BITARTRATE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIDODRINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLEPHRINE BITARTRATE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions
NEFAZODONE ADRA1B

Interaction Score: 0.52

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND
NOREPINEPHRINE ADRA1B

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
MIDODRINE ADRA1B

Interaction Score: 0.44

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15163201

Sources:
TdgClinicalTrial TEND
ALFUZOSIN HYDROCHLORIDE ADRA1B

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TAMSULOSIN HYDROCHLORIDE ADRA1B

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYLEPHRINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TERAZOSIN HYDROCHLORIDE HYDRATE ADRA1B

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEBRISOQUIN ADRA1B

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PROPIOMAZINE ADRA1B

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE ADRA1B

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND PharmGKB
LEVOMEPROMAZINE ADRA1B

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
SERTINDOLE ADRA1B

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND
LISDEXAMFETAMINE DIMESYLATE ADRA1B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Vyvanse

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BETHANIDINE ADRA1B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PROMAZINE ADRA1B

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
EPINEPHRINE ADRA1B

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
20857090 20412040 20954794 19730427

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB
CARVEDILOL PHOSPHATE ADRA1B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
RAUWOLFIA SERPENTINA ADRA1B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOXAZOSIN MESYLATE ADRA1B

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAPHAZOLINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRAHYDROZOLINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
SENREBOTASE ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ALSEROXYLON ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEDETOMIDINE ADRA1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OXYMETAZOLINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRIMIPRAMINE MALEATE ADRA1B

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DIPIVEFRIN HYDROCHLORIDE ADRA1B

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENTERMINE SULFATE ADRA1B

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLAZOLINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA1B

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRAZOSIN HYDROCHLORIDE ADRA1B

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUETIAPINE ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 17848919

Sources:
TEND
PHENOXYBENZAMINE HYDROCHLORIDE ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LABETALOL HYDROCHLORIDE ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARVEDILOL ADRA1B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
15306222

Sources:
ChemblInteractions
OLANZAPINE ADRA1B

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
10227113 17848919 17316700 11752352

Sources:
TdgClinicalTrial TEND
ERGOLOID MESYLATES ADRA1B

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NOREPINEPHRINE BITARTRATE ADRA1B

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRAZODONE ADRA1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
METHAMPHETAMINE ADRA1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND TTD
EPINEPHRINE BITARTRATE ADRA1B

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOPAMINE ADRA1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISOPROTERENOL ADRA1B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000170214
- Version: 101_38
Alternate Names:

ADRA1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000170214
- Version: 26-July-2011
Alternate Names:

ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) (ALPHA 1B- ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P35368] Description

ADRA1B Display Id

ENSG00000170214 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P35368
- Version: 11-September-2012
Alternate Names:

147 Entrez Gene Id

P35368 Uniprot Accession

ADRA1B Uniprot Gene Name

Gene Info:

Interpro Type Family

Uniprot Evidence 1: Evidence at protein level

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TEND: P35368
- Version: 01-August-2011
Alternate Names:

P35368 Uniprot Accession

ENSG00000170214 Ensembl Gene Id

ADRA1B Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Publications:
TdgClinicalTrial: P35368
- Version: January-2014
Alternate Names:

ADRA1B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HingoraniCasas: ENSG00000170214
- Version: 31-May-2017
Alternate Names:

ENSG00000170214 Gene Symbol

ADRA1B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA1B
- Version: chembl_23
Alternate Names:

ADRA1B GENE_SYMBOL

Alpha-1B adrenergic receptor UNIPROT

Alpha-1B adrenoreceptor UNIPROT

Gene Info:

Publications:
PharmGKB: ADRA1B
- Version: 18-August-2020
Alternate Names:

PA33 PharmGKB ID

Gene Info:

Publications:
dGene: ADRA1B
- Version: 27-Jun-2013
Alternate Names:

147 Gene ID

ADRA1 dGene Synonym

ALPHA1BAR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-1B
- Version: 2020.06.01
Alternate Names:

ADRA1B TTD Gene Abbreviation

T29500 TTD Target ID

Gene Info:

Publications:
GO: ADRA1B
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Novel drug target	Established target
Trial Name	alfuzosin,UroXatral

Trial Name	tamsulosin, YM-617,Harnal, Flomax
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor agonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor alpha-1 agonist

Mechanism of Interaction	Adrenergic receptor alpha-1 antagonist
Direct Interaction	yes

Trial Name	PSD-503, phenylephrine
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor alpha antagonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ALPHA-1B ADRENERGIC RECEPTOR (ALPHA 1B-ADRENOCEPTOR) (ALPHA 1B- ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P35368]	Description
ADRA1B	Display Id
ENSG00000170214	Ensembl Gene Id

147	Entrez Gene Id
P35368	Uniprot Accession
ADRA1B	Uniprot Gene Name

ADRA1B	GENE_SYMBOL
Alpha-1B adrenergic receptor	UNIPROT
Alpha-1B adrenoreceptor	UNIPROT

ADRA1B Gene Record

ADRA1B 147 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11054601 17017961 11752352 17016423 17139284 16265126

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2988814 8635240 11331292 2546049 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name alfuzosin,UroXatral

PMIDs: 9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 19002123 10393471 18231614 17070143 18304211 9223558

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 1972008 9401944

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tamsulosin, YM-617,Harnal, Flomax Novel drug target Established target

PMIDs: 9294627 12270758 14680444 8996174 11752352 7911719

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor agonist Direct Interaction yes

PMIDs: 7773533 20412040 17266602 8166240

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2988814 1358918 11711348 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-1 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-1 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15163201

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-1 agonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11054601 17017961 11752352 17016423 17139284 16265126

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 8635240 11331292 2546049 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

PMIDs:
9870119 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19002123 10393471 18231614 17070143 18304211 9223558

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 1972008 9401944

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

PMIDs:
9294627 12270758 14680444 8996174 11752352 7911719

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7855217 8925876 12270758 11752352 7691623 12824165 11156594

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
7773533 20412040 17266602 8166240

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2988814 1358918 11711348 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7773533 8294418 8166240 18064417 17266602 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15163201

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions