DGIdb - ADRA1D Gene Record

ADRA1D 146 Druggable Genome

Alternate Names:

146
ADRENOCEPTOR ALPHA 1D
ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
104219
280
ENSG00000171873
OTTHUMG00000031779
P25100
ALPHA-1D ADRENERGIC RECEPTOR
BE0000715
24
α<sub>1D</sub>-adrenoceptor
NP_000669
NM_000678
ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100]
ADA1D_HUMAN
PA24597
Adrenergic receptor alpha-1D
T53381

Gene Info:

GuideToPharmacology Gene Category Name	Adrenoceptors
GuideToPharmacology Gene Category ID	4
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Interpro Name	GPCR, rhodopsin-like, 7TM
Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Akinaga et al., 2013, Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline., Mol. Pharmacol.
Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
Gaulton et al., 2012, ChEMBL: a large-scale bioactivity database for drug discovery., Nucleic Acids Res.
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology
Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Zhang D et al., 2004, Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane., Sci China C Life Sci
Koshimizu et al., 2004, Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors., Cardiovasc. Res.
Allinson RW et al., 1990, Reversal of mydriasis by dapiprazole., Ann Ophthalmol
Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Lepor, 2007, Alpha blockers for the treatment of benign prostatic hyperplasia., Rev Urol
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.
Shieh et al., 2009, Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats., Acta Pharmacol. Sin.
Cleary et al., 2004, Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens., Br. J. Pharmacol.
Kenny et al., 1995, Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline., Br. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Testa et al., 1995, The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta., Life Sci.
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.
Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Noble et al., 1997, The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes., Br. J. Pharmacol.
Lowe, 2005, Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia., Rev Urol
Tomiyama et al., 2006, [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]., Yakugaku Zasshi
Zeng et al., 2009, Frontal analysis of cell-membrane chromatography for determination of drug-alpha(1D) adrenergic receptor affinity., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ruffolo et al., 1982, Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist., J. Pharmacol. Exp. Ther.
Horie et al., 1995, Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes., Br. J. Pharmacol.
Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat
Thayer et al., 1985, Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors., Biochem. Pharmacol.
Van Tassell et al., 2008, Carvedilol increases blood pressure response to phenylephrine infusion in heart failure subjects with systolic dysfunction: evidence of improved vascular alpha1-adrenoreceptor signal transduction., Am. Heart J.
Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
Görnemann et al., 2008, Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes., Naunyn Schmiedebergs Arch. Pharmacol.
Minneman et al., 1994, Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes., Mol. Pharmacol.
Altenbach et al., 2002, N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine., J. Med. Chem.
Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
Shibata K et al., 1998, Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors., Circulation

DAPIPRAZOLE ADRA1D

Interaction Score: 1.6

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
17016423 17139284 1972008 9401944

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology
ALFUZOSIN ADRA1D

Interaction Score: 1.49

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

Specific Action of the Ligand Antagonist

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD
TAMSULOSIN ADRA1D

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology
DOXAZOSIN ADRA1D

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD
METHOXAMINE ADRA1D

Interaction Score: 1.07

Interaction Types & Directionality:

binder

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
19493707

Sources:
DrugBank GuideToPharmacology PharmGKB
BUNAZOSIN ADRA1D

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRIMAZOSIN ADRA1D

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ARMODAFINIL ADRA1D

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19300566

Sources:
TTD
SILODOSIN ADRA1D

Interaction Score: 0.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology
PRAZOSIN ADRA1D

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology
CIRAZOLINE ADRA1D

Interaction Score: 0.4

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
6123592 8564227

Sources:
DrugBank
DROXIDOPA ADRA1D

Interaction Score: 0.4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20412040 17266602 7674815 7582530

Sources:
DrugBank
TERAZOSIN ADRA1D

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD
OXYMETAZOLINE ADRA1D

Interaction Score: 0.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
23364786 20030735 21948594

Sources:
DrugBank GuideToPharmacology
NOREPINEPHRINE ADRA1D

Interaction Score: 0.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND PharmGKB
UPIDOSIN ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-123189 ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERICIAZINE ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
A-119637 ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NS-49 ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MOXISYLYTE ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INDORAMIN ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
PHENTOLAMINE ADRA1D

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
15493479 15306222

Sources:
DrugBank GuideToPharmacology
XYLOMETAZOLINE ADRA1D

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20030735

Sources:
DrugBank
PROPIOMAZINE ADRA1D

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
DEBRISOQUIN ADRA1D

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
MIDODRINE ADRA1D

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
12238918

Sources:
DrugBank
CHEMBL56331 ADRA1D

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
LEVOMEPROMAZINE ADRA1D

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15701205 2870716

Sources:
DrugBank TdgClinicalTrial TEND
EPINEPHRINE ADRA1D

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

PMIDs:
20857090 20412040 20954794 19730427

Sources:
DrugBank TdgClinicalTrial PharmGKB
PROMAZINE ADRA1D

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
BETHANIDINE ADRA1D

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE ADRA1D

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
None found

Sources:
DrugBank TdgClinicalTrial PharmGKB
SERTINDOLE ADRA1D

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
DrugBank TdgClinicalTrial TEND
BMY-7378 ADRA1D

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SENREBOTASE ADRA1D

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MEDETOMIDINE ADRA1D

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FENOLDOPAM ADRA1D

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7670737

Sources:
DrugBank
DOXEPIN ADRA1D

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7855217 6086881 19179941

Sources:
DrugBank
CLONIDINE ADRA1D

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11082457

Sources:
DrugBank
PHENOXYBENZAMINE ADRA1D

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7969082

Sources:
DrugBank
PIZOTYLINE ADRA1D

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2045831

Sources:
DrugBank
PAPAVERINE ADRA1D

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9351495

Sources:
NCI
ERGOTAMINE ADRA1D

Interaction Score: 0.09

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
18066532

Sources:
DrugBank
CHEMBL88272 ADRA1D

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERGOLIDE ADRA1D

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10641988

Sources:
DrugBank
DRONEDARONE ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17389667 23997577

Sources:
DrugBank
SPIROXATRINE ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CABERGOLINE ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
12388666

Sources:
DrugBank
CARVEDILOL ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15306222 18657662

Sources:
DrugBank
CHEMBL609728 ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
QUINIDINE ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9570190

Sources:
DrugBank
RACEPINEPHRINE ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
LEVONORDEFRIN ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
NORTRIPTYLINE ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20363235

Sources:
DrugBank
LABETALOL ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
CYPROHEPTADINE ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NICARDIPINE ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2981533

Sources:
DrugBank
OCAPERIDONE ADRA1D

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
BROMOCRIPTINE ADRA1D

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10641988

Sources:
DrugBank
IMIPRAMINE ADRA1D

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20363235

Sources:
DrugBank
SPIPERONE ADRA1D

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
KETANSERIN ADRA1D

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
AMITRIPTYLINE ADRA1D

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20363235

Sources:
DrugBank
RITANSERIN ADRA1D

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
VERAPAMIL ADRA1D

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9570190

Sources:
DrugBank
MIANSERIN ADRA1D

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DOPAMINE ADRA1D

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISOPROTERENOL ADRA1D

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RISPERIDONE ADRA1D

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOZAPINE ADRA1D

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000171873
- Version: 101_38
Alternate Names:

ADRA1D Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P25100
- Version: 01-August-2011
Alternate Names:

ADA1D_HUMAN Uniprot Id

ADRA1D Gene Symbol

146 Entrez Gene Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Publications:
TdgClinicalTrial: P25100
- Version: January-2014
Alternate Names:

ADRA1D Gene Symbol

Gene Info:

Target Subclass GPCR

Target Subclass Rhodopsin

Target Class Receptors

Publications:

RussLampel: ENSG00000171873

Version: 26-July-2011

Alternate Names:

ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100] Description

ADRA1D Display Id

ENSG00000171873 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P25100
- Version: 11-September-2012
Alternate Names:

ALPHA-1D ADRENERGIC RECEPTOR Uniprot Protein Name

ADA1D_HUMAN Uniprot Id

P25100 Uniprot Accession

Gene Info:

Interpro Type Family

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 146
- Version: 29-September-2020
Alternate Names:

280 HUGO Gene ID

280 HUGO Gene Symbol

adrenoceptor alpha 1D HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adrenoceptors

GuideToPharmacology Gene Category ID 4

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

DrugBank: BE0000715

Version: 5.1.7

Alternate Names:

ADRA1D DrugBank Gene Name

P25100 UniProt Accession

146 Entrez Gene Id

Gene Info:

Publications:

Altenbach et al., 2002, N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine., J. Med. Chem.

Millan et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes., J. Pharmacol. Exp. Ther.

Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology

TTD: Adrenergic receptor alpha-1D
- Version: 2020.06.01
Alternate Names:

ADRA1D TTD Gene Abbreviation

T53381 TTD Target ID

Gene Info:

Publications:

Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat

NCI: ADRA1D

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.

Campos et al., 2003, Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens., Braz. J. Med. Biol. Res.

Nikolaidis et al., 2006, The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy., J. Am. Coll. Cardiol.

HingoraniCasas: ENSG00000171873
- Version: 31-May-2017
Alternate Names:

ENSG00000171873 Gene Symbol

ADRA1D Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: ADRA1D
- Version: 18-August-2020
Alternate Names:

PA24597 PharmGKB ID

Gene Info:

Publications:
GO: ADRA1D
- Version: 05-September-2020
Alternate Names:

ADRA1A GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRA1D
- Version: 27-Jun-2013
Alternate Names:

146 Gene ID

ADRA1 dGene Synonym

ADRA1A dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Trial Name	tamsulosin, YM-617,Harnal, Flomax
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Specific Action of the Ligand	Inverse agonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	transdermal lidocaine/epinephrine patch,Lidosite
Novel drug target	Established target

Trial Name	PSD-503, phenylephrine
Novel drug target	Established target

ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100]	Description
ADRA1D	Display Id
ENSG00000171873	Ensembl Gene Id

ALPHA-1D ADRENERGIC RECEPTOR	Uniprot Protein Name
ADA1D_HUMAN	Uniprot Id
P25100	Uniprot Accession

binder
agonist (activating)

280	HUGO Gene ID
280	HUGO Gene Symbol
adrenoceptor alpha 1D	HUGO Gene Name

ADRA1D	DrugBank Gene Name
P25100	UniProt Accession
146	Entrez Gene Id

ADRA1D Gene Record

ADRA1D 146 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 17016423 17139284 1972008 9401944

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name alfuzosin,UroXatral Specific Action of the Ligand Antagonist

PMIDs: 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tamsulosin, YM-617,Harnal, Flomax Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 19002123 10393471 18231614 17070143 9223558 18304211

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: binder agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 19493707

Sources: DrugBank GuideToPharmacology PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19300566

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 10592235

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: 18187928 7855217 11682453

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 6123592 8564227

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20412040 17266602 7674815 7582530

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 11752352

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 23364786 20030735 21948594

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources: DrugBank TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
17016423 17139284 1972008 9401944

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

Specific Action of the Ligand Antagonist

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

binder

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
19493707

Sources:
DrugBank GuideToPharmacology PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19300566

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
6123592 8564227

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20412040 17266602 7674815 7582530

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
23364786 20030735 21948594

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist