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ADRA1D Gene Record

  • Summary
  • Interactions
  • Claims
  • ADRA1D 146 Druggable Genome

    Alternate Names:

    146
    ADRENOCEPTOR ALPHA 1D
    ADRA1D
    ADRA1
    ADRA1A
    ADRA1R
    ALPHA1
    DAR
    dJ779E11.2
    104219
    280
    ENSG00000171873
    OTTHUMG00000031779
    P25100
    ALPHA-1D ADRENERGIC RECEPTOR
    ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100]
    ADA1D_HUMAN
    PA24597
    Adrenergic receptor alpha-1D
    T53381

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Acc IPR000276
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
    Allinson RW et al., 1990, Reversal of mydriasis by dapiprazole., Ann Ophthalmol
    Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
    Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
    Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
    Lepor, 2007, Alpha blockers for the treatment of benign prostatic hyperplasia., Rev Urol
    Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
    Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
    Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
    Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
    Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
    Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
    McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
    Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
    Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
    Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
    Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
    Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
    Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.
    Shieh et al., 2009, Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats., Acta Pharmacol. Sin.
    Cleary et al., 2004, Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens., Br. J. Pharmacol.
    Kenny et al., 1995, Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline., Br. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
    Testa et al., 1995, The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta., Life Sci.
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
    Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.
    Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
    Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
    Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
    Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
    Noble et al., 1997, The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes., Br. J. Pharmacol.
    Lowe, 2005, Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia., Rev Urol
    Tomiyama et al., 2006, [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]., Yakugaku Zasshi
    Zeng et al., 2009, Frontal analysis of cell-membrane chromatography for determination of drug-alpha(1D) adrenergic receptor affinity., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
    Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat
  • ALFUZOSIN   ADRA1D

    Interaction Score: 4.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name alfuzosin,UroXatral

    PMIDs:
    16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685


    Sources:
    TdgClinicalTrial TEND TTD

  • DOXAZOSIN   ADRA1D

    Interaction Score: 4.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19002123 10393471 18231614 17070143 9223558 18304211


    Sources:
    TdgClinicalTrial TEND TTD

  • TAMSULOSIN   ADRA1D

    Interaction Score: 3.57

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name tamsulosin, YM-617,Harnal, Flomax
    Novel drug target Established target

    PMIDs:
    14680444 12270758 8996174 9117115 11752352 16986050 16518087


    Sources:
    TdgClinicalTrial TEND

  • DAPIPRAZOLE   ADRA1D

    Interaction Score: 3.57

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 1972008 9401944


    Sources:
    TdgClinicalTrial TEND

  • BUNAZOSIN   ADRA1D

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TRIMAZOSIN   ADRA1D

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ARMODAFINIL   ADRA1D

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19300566


    Sources:
    TTD

  • METHOXAMINE   ADRA1D

    Interaction Score: 1.59

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:

    PMIDs:
    19493707


    Sources:
    PharmGKB

  • PRAZOSIN   ADRA1D

    Interaction Score: 1.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18187928 7855217 11682453


    Sources:
    TdgClinicalTrial TEND

  • PERICIAZINE   ADRA1D

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • MOXISYLYTE   ADRA1D

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NOREPINEPHRINE   ADRA1D

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15451776 7582530 18064417 17266602 7674815 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • TERAZOSIN   ADRA1D

    Interaction Score: 0.95

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • DEBRISOQUIN   ADRA1D

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • LEVOMEPROMAZINE   ADRA1D

    Interaction Score: 0.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15701205 2870716


    Sources:
    TdgClinicalTrial TEND

  • PROPIOMAZINE   ADRA1D

    Interaction Score: 0.68

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • SERTINDOLE   ADRA1D

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Serdolect
    Novel drug target Established target

    PMIDs:
    16925508


    Sources:
    TdgClinicalTrial TEND

  • BETHANIDINE   ADRA1D

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • PROMAZINE   ADRA1D

    Interaction Score: 0.56

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • EPINEPHRINE   ADRA1D

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target

    PMIDs:
    20857090 20412040 20954794 19730427


    Sources:
    TdgClinicalTrial PharmGKB

  • SENREBOTASE   ADRA1D

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AGN-214868
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MEDETOMIDINE   ADRA1D

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENYLEPHRINE   ADRA1D

    Interaction Score: 0.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name PSD-503, phenylephrine
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial PharmGKB

  • PAPAVERINE   ADRA1D

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9351495


    Sources:
    NCI

  • DOPAMINE   ADRA1D

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ISOPROTERENOL   ADRA1D

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000171873

    • Version: 101_38

    Alternate Names:
    ADRA1D Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P25100

    • Version: 01-August-2011

    Alternate Names:
    ADA1D_HUMAN Uniprot Id
    ADRA1D Gene Symbol
    146 Entrez Gene Id

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors

    Publications:

  • TdgClinicalTrial: P25100

    • Version: January-2014

    Alternate Names:
    ADRA1D Gene Symbol

    Gene Info:
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Class Receptors

    Publications:

  • RussLampel: ENSG00000171873

    • Version: 26-July-2011

    Alternate Names:
    ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100] Description
    ADRA1D Display Id
    ENSG00000171873 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P25100

    • Version: 11-September-2012

    Alternate Names:
    ALPHA-1D ADRENERGIC RECEPTOR Uniprot Protein Name
    ADA1D_HUMAN Uniprot Id
    P25100 Uniprot Accession

    Gene Info:
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TTD: Adrenergic receptor alpha-1D

    • Version: 2020.06.01

    Alternate Names:
    ADRA1D TTD Gene Abbreviation
    T53381 TTD Target ID

    Gene Info:

    Publications:
    Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat

  • NCI: ADRA1D

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.
    Campos et al., 2003, Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens., Braz. J. Med. Biol. Res.
    Nikolaidis et al., 2006, The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy., J. Am. Coll. Cardiol.

  • HingoraniCasas: ENSG00000171873

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000171873 Gene Symbol
    ADRA1D Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADRA1D

    • Version: 18-August-2020

    Alternate Names:
    PA24597 PharmGKB ID

    Gene Info:

    Publications:

  • GO: ADRA1D

    • Version: 01-February-2022

    Alternate Names:
    ADRA1A GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: ADRA1D

    • Version: 27-Jun-2013

    Alternate Names:
    146 Gene ID
    ADRA1 dGene Synonym
    ADRA1A dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21