DGIdb - ADRA2C Gene Record

ADRA2C 152 Druggable Genome

Alternate Names:

152
ADRENOCEPTOR ALPHA 2C
ADRA2C
ADRA2L2
ADRA2RL2
ADRARL2
ALPHA2CAR
104250
283
ENSG00000184160
OTTHUMG00000159830
P18825
ADA2C_HUMAN
Alpha-2 adrenergic receptor subtype C4
Alpha-2CAR
Alpha-2C adrenoceptor
Alpha-2C adrenoreceptor
Alpha-2C adrenergic receptor
27
NM_000683
α<sub>2C</sub>-adrenoceptor
NP_000674
BE0000342
PA37
Adrenergic receptor alpha-2C
T01777

Gene Info:

GuideToPharmacology Gene Category Name	Adrenoceptors
GuideToPharmacology Gene Category ID	4
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Class	Transporters
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Transmembrane Helix Count	7
Target Main Class	Receptors
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	2: Evidence at transcript level
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Acc	IPR000276
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Rump et al., 1995, Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium., Br. J. Pharmacol.
Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
Bruck et al., 2007, Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?, Clin. Pharmacol. Ther.
Shreve et al., 1991, Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine., Eur. J. Pharmacol.
Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Cleary et al., 2002, Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice., Br. J. Pharmacol.
Rizzo et al., 2001, Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein., Eur. J. Pharmacol.
Kalkman et al., 2003, alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs., Eur. J. Pharmacol.
Lalchandani et al., 2002, Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype., J. Pharmacol. Exp. Ther.
Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
Cleary et al., 2005, The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist., Auton Autacoid Pharmacol
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Uys MM et al., 2017, Therapeutic Potential of Selectively Targeting the α<sub>2C</sub>-Adrenoceptor in Cognition, Depression, and Schizophrenia-New Developments and Future Perspective., Front Psychiatry
Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
Prinster et al., 2006, Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors., J. Pharmacol. Exp. Ther.
Zhang et al., 2003, The alpha2C-adrenoceptor modulates GABA release in mouse striatum., Brain Res. Mol. Brain Res.
Orito et al., 2001, alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator., Br. J. Pharmacol.
Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
Jeng et al., 1998, Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons., Psychopharmacology (Berl.)
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
Newman-Tancredi et al., 2002, Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor., J. Pharmacol. Exp. Ther.
Koshimizu et al., 2004, Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors., Cardiovasc. Res.
Trendelenburg et al., 1997, Presynaptic alpha 2A/D-autoreceptors in the brain cortex of Cercopithecus aethiops., Naunyn Schmiedebergs Arch. Pharmacol.
Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
Dale et al., 2007, Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter., Ann Pharmacother
Heijman J et al., 2013, Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation., Clin Med Insights Cardiol
O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One
Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
Tsukamoto et al., 1984, Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action., Biol. Psychiatry
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Dahl et al., 1986, Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding., Biochem. Pharmacol.
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
de Leeuw van Weenen et al., 2010, The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells., Biochem. Pharmacol.
Kobayashi et al., 2003, The sympathomimetic actions of l-ephedrine and d-pseudoephedrine: direct receptor activation or norepinephrine release?, Anesth. Analg.
Rothman et al., 2003, In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates., J. Pharmacol. Exp. Ther.
Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
Frang et al., 2001, Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors., J. Biol. Chem.
Oosterhof et al., 2014, Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization., J. Pharmacol. Exp. Ther.
Li et al., 1994, Agmatine: an endogenous clonidine-displacing substance in the brain., Science
Villamil-Hernández MT et al., 2013, Pharmacological identification of α1- and α2-adrenoceptor subtypes involved in the vasopressor responses induced by ergotamine in pithed rats., Eur J Pharmacol
Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
Nawarskas JJ et al., 2017, Celiprolol: A Unique Selective Adrenoceptor Modulator., Cardiol Rev
Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology

TETRASUL ADRA2C

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ORM-12741 ADRA2C

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BRIMONIDINE ADRA2C

Interaction Score: 0.54

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16757535 12670699 11606316 14610637

Sources:
DrugBank TEND GuideToPharmacology PharmGKB TTD
TETRAHYDROZOLINE ADRA2C

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMEZINIUM ADRA2C

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LURASIDONE ADRA2C

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name lurasidone, SM-13496,Latuda

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
23545936

Sources:
DrugBank TdgClinicalTrial GuideToPharmacology
BUCINDOLOL ADRA2C

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23071495

Sources:
PharmGKB
YOHIMBINE ADRA2C

Interaction Score: 0.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12110610 11226402 12591093 12438517 10611634 16176444

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB
CLONIDINE ADRA2C

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Specific Action of the Ligand Partial agonist

PMIDs:
20833658 11082457

Sources:
DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology PharmGKB
DROXIDOPA ADRA2C

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
18680204 8590979 21173850

Sources:
DrugBank ChemblInteractions
FADOLMIDINE ADRA2C

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMOSULALOL ADRA2C

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOLAZOLINE ADRA2C

Interaction Score: 0.23

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of agonist-stimulated [35S]GTPγS binding

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
9089664

Sources:
DrugBank GuideToPharmacology
XYLOMETAZOLINE ADRA2C

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20030735

Sources:
DrugBank TTD
FENOLDOPAM ADRA2C

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 7670737

Sources:
DrugBank TEND
NOREPINEPHRINE ADRA2C

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND PharmGKB
APRACLONIDINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIMONIDINE TARTRATE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FADOLMIDINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL362051 ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PROPYLHEXEDRINE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METHYLDOPATE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XYLAZINE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLONIDINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TIZANIDINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
FIPAMEZOLE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fipamezole, JP-1730

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

LOFEXIDINE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name lofexidine,BritLofex

Details of the Assay for Interaction Calculated from [3H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α2C-AR.

PMIDs:
None found

Sources:
TdgClinicalTrial TEND GuideToPharmacology

TIZANIDINE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NVD-422, tizanidine oral spray

Novel drug target Established target

Trial Name tizanidine hydrochloride,Zanaflex

PMIDs:
8930173

Sources:
TdgClinicalTrial
DEXMEDETOMIDINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
EPHEDRA ADRA2C

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
14570629 15955613 12954796

Sources:
DrugBank
CELIPROLOL ADRA2C

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
28742547

Sources:
DrugBank
AGMATINE ADRA2C

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
7906055

Sources:
DrugBank
BREXPIPRAZOLE ADRA2C

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
25225185

Sources:
DrugBank
DEBRISOQUIN ADRA2C

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
MOXONIDINE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GUANABENZ ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
GUANABENZ ACETATE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
RILMENIDINE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GUANFACINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APRACLONIDINE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CABERGOLINE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
12388667 18691132 10641988

Sources:
DrugBank GuideToPharmacology
OXYMETAZOLINE ADRA2C

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
20030735

Sources:
DrugBank GuideToPharmacology
BETHANIDINE ADRA2C

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
RAUWOLFIA SERPENTINA ADRA2C

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor alpha antagonist

PMIDs:
None found

Sources:
ChemblInteractions
LEVOMEPROMAZINE ADRA2C

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
6149771 15701205 2870716

Sources:
DrugBank
MIRTAZAPINE ADRA2C

Interaction Score: 0.1

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

Specific Action of the Ligand Antagonist

PMIDs:
3419539 15771415

Sources:
ChemblInteractions GuideToPharmacology
LISURIDE ADRA2C

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
DrugBank GuideToPharmacology
TETRAHYDROZOLINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESMIRTAZAPINE MALEATE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSEROXYLON ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEDETOMIDINE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPHAZOLINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PERGOLIDE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology
SENREBOTASE ADRA2C

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name AGN-214868

PMIDs:
None found

Sources:
TdgClinicalTrial
BROMOCRIPTINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

agonist (activating)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
20138024 18691132 10641988

Sources:
DrugBank GuideToPharmacology
METHAMPHETAMINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name low dose intravenous methamphetamine

Novel drug target Established target

PMIDs:
9551769 15955613

Sources:
DrugBank TdgClinicalTrial
PHENOXYBENZAMINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11395517

Sources:
DrugBank
DIHYDROERGOCRISTINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GUANFACINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
OXYMETAZOLINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RAUWOLSCINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ASENAPINE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
DrugBank TdgClinicalTrial
PIZOTYLINE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
2045831

Sources:
DrugBank
DIPIVEFRIN HYDROCHLORIDE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLAZOLINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENTOLAMINE MESYLATE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXMEDETOMIDINE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
MEPHENTERMINE SULFATE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APOMORPHINE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
18691132

Sources:
DrugBank GuideToPharmacology
ILOPERIDONE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Novel drug target Established target

PMIDs:
None found

Sources:
DrugBank TdgClinicalTrial
ERGOTAMINE ADRA2C

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23707349

Sources:
DrugBank
LABETALOL HYDROCHLORIDE ADRA2C

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENOXYBENZAMINE HYDROCHLORIDE ADRA2C

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYAMPHETAMINE HYDROBROMIDE ADRA2C

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE ADRA2C

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17389667 23997577

Sources:
DrugBank
SPIROXATRINE ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
EPINEPHRINE ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adrenergic receptor agonist

PMIDs:
1346768

Sources:
ChemblInteractions PharmGKB
PALIPERIDONE ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11132243

Sources:
DrugBank
QUETIAPINE ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 17848919 28855875

Sources:
DrugBank
CHEMBL609728 ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
RACEPINEPHRINE ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
PIRIBEDIL ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ERGOLOID MESYLATES ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVONORDEFRIN ADRA2C

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CYCLOBENZAPRINE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PRAZOSIN ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENTOLAMINE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TERGURIDE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ROXINDOLE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
NOREPINEPHRINE BITARTRATE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OCAPERIDONE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ARIPIPRAZOLE ADRA2C

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

other/unknown

Interaction Info:

PMIDs:
17848919 26346901

Sources:
DrugBank
EPINEPHRINE BITARTRATE ADRA2C

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARVEDILOL ADRA2C

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15306222

Sources:
DrugBank
RISPERIDONE ADRA2C

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 15907153 25943458

Sources:
DrugBank
ZIPRASIDONE ADRA2C

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919

Sources:
DrugBank
MIANSERIN ADRA2C

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DOPAMINE ADRA2C

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOXAPINE ADRA2C

Interaction Score: 0.02

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ISOPROTERENOL ADRA2C

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
OLANZAPINE ADRA2C

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

Novel drug target Established target

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial
HALOPERIDOL ADRA2C

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12629531

Sources:
DrugBank
CLOZAPINE ADRA2C

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919

Sources:
DrugBank
CHLORPROMAZINE ADRA2C

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
METHYLDOPA ADRA2C

Interaction Score: 0.0

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000184160
- Version: 101_38
Alternate Names:

ADRA2C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P18825
- Version: January-2014
Alternate Names:

ADRA2C Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P18825
- Version: 01-August-2011
Alternate Names:

ADRA2C Gene Symbol

ADA2C_HUMAN Uniprot Id

ENSG00000184160 Ensembl Gene Id

Gene Info:

Target Subclass Rhodopsin

Transmembrane Helix Count 7

Target Main Class Receptors

Publications:
HopkinsGroom: P18825
- Version: 11-September-2012
Alternate Names:

ALPHA-2C ADRENERGIC RECEPTOR Uniprot Protein Name

152 Entrez Gene Id

ADA2C_HUMAN Uniprot Id

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 2: Evidence at transcript level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 152
- Version: 29-September-2020
Alternate Names:

283 HUGO Gene ID

283 HUGO Gene Symbol

adrenoceptor alpha 2C HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Adrenoceptors

GuideToPharmacology Gene Category ID 4

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

PharmGKB: ADRA2C

Version: 18-August-2020

Alternate Names:

PA37 PharmGKB ID

Gene Info:

Publications:

O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One

Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut

DrugBank: BE0000342

Version: 5.1.7

Alternate Names:

ADRA2C DrugBank Gene Name

P18825 UniProt Accession

152 Entrez Gene Id

Gene Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Shreve et al., 1991, Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine., Eur. J. Pharmacol.

HingoraniCasas: ENSG00000184160
- Version: 31-May-2017
Alternate Names:

ENSG00000184160 Gene Symbol

ADRA2C Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADRA2L2
- Version: chembl_23
Alternate Names:

ADRA2RL2 GENE_SYMBOL

ADRA2C GENE_SYMBOL

Alpha-2C adrenergic receptor UNIPROT

Gene Info:

Publications:
GO: ADRA2C
- Version: 05-September-2020
Alternate Names:

ADRA2L2 GO Gene Synonym

ADRA2RL2 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: ADRA2C
- Version: 27-Jun-2013
Alternate Names:

152 Gene ID

ADRA2L2 dGene Synonym

ADRA2RL2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adrenergic receptor alpha-2C
- Version: 2020.06.01
Alternate Names:

ADRA2C TTD Gene Abbreviation

T01777 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	lurasidone, SM-13496,Latuda
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

Mechanism of Interaction	Adrenergic receptor alpha-2 agonist
Direct Interaction	yes
Specific Action of the Ligand	Partial agonist

Mechanism of Interaction	Adrenergic receptor agonist
Direct Interaction	yes

Details of the Assay for Interaction	Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Trial Name	fipamezole, JP-1730
Novel drug target	Established target

Trial Name	NVD-422, tizanidine oral spray
Novel drug target	Established target
Trial Name	tizanidine hydrochloride,Zanaflex

Direct Interaction	yes
Mechanism of Interaction	Adrenergic receptor alpha antagonist

Mechanism of Interaction	Adrenergic receptor alpha-2 antagonist
Direct Interaction	yes
Specific Action of the Ligand	Antagonist

Mechanism of Interaction	Adrenergic receptor alpha agonist
Direct Interaction	yes

binder
antagonist (inhibitory)

Trial Name	low dose intravenous methamphetamine
Novel drug target	Established target

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Novel drug target	Established target

Mechanism of Interaction	Adrenergic receptor antagonist
Direct Interaction	yes

Trial Name	olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
Novel drug target	Established target
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ADRA2C	Gene Symbol
ADA2C_HUMAN	Uniprot Id
ENSG00000184160	Ensembl Gene Id

ALPHA-2C ADRENERGIC RECEPTOR	Uniprot Protein Name
152	Entrez Gene Id
ADA2C_HUMAN	Uniprot Id

283	HUGO Gene ID
283	HUGO Gene Symbol
adrenoceptor alpha 2C	HUGO Gene Name

ADRA2C	DrugBank Gene Name
P18825	UniProt Accession
152	Entrez Gene Id

ADRA2RL2	GENE_SYMBOL
ADRA2C	GENE_SYMBOL
Alpha-2C adrenergic receptor	UNIPROT

ADRA2C Gene Record

ADRA2C 152 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 16757535 12670699 11606316 14610637

Sources: DrugBank TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name lurasidone, SM-13496,Latuda Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 23545936

Sources: DrugBank TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23071495

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 12110610 11226402 12591093 12438517 10611634 16176444

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes Specific Action of the Ligand Partial agonist

PMIDs: 20833658 11082457

Sources: DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor agonist Direct Interaction yes

PMIDs: 18680204 8590979 21173850

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of agonist-stimulated [<sup>35</sup>S]GTP&gamma;S binding Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 9089664

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20030735

Sources: DrugBank TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17016423 17139284 7670737

Sources: DrugBank TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources: DrugBank TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adrenergic receptor alpha-2 agonist Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16757535 12670699 11606316 14610637

Sources:
DrugBank TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name lurasidone, SM-13496,Latuda

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
23545936

Sources:
DrugBank TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23071495

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12110610 11226402 12591093 12438517 10611634 16176444

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

Specific Action of the Ligand Partial agonist

PMIDs:
20833658 11082457

Sources:
DrugBank TdgClinicalTrial ChemblInteractions GuideToPharmacology PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor agonist

Direct Interaction yes

PMIDs:
18680204 8590979 21173850

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of agonist-stimulated [<sup>35</sup>S]GTPγS binding

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
9089664

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20030735

Sources:
DrugBank TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17016423 17139284 7670737

Sources:
DrugBank TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8590979 1980236 17410123 1654268 18064417 17016423 17139284

Sources:
DrugBank TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adrenergic receptor alpha-2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False