• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ADRA2C Gene Record

  • Summary
  • Interactions
  • Claims
  • ADRA2C 152 Druggable Genome

    Alternate Names:

    152
    ADRENOCEPTOR ALPHA 2C
    ADRA2C
    ADRA2L2
    ADRA2RL2
    ADRARL2
    ALPHA2CAR
    104250
    283
    ENSG00000184160
    OTTHUMG00000159830
    P18825
    ADA2C_HUMAN
    Alpha-2 adrenergic receptor subtype C4
    Alpha-2CAR
    Alpha-2C adrenoceptor
    Alpha-2C adrenoreceptor
    Alpha-2C adrenergic receptor
    PA37
    Adrenergic receptor alpha-2C
    T01777

    Gene Info:

    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Class Transporters
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Acc IPR000276
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Rump et al., 1995, Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium., Br. J. Pharmacol.
    Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
    Bruck et al., 2007, Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?, Clin. Pharmacol. Ther.
    Shreve et al., 1991, Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine., Eur. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Cleary et al., 2002, Investigation of neurotransmission in vas deferens from alpha(2A/D)-adrenoceptor knockout mice., Br. J. Pharmacol.
    Rizzo et al., 2001, Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein., Eur. J. Pharmacol.
    Kalkman et al., 2003, alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs., Eur. J. Pharmacol.
    Lalchandani et al., 2002, Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype., J. Pharmacol. Exp. Ther.
    Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
    Cleary et al., 2005, The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist., Auton Autacoid Pharmacol
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Piletz et al., 1996, Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes., J. Pharmacol. Exp. Ther.
    Haenisch et al., 2010, Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline., Fundam Clin Pharmacol
    Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
    Prinster et al., 2006, Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors., J. Pharmacol. Exp. Ther.
    Zhang et al., 2003, The alpha2C-adrenoceptor modulates GABA release in mouse striatum., Brain Res. Mol. Brain Res.
    Orito et al., 2001, alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator., Br. J. Pharmacol.
    Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
    Martin et al., 1995, Renal vasodilatation by dopexamine and fenoldopam due to alpha 1-adrenoceptor blockade., Br. J. Pharmacol.
    Jeng et al., 1998, Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons., Psychopharmacology (Berl.)
    Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
    de Boer et al., 1988, Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers., Neuropharmacology
    Fernández et al., 2005, Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents., J. Med. Chem.
    O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One
    Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut
    Millan MJ et al., 2000, S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine., J Pharmacol Exp Ther
    George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
    Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
    Davis, 2010, Recent advances in the treatment of pain., F1000 Med Rep
  • YOHIMBINE   ADRA2C

    Interaction Score: 1.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12110610 11226402 12591093 12438517 10611634 16176444


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • TETRASUL   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PROPYLHEXEDRINE   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ORM-12741   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • XYLOMETAZOLINE   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    20030735


    Sources:
    TTD

  • TETRAHYDROZOLINE   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMEZINIUM   ADRA2C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BRIMONIDINE   ADRA2C

    Interaction Score: 0.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16757535 12670699 11606316 14610637


    Sources:
    TEND PharmGKB TTD

  • BUCINDOLOL   ADRA2C

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23071495


    Sources:
    PharmGKB

  • CLONIDINE   ADRA2C

    Interaction Score: 0.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes
    Trial Name ARC-4558, 0.1% clonidine hycrochloride gel

    PMIDs:
    20833658 11082457


    Sources:
    TdgClinicalTrial ChemblInteractions PharmGKB

  • DROXIDOPA   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    18680204 8590979 21173850


    Sources:
    ChemblInteractions

  • FADOLMIDINE   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FENOLDOPAM   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17016423 17139284 7670737


    Sources:
    TEND

  • LOFEXIDINE   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name lofexidine,BritLofex

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • AMOSULALOL   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TIZANIDINE   ADRA2C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name NVD-422, tizanidine oral spray
    Novel drug target Established target
    Trial Name tizanidine hydrochloride,Zanaflex

    PMIDs:
    8930173


    Sources:
    TdgClinicalTrial

  • NOREPINEPHRINE   ADRA2C

    Interaction Score: 0.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8590979 1980236 17410123 1654268 18064417 17016423 17139284


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • LURASIDONE   ADRA2C

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name lurasidone, SM-13496,Latuda
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial

  • APRACLONIDINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MOXONIDINE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DEBRISOQUIN   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • BRIMONIDINE TARTRATE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FADOLMIDINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHYLDOPATE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RILMENIDINE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLONIDINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIZANIDINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FIPAMEZOLE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name fipamezole, JP-1730
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DEXMEDETOMIDINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GUANABENZ ACETATE   ADRA2C

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIHYDROERGOCRISTINE   ADRA2C

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BETHANIDINE   ADRA2C

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • GUANFACINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CYCLOBENZAPRINE   ADRA2C

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RAUWOLFIA SERPENTINA   ADRA2C

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor alpha antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRAHYDROZOLINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESMIRTAZAPINE MALEATE   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALSEROXYLON   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEDETOMIDINE   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NAPHAZOLINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SENREBOTASE   ADRA2C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name AGN-214868

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MIRTAZAPINE   ADRA2C

    Interaction Score: 0.16

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    3419539 15771415


    Sources:
    ChemblInteractions

  • OXYMETAZOLINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIPIVEFRIN HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLAZOLINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENTOLAMINE MESYLATE   ADRA2C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPHENTERMINE SULFATE   ADRA2C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHAMPHETAMINE   ADRA2C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name low dose intravenous methamphetamine
    Novel drug target Established target

    PMIDs:
    9551769 15955613


    Sources:
    TdgClinicalTrial

  • LABETALOL HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENOXYBENZAMINE HYDROCHLORIDE   ADRA2C

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROXYAMPHETAMINE HYDROBROMIDE   ADRA2C

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASENAPINE   ADRA2C

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814


    Sources:
    TdgClinicalTrial

  • EPINEPHRINE   ADRA2C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    1346768


    Sources:
    ChemblInteractions PharmGKB

  • LEVONORDEFRIN   ADRA2C

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERGOLOID MESYLATES   ADRA2C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NOREPINEPHRINE BITARTRATE   ADRA2C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ILOPERIDONE   ADRA2C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • EPINEPHRINE BITARTRATE   ADRA2C

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOPAMINE   ADRA2C

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHYLDOPA   ADRA2C

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor alpha-2 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOPROTERENOL   ADRA2C

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OLANZAPINE   ADRA2C

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
    Novel drug target Established target
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000184160

    • Version: 101_38

    Alternate Names:
    ADRA2C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P18825

    • Version: January-2014

    Alternate Names:
    ADRA2C Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P18825

    • Version: 01-August-2011

    Alternate Names:
    ADRA2C Gene Symbol
    ADA2C_HUMAN Uniprot Id
    ENSG00000184160 Ensembl Gene Id

    Gene Info:
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7
    Target Main Class Receptors

    Publications:

  • HopkinsGroom: P18825

    • Version: 11-September-2012

    Alternate Names:
    ALPHA-2C ADRENERGIC RECEPTOR Uniprot Protein Name
    152 Entrez Gene Id
    ADA2C_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 2: Evidence at transcript level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADRA2C

    • Version: 18-August-2020

    Alternate Names:
    PA37 PharmGKB ID

    Gene Info:

    Publications:
    O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One
    Yang YY et al., 2010, Association of the G-protein and α2-adrenergic receptor gene and plasma norepinephrine level with clonidine improvement of the effects of diuretics in patients with cirrhosis with refractory ascites: a randomised clinical trial., Gut

  • HingoraniCasas: ENSG00000184160

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000184160 Gene Symbol
    ADRA2C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ADRA2L2

    • Version: chembl_23

    Alternate Names:
    ADRA2RL2 GENE_SYMBOL
    ADRA2C GENE_SYMBOL
    Alpha-2C adrenergic receptor UNIPROT

    Gene Info:

    Publications:

  • GO: ADRA2C

    • Version: 01-February-2022

    Alternate Names:
    ADRA2L2 GO Gene Synonym
    ADRA2RL2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: ADRA2C

    • Version: 27-Jun-2013

    Alternate Names:
    152 Gene ID
    ADRA2L2 dGene Synonym
    ADRA2RL2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Adrenergic receptor alpha-2C

    • Version: 2020.06.01

    Alternate Names:
    ADRA2C TTD Gene Abbreviation
    T01777 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21