DGIdb - ADRA1D Gene Record

ADRA1D 146 Druggable Genome

Alternate Names:

146
ADRENOCEPTOR ALPHA 1D
ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
104219
280
ENSG00000171873
OTTHUMG00000031779
P25100
ALPHA-1D ADRENERGIC RECEPTOR
24
α<sub>1D</sub>-adrenoceptor
NP_000669
NM_000678
ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100]
ADA1D_HUMAN
PA24597
Adrenergic receptor alpha-1D
T53381

Gene Info:

GuideToPharmacology Gene Category Name	Adrenoceptors
GuideToPharmacology Gene Category ID	4
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Interpro Name	GPCR, rhodopsin-like, 7TM
Transmembrane Helix Count	7
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Akinaga et al., 2013, Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline., Mol. Pharmacol.
Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
Gaulton et al., 2012, ChEMBL: a large-scale bioactivity database for drug discovery., Nucleic Acids Res.
Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
Zhang D et al., 2004, Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane., Sci China C Life Sci
Koshimizu et al., 2004, Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors., Cardiovasc. Res.
Allinson RW et al., 1990, Reversal of mydriasis by dapiprazole., Ann Ophthalmol
Eltze, 1997, Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D., J. Pharm. Pharmacol.
Greco et al., 2008, The role of combination medical therapy in benign prostatic hyperplasia., Int. J. Impot. Res.
Martin, 1999, Preclinical pharmacology of alpha1-adrenoceptor antagonists., Eur. Urol.
Lepor, 2007, Alpha blockers for the treatment of benign prostatic hyperplasia., Rev Urol
Shannon et al., 2006, Effect of alpha1-adrenergic receptors in cardiac pathophysiology., Am. Heart J.
Martin et al., 1997, Comparative alpha-1 adrenoceptor subtype selectivity and functional uroselectivity of alpha-1 adrenoceptor antagonists., J. Pharmacol. Exp. Ther.
Schwinn DA et al., 2008, Alpha1-adrenoceptor subtypes and lower urinary tract symptoms., Int J Urol
Elhilali, 2006, Alfuzosin: an alpha1-receptor blocker for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia., Expert Opin Pharmacother
Faure et al., 1994, Identification of alpha 1-adrenoceptor subtypes present in the human prostate., Life Sci.
Roehrborn, 2001, Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker., Urology
McVary, 2006, BPH: epidemiology and comorbidities., Am J Manag Care
Andersson et al., 1997, Prostatic alpha 1-adrenoceptors and uroselectivity., Prostate
Kenny et al., 1996, Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies., Br. J. Pharmacol.
Lowe, 2004, Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms., Clin Ther
Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.
Shieh et al., 2009, Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats., Acta Pharmacol. Sin.
Cleary et al., 2004, Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens., Br. J. Pharmacol.
Kenny et al., 1995, Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline., Br. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Bishop, 2007, Recent advances in the discovery of alpha1-adrenoceptor agonists., Curr Top Med Chem
Testa et al., 1995, The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta., Life Sci.
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.
Nagaoka et al., 2008, Amino acids of the human alpha1d-adrenergic receptor involved in antagonist binding., J. Pharmacol. Sci.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Yamamoto et al., 2001, alpha(1)-Adrenoceptor subtypes in the mouse mesenteric artery and abdominal aorta., Br. J. Pharmacol.
Michel et al., 2004, Efficacy and safety of tamsulosin in the treatment of urological diseases., Expert Opin Pharmacother
Ishiguro et al., 2002, Identification of binding sites of prazosin, tamsulosin and KMD-3213 with alpha(1)-adrenergic receptor subtypes by molecular modeling., Life Sci.
Taguchi et al., 1997, Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Noble et al., 1997, The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes., Br. J. Pharmacol.
Lowe, 2005, Summary of clinical experiences with tamsulosin for the treatment of benign prostatic hyperplasia., Rev Urol
Tomiyama et al., 2006, [Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]., Yakugaku Zasshi
Zeng et al., 2009, Frontal analysis of cell-membrane chromatography for determination of drug-alpha(1D) adrenergic receptor affinity., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat

ALFUZOSIN ADRA1D

Interaction Score: 2.71

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

Specific Action of the Ligand Antagonist

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
DOXAZOSIN ADRA1D

Interaction Score: 2.71

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
DAPIPRAZOLE ADRA1D

Interaction Score: 2.38

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
17016423 17139284 1972008 9401944

Sources:
TdgClinicalTrial TEND GuideToPharmacology
TAMSULOSIN ADRA1D

Interaction Score: 2.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
TdgClinicalTrial TEND GuideToPharmacology
BUNAZOSIN ADRA1D

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRIMAZOSIN ADRA1D

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ARMODAFINIL ADRA1D

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19300566

Sources:
TTD
METHOXAMINE ADRA1D

Interaction Score: 1.36

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
19493707

Sources:
GuideToPharmacology PharmGKB
SILODOSIN ADRA1D

Interaction Score: 0.9

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
10592235

Sources:
GuideToPharmacology
MOXISYLYTE ADRA1D

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PRAZOSIN ADRA1D

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
TdgClinicalTrial TEND GuideToPharmacology
TERAZOSIN ADRA1D

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
NOREPINEPHRINE ADRA1D

Interaction Score: 0.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB
PERICIAZINE ADRA1D

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
UPIDOSIN ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-123189 ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
A-119637 ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
NS-49 ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
INDORAMIN ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
OXYMETAZOLINE ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
23364786 20030735 21948594

Sources:
GuideToPharmacology
DEBRISOQUIN ADRA1D

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
LEVOMEPROMAZINE ADRA1D

Interaction Score: 0.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15701205 2870716

Sources:
TdgClinicalTrial TEND
PROPIOMAZINE ADRA1D

Interaction Score: 0.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
CHEMBL56331 ADRA1D

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
BETHANIDINE ADRA1D

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
PHENTOLAMINE ADRA1D

Interaction Score: 0.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
15493479 15306222

Sources:
GuideToPharmacology
PROMAZINE ADRA1D

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
EPINEPHRINE ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name transdermal lidocaine/epinephrine patch,Lidosite

Novel drug target Established target

PMIDs:
20857090 20412040 20954794 19730427

Sources:
TdgClinicalTrial PharmGKB
BMY-7378 ADRA1D

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SENREBOTASE ADRA1D

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AGN-214868

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MEDETOMIDINE ADRA1D

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SERTINDOLE ADRA1D

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Serdolect

Novel drug target Established target

PMIDs:
16925508

Sources:
TdgClinicalTrial TEND
PHENYLEPHRINE ADRA1D

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name PSD-503, phenylephrine

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial PharmGKB
PAPAVERINE ADRA1D

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9351495

Sources:
NCI
CHEMBL88272 ADRA1D

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CYPROHEPTADINE ADRA1D

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SPIROXATRINE ADRA1D

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
LEVONORDEFRIN ADRA1D

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
LABETALOL ADRA1D

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
MIANSERIN ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SPIPERONE ADRA1D

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
KETANSERIN ADRA1D

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
RITANSERIN ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DOPAMINE ADRA1D

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISOPROTERENOL ADRA1D

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RISPERIDONE ADRA1D

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOZAPINE ADRA1D

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000171873
- Version: 101_38
Alternate Names:

ADRA1D Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P25100
- Version: 01-August-2011
Alternate Names:

ADA1D_HUMAN Uniprot Id

ADRA1D Gene Symbol

146 Entrez Gene Id

Gene Info:

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Target Main Class Receptors

Publications:
TdgClinicalTrial: P25100
- Version: January-2014
Alternate Names:

ADRA1D Gene Symbol

Gene Info:

Target Subclass GPCR

Target Subclass Rhodopsin

Target Class Receptors

Publications:

RussLampel: ENSG00000171873

Version: 26-July-2011

Alternate Names:

ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100] Description

ADRA1D Display Id

ENSG00000171873 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P25100
- Version: 11-September-2012
Alternate Names:

ALPHA-1D ADRENERGIC RECEPTOR Uniprot Protein Name

ADA1D_HUMAN Uniprot Id

P25100 Uniprot Accession

Gene Info:

Interpro Type Family

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 146
- Version: 29-September-2020
Alternate Names:

280 HUGO Gene ID

280 HUGO Gene Symbol

adrenoceptor alpha 1D HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adrenoceptors

GuideToPharmacology Gene Category ID 4

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-1D
- Version: 2020.06.01
Alternate Names:

ADRA1D TTD Gene Abbreviation

T53381 TTD Target ID

Gene Info:

Publications:

Gerrard P et al., 2007, Mechanisms of modafinil: A review of current research., Neuropsychiatr Dis Treat

NCI: ADRA1D

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.

Campos et al., 2003, Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens., Braz. J. Med. Biol. Res.

Nikolaidis et al., 2006, The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy., J. Am. Coll. Cardiol.

HingoraniCasas: ENSG00000171873
- Version: 31-May-2017
Alternate Names:

ENSG00000171873 Gene Symbol

ADRA1D Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: ADRA1D
- Version: 18-August-2020
Alternate Names:

PA24597 PharmGKB ID

Gene Info:

Publications:
dGene: ADRA1D
- Version: 27-Jun-2013
Alternate Names:

146 Gene ID

ADRA1 dGene Synonym

ADRA1A dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
GO: ADRA1D
- Version: 01-May-2021
Alternate Names:

ADRA1A GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Novel drug target	Established target
Trial Name	alfuzosin,UroXatral
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	tamsulosin, YM-617,Harnal, Flomax
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Specific Action of the Ligand	Inverse agonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	transdermal lidocaine/epinephrine patch,Lidosite
Novel drug target	Established target

Trial Name	PSD-503, phenylephrine
Novel drug target	Established target

ALPHA-1D ADRENERGIC RECEPTOR (ALPHA 1D-ADRENOCEPTOR) (ALPHA 1D- ADRENORECEPTOR) (ALPHA-1A ADRENERGIC RECEPTOR) (ALPHA ADRENERGIC RECEPTOR 1A). [SOURCE:UNIPROT/SWISSPROT;ACC:P25100]	Description
ADRA1D	Display Id
ENSG00000171873	Ensembl Gene Id

ALPHA-1D ADRENERGIC RECEPTOR	Uniprot Protein Name
ADA1D_HUMAN	Uniprot Id
P25100	Uniprot Accession

agonist (activating)
binder

280	HUGO Gene ID
280	HUGO Gene Symbol
adrenoceptor alpha 1D	HUGO Gene Name

ADRA1D Gene Record

ADRA1D 146 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name alfuzosin,UroXatral Specific Action of the Ligand Antagonist

PMIDs: 16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 19002123 10393471 18231614 17070143 9223558 18304211

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 17016423 17139284 1972008 9401944

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tamsulosin, YM-617,Harnal, Flomax Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19300566

Sources: TTD

Interaction Types & Directionality: agonist (activating) binder

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 19493707

Sources: GuideToPharmacology PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 10592235

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: 18187928 7855217 11682453

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 11752352

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name alfuzosin,UroXatral

Specific Action of the Ligand Antagonist

PMIDs:
16553574 8196478 11750253 16613526 9122046 11752352 8799556 15639685

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
19002123 10393471 18231614 17070143 9223558 18304211

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
17016423 17139284 1972008 9401944

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tamsulosin, YM-617,Harnal, Flomax

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
14680444 12270758 8996174 9117115 11752352 16986050 16518087

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
19300566

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
19493707

Sources:
GuideToPharmacology PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
10592235

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
18187928 7855217 11682453

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15451776 7582530 18064417 17266602 7674815 17016423 17139284

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
23364786 20030735 21948594

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND