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ADRB2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ADRB2 154 Druggable Genome

    Alternate Names:

    154
    ADRENOCEPTOR BETA 2
    ADRB2
    ADRB2R
    ADRBR
    B2AR
    BAR
    BETA2AR
    109690
    286
    ENSG00000169252
    OTTHUMG00000129933
    Beta-2 adrenergic receptor
    Beta-2 adrenoreceptor
    Beta-2 adrenoceptor
    BETA-2 ADRENERGIC RECEPTOR (BETA-2 ADRENOCEPTOR) (BETA-2 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P07550]
    PA39
    P07550
    ADRB2_HUMAN
    Adrenergic receptor beta-2
    T52522

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
    Brodde et al., 1986, Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes., J. Cardiovasc. Pharmacol.
    Brodde et al., 1985, Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the "intrinsic sympathomimetic activity"., Naunyn Schmiedebergs Arch. Pharmacol.
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Tarizzo et al., 1994, Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat., Naunyn Schmiedebergs Arch. Pharmacol.
    Mersmann, 1998, Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action., J. Anim. Sci.
    El-Armouche et al., 2009, Beta-adrenergic stimulation and myocardial function in the failing heart., Heart Fail Rev
    Sanders, 1998, The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function., Adv. Exp. Med. Biol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Joseph et al., 2004, Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers., Naunyn Schmiedebergs Arch. Pharmacol.
    Yalcin et al., 2009, beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain., Ann. Neurol.
    Doggrell, 1993, The effects of (+/-)-, (+)-, and (-)-atenolol, sotalol, and amosulalol on the rat left atria and portal vein., Chirality
    Lowe et al., 2002, Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium., Br. J. Pharmacol.
    Juberg et al., 1985, Beta 1- and beta 2-adrenoceptor binding and functional response in right and left atria of rat heart., Naunyn Schmiedebergs Arch. Pharmacol.
    Prinz et al., 2001, beta-adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia., Brain Res.
    Sekut et al., 1995, Anti-inflammatory activity of salmeterol: down-regulation of cytokine production., Clin. Exp. Immunol.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Fujita et al., 1998, Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor., Neurosci. Lett.
    Wheeldon et al., 1994, The effects of lower than conventional doses of oral nadolol on relative beta 1/beta 2-adrenoceptor blockade., Br J Clin Pharmacol
    Liu et al., 1995, Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans., Int. J. Obes. Relat. Metab. Disord.
    Wheeldon et al., 1992, Evaluation of in vivo partial beta 1/beta 2-agonist activity: a dose-ranging study with carteolol., Br J Clin Pharmacol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
    Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
    Brogden et al., Salmeterol xinafoate: a review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease., Allergol Immunopathol (Madr)
    Finney et al., 2001, Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)., Br. J. Pharmacol.
    Rong et al., 1999, Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol., Biochemistry
    Green et al., 2001, The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s)., Eur. J. Pharmacol.
    Meliton et al., 2003, Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils., J. Allergy Clin. Immunol.
    Zuurhout MJ et al., 2013, Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort., Pharmacogenomics
    Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
    Wechsler ME et al., 2009, Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial., Lancet
    Basu K et al., 2009, Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol., J Allergy Clin Immunol
    Bleecker ER et al., 2007, Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies., Lancet
    Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet
    Cazzola M et al., 2002, Clinical pharmacokinetics of salmeterol., Clin Pharmacokinet
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Rouget et al., 2006, Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia., Biol. Reprod.
    Isaza et al., 2005, Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population., Methods Find Exp Clin Pharmacol
    Horinouchi et al., 2007, Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol., Life Sci.
    Illingworth et al., 2006, Classical polarization in hybrid QM/MM methods., J Phys Chem A
    Rosendorff, 1993, Beta-blocking agents with vasodilator activity., J Hypertens Suppl
    Doggrell, 1988, Relaxant and beta 2-adrenoceptor blocking activities of labetalol, dilevalol, amosulalol and KF-4317 on the rat isolated aorta., J. Pharm. Pharmacol.
    Sassard et al., 1983, [Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient]., J Pharmacol
    Doggrell, 1992, The effects of labetalol and dilevalol on isolated cardiovascular preparations of the guinea-pig and rat., J. Pharm. Pharmacol.
    van Zwieten, 1993, An overview of the pharmacodynamic properties and therapeutic potential of combined alpha- and beta-adrenoceptor antagonists., Drugs
    Pujos et al., 2009, Comparison of the analysis of beta-blockers by different techniques., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Ferro et al., 1997, A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects., Br J Clin Pharmacol
    Fuchsjager-Mayrl et al., 2005, Polymorphism of the beta-2 adrenoceptor and IOP lowering potency of topical timolol in healthy subjects., Mol. Vis.
    Borger et al., 1998, Beta-adrenoceptor-mediated inhibition of IFN-gamma, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the beta2-adrenoceptor subtype., Am. J. Respir. Cell Mol. Biol.
    Rotmensch et al., 1993, Comparisons of beta-adrenergic blocking properties of S- and R-timolol in humans., J Clin Pharmacol
    Van der Graaf et al., 1995, Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries., Br. J. Pharmacol.
    Chong et al., 2003, Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells., Br. J. Pharmacol.
    Hochhaus et al., 1992, Pharmacokinetic/pharmacodynamic characteristics of the beta-2-agonists terbutaline, salbutamol and fenoterol., Int J Clin Pharmacol Ther Toxicol
    Cooperberg et al., 2008, Terbutaline and the prevention of nocturnal hypoglycemia in type 1 diabetes., Diabetes Care
    Riether et al., 2011, Stimulation of β₂-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction., Brain Behav. Immun.
    Ramer-Quinn et al., 2000, Cytokine production by naive and primary effector CD4+ T cells exposed to norepinephrine., Brain Behav. Immun.
    Schäfers et al., 1999, Disodium cromoglycate does not prevent terbutaline-induced desensitization of beta 2-adrenoceptor-mediated cardiovascular in vivo functions in human volunteers., J. Cardiovasc. Pharmacol.
    Haahtela et al., 1991, Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma., N. Engl. J. Med.
    Nakamura et al., 2001, Activation of beta(2)-adrenoceptor prevents shiga toxin 2-induced TNF-alpha gene transcription., J. Am. Soc. Nephrol.
    Zetterlund et al., 2001, beta2-Adrenoceptor desensitization in human alveolar macrophages induced by inhaled terbutaline in vivo is not counteracted by budesonide., Clin. Sci.
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
    Dishy V et al., 2001, The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization., N Engl J Med
    Sato et al., 2004, Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger., J. Mol. Cell. Cardiol.
    Angers et al., 2001, Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells., Life Sci.
    Ding et al., 2000, Modulation of porcine adipocyte beta-adrenergic receptors by a beta-adrenergic agonist., J. Anim. Sci.
    Skoumbourdis AP et al., 2009, Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors., Bioorg Med Chem Lett
    Ahlquist, 1976, Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor., Am. Heart J.
    Jones et al., 2003, Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer., BMC Pharmacol.
    Odley et al., 2004, Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling., Proc. Natl. Acad. Sci. U.S.A.
    Uezono et al., 2004, Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system., Am. J. Physiol., Cell Physiol.
    Teixeira et al., 2004, Atypical beta-adrenoceptor subtypes mediate relaxations of rabbit corpus cavernosum., J. Pharmacol. Exp. Ther.
    Abraham et al., 2003, Pharmacological and biochemical characterization of the beta-adrenergic signal transduction pathway in different segments of the respiratory tract., Biochem. Pharmacol.
    Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One
    Brichetto et al., 2003, Beclomethasone rapidly ablates allergen-induced beta 2-adrenoceptor pathway dysfunction in human isolated bronchi., Am. J. Physiol. Lung Cell Mol. Physiol.
    Brouri et al., 2004, Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis., Eur. J. Pharmacol.
    Yamanishi et al., 2003, Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro., Neurourol. Urodyn.
    Choudhry et al., 2005, Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma., Am. J. Respir. Crit. Care Med.
    Bouyssou et al., 2010, Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models., J. Pharmacol. Exp. Ther.
    Handley et al., 2002, Biological actions of formoterol isomers., Pulm Pharmacol Ther
    Faulds et al., 1991, Formoterol. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease., Drugs
    Scola et al., 2004, Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol., Br. J. Pharmacol.
    Bartow et al., 1998, Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma., Drugs
    Cheer et al., 2002, Formoterol: a review of its use in chronic obstructive pulmonary disease., Am J Respir Med
    Ryall et al., 2006, Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses., Br. J. Pharmacol.
    Löfdahl et al., 1989, Formoterol fumarate, a new beta 2-adrenoceptor agonist. Acute studies of selectivity and duration of effect after inhaled and oral administration., Allergy
    Kompa et al., 1995, Beta-adrenoceptor regulation and functional responses in the guinea-pig following chronic administration of the long-acting beta 2-adrenoceptor agonist formoterol., Naunyn Schmiedebergs Arch. Pharmacol.
    Steiropoulos et al., 2008, Formoterol in the management of chronic obstructive pulmonary disease., Int J Chron Obstruct Pulmon Dis
    Op't Holt, 2007, Inhaled beta agonists., Respir Care
    Hoffmann et al., 2004, Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells., Naunyn Schmiedebergs Arch. Pharmacol.
    Rosberg et al., 1993, Bambuterol and terbutaline in human cerebrospinal fluid and plasma., Eur. J. Clin. Pharmacol.
    Waldeck, 2002, Beta-adrenoceptor agonists and asthma--100 years of development., Eur. J. Pharmacol.
    Svensson, 1988, Bambuterol, a bronchodilator prodrug with sustained action, enhances delivery of active drug to the lung., Agents Actions Suppl.
    Coleman et al., 1996, Exosites: their current status, and their relevance to the duration of action of long-acting beta 2-adrenoceptor agonists., Trends Pharmacol. Sci.
    Zhang et al., 2007, Enantiomeric separation of beta2-agonists on macrocyclic antibiotic chiral stationary phases in high performance liquid chromatography., Pharmazie
    Chou et al., 2010, Effects of bambuterol and terbutaline on isolated rat's tracheal smooth muscle., Eur Arch Otorhinolaryngol
    Park HW et al., 2009, Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response., Allergy
    Arai et al., 2003, Beta-adrenergic receptor agonists and antagonists counteract LPS-induced neuronal death in retinal cultures by different mechanisms., Brain Res.
    Drímal et al., 1987, External transport of beta-adrenergic binding sites in ischemic myocardium., Gen. Physiol. Biophys.
    Bilcíková et al., 1987, The action of adrenoceptor agonists and antagonists on the guinea pig and dog trachea., Gen. Physiol. Biophys.
    Noack, 1986, [Antiglaucomatous effectiveness of beta receptor blockers with special reference to metipranolol]., Klin Monbl Augenheilkd
    Nuttall et al., 2003, A comparison of the beta1-selectivity of three beta1-selective beta-blockers., J Clin Pharm Ther
    Iaccarino G et al., 2005, beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene., Pharmacogenomics J
    Kim KM et al., 2012, Pharmacogenetics and healthcare outcomes in patients with chronic heart failure., Eur J Clin Pharmacol
    Wheeldon et al., 1991, The effect of pindolol on creatine kinase is not due to beta 2-adrenoceptor partial agonist activity., Br J Clin Pharmacol
    Rubenstein et al., 2006, Molecular dynamics of a biophysical model for beta2-adrenergic and G protein-coupled receptor activation., J. Mol. Graph. Model.
    Dejgaard et al., 1991, Adrenergic receptors are a fallible index of adrenergic denervation hypersensitivity., Scand. J. Clin. Lab. Invest.
    Doggrell, 1991, Effects of (+/-)- (+)- and (-)-metoprolol, (+/-)- (+)- and (-)-pindolol, (+/-)-mepindolol and (+/-)-bopindolol on the rat left atria and portal vein., Gen. Pharmacol.
    Doggrell, 1990, Relaxant and beta 2-adrenoceptor blocking activities of (+/- )-, (+)- and (-)-pindolol on the rat isolated aorta., J. Pharm. Pharmacol.
    Ryall et al., 2002, Beta 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Zhu et al., 2001, Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia., Neuroscience
    Choo et al., 1992, Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation., Am. J. Physiol.
    Sillence et al., 1991, Effects of clenbuterol, ICI118551 and sotalol on the growth of cardiac and skeletal muscle and on beta 2-adrenoceptor density in female rats., Naunyn Schmiedebergs Arch. Pharmacol.
    Mazzanti et al., 2007, A pharmacodynamic study on clenbuterol-induced toxicity: beta1- and beta2-adrenoceptors involvement in guinea-pig tachycardia in an in vitro model., Food Chem. Toxicol.
    Sehrt D et al., 2011, Carvedilol pharmacokinetics and pharmacodynamics in relation to CYP2D6 and ADRB pharmacogenetics., Pharmacogenomics
    Metra M et al., 2010, Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure., Cardiovasc Drugs Ther
    de Groote P et al., 2005, Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure., Pharmacogenet Genomics
    Kaye et al., 2003, Beta-adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure., Pharmacogenetics
    Maebara et al., 2002, Nightmares and panic disorder associated with carvedilol overdose., Ann Pharmacother
    Irodova et al., 2002, [Carvedilol in treating primary pulmonary hypertension patients: effect on severity of cardiac failure, degree of pulmonary hypertension, concentration of catecholamines in blood plasma and dependence of cyclic AMP synthesis in lymphocytes on beta-adrenergic receptors]., Ter. Arkh.
    Okajima et al., 2004, Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats., J. Pharmacol. Exp. Ther.
    Nichols et al., 1991, Studies on the mechanism of arterial vasodilation produced by the novel antihypertensive agent, carvedilol., Fundam Clin Pharmacol
    Gelmont et al., 1988, Hypokalemia induced by inhaled bronchodilators., Chest
    Singh et al., 1996, Beta 2-adrenergic function in cultured rat proximal tubule epithelial cells., Am. J. Physiol.
    Hu et al., 2000, Influence of autonomic neurotransmitters on human uveal melanocytes in vitro., Exp. Eye Res.
    Fitch, The use of anti-asthmatic drugs. Do they affect sports performance?, Sports Med
    Kimura et al., 1999, Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists., J. Pharmacol. Exp. Ther.
    Cazzola et al., 2005, Ultra long-acting beta 2-agonists in development for asthma and chronic obstructive pulmonary disease., Expert Opin Investig Drugs
    Bruck et al., 2004, Beta 2-adrenoceptor-mediated intrinsic sympathomimetic activity of carteolol: an in vivo study., Naunyn Schmiedebergs Arch. Pharmacol.
    Marone et al., 1984, Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol., Int. Arch. Allergy Appl. Immunol.
    Coqueret et al., 1996, Role of cyclic AMP in the modulation of IgE production by the beta 2-adrenoceptor agonist, fenoterol., Eur. Respir. J.
    Boterman et al., 2006, Protein kinase C potentiates homologous desensitization of the beta2-adrenoceptor in bovine tracheal smooth muscle., Eur. J. Pharmacol.
    Bouillon et al., 1996, Concentration-effect relationship of the positive chronotropic and hypokalaemic effects of fenoterol in healthy women of childbearing age., Eur. J. Clin. Pharmacol.
    de Vries et al., 2001, Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle., Eur. J. Pharmacol.
    Hjorth et al., 1996, Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo., Eur. J. Pharmacol.
    Hjorth et al., 1993, In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol., J. Pharmacol. Exp. Ther.
    Frishman et al., 1990, Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism., J Clin Pharmacol
    Sánchez, 1993, Effect of serotonergic drugs on footshock-induced ultrasonic vocalization in adult male rats., Behav Pharmacol
    Ijzerman et al., 1987, The membrane stabilizing activity of beta-adrenoceptor ligands. Quantitative evaluation of the interaction of phenoxypropanolamines with the [3H]batrachotoxinin A 20-alpha-benzoate binding site on voltage-sensitive sodium channels in rat brain., Biochem. Pharmacol.
    Kulkarni et al., 1977, Beta-2 adrenoceptor blocking activity of penbutolol and propranolol at very low doses., Clin. Pharmacol. Ther.
    Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
    Zebrack et al., 2009, Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial., Pharmacotherapy
    Bjermer L et al., 2015, Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)., Drug Des Devel Ther
    Vansal et al., 1999, Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes., Biochem. Pharmacol.
    Matsumoto et al., 1994, Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice., Pharmacol. Biochem. Behav.
    Osadchii et al., 2007, Temporal changes in myocardial adrenergic regulation with the progression to pump dysfunction after chronic beta-adrenoreceptor activation in rats., Pflugers Arch.
    Prenner et al., 2007, Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy., Biochemistry
    Sapena et al., 1996, Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes., Eur. J. Pharmacol.
    Abadie et al., 1996, Modulation of noradrenaline release from isolated human atrial appendages., J. Auton. Nerv. Syst.
    Carie et al., 2007, A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway., Oncogene
    Leier et al., 1982, Intravenous pirbuterol., Clin. Pharmacol. Ther.
    Hamdad et al., 1996, Beta 2-adrenergic dilation of conductance coronary arteries involves flow-dependent NO formation in conscious dogs., Am. J. Physiol.
    Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.
    Huang G et al., 2004, Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese., Clin Exp Hypertens
    Lucin et al., 2007, Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation., Exp. Neurol.
    Reiner S et al., 2010, Differential signaling of the endogenous agonists at the beta2-adrenergic receptor., J Biol Chem
    Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg
    Noguchi et al., 1991, Cardiac effects of beta-2 adrenoceptor stimulation with intracoronary procaterol in the absence and presence of regional myocardial ischemia in dogs., J. Pharmacol. Exp. Ther.
    Brodde et al., 1990, Agonist-induced desensitization of beta-adrenoceptor function in humans. Subtype-selective reduction in beta 1- or beta 2-adrenoceptor-mediated physiological effects by xamoterol or procaterol., Circulation
    Kobayashi et al., 2002, [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]., Nihon Kokyuki Gakkai Zasshi
    Aizawa et al., 1991, Effects of procaterol, a beta-2-adrenoceptor stimulant, on neuroeffector transmission in human bronchial tissue., Respiration
    Yamasaki et al., 2004, [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance]., Nihon Kokyuki Gakkai Zasshi
    Statler AK et al., 2020, Ephedrine,
    Cazzola et al., 2010, Arformoterol tartrate in the treatment of COPD., Expert Rev Respir Med
    2004, Arformoterol: (R,R)-eformoterol, (R,R)-formoterol, arformoterol tartrate, eformoterol-sepracor, formoterol-sepracor, R,R-eformoterol, R,R-formoterol., Drugs R D
    Matera et al., 2007, ultra-long-acting beta2-adrenoceptor agonists: an emerging therapeutic option for asthma and COPD?, Drugs
    Baumgartner et al., 2007, Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial., Clin Ther
    Kharidia et al., 2008, A pharmacokinetic/pharmacodynamic study comparing arformoterol tartrate inhalation solution and racemic formoterol dry powder inhaler in subjects with chronic obstructive pulmonary disease., Pulm Pharmacol Ther
    Quast et al., 1984, Binding of beta-adrenoceptor antagonists to rat and rabbit lung: special reference to levobunolol., Arzneimittelforschung
    Brooks et al., Ocular beta-blockers in glaucoma management. Clinical pharmacological aspects., Drugs Aging
    Harris et al., 1994, Correlates of acute exercise-induced ocular hypotension., Invest. Ophthalmol. Vis. Sci.
    Sharif et al., 2001, Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes., J Ocul Pharmacol Ther
    Gonzalez et al., 1987, Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy., Drugs
    Lesar, 1987, Comparison of ophthalmic beta-blocking agents., Clin Pharm
    Bianchetti et al., 1990, In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon., Br. J. Pharmacol.
    Schwarz et al., 2003, Preterm labour: an overview of current and emerging therapeutics., Curr. Med. Chem.
    Lye et al., 1992, Failure of ritodrine to prevent preterm labor in the sheep., Am. J. Obstet. Gynecol.
    Tanaka et al., 2001, Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence., J. Med. Chem.
    Lenselink et al., 1994, Cardiovascular teratogenicity of terbutaline and ritodrine in the chick embryo., Am. J. Obstet. Gynecol.
    Weinshenker et al., 2001, Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine., J. Pharmacol. Exp. Ther.
    Skrabal et al., 1989, Inverse regulation of alpha-2 and beta-2 adrenoceptors in salt-sensitive hypertension: an hypothesis., Life Sci.
    Iaccarino G et al., 2006, Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension., Clin Pharmacol Ther
    Blake K et al., 2013, Methacholine PC20 in African Americans and whites with asthma with homozygous genotypes at ADRB2 codon 16., Pulm Pharmacol Ther
    Gaulton et al., 2012, ChEMBL: a large-scale bioactivity database for drug discovery., Nucleic Acids Res.
  • TERBUTALINE   ADRB2

    Interaction Score: 6.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12569076 1358833 18782903 20674738 11120594 10226872 2062329 11752352 11675405 11256987


    Sources:
    TdgClinicalTrial TEND TTD

  • CLENBUTEROL   ADRB2

    Interaction Score: 5.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12388476 11720783 1322047 11752352 1685013 17449161 16680159


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • FENOTEROL   ADRB2

    Interaction Score: 4.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6203844 8777955 16324695 8911881 11730729 11752352


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • METAPROTERENOL   ADRB2

    Interaction Score: 4.35

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    3168573 8760245 10973730 11752352 2870555 10490901


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • BAMBUTEROL   ADRB2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8223836 12065188 3262993 8885698 18065099 11752352 20012638


    Sources:
    TTD

  • FORMOTEROL   ADRB2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name budesonide + formoterol,Symbicort
    Novel drug target Established target
    Trial Name CHF-1535, beclomethasone dipropionate + formoterol fumarate

    PMIDs:
    12090787 1718682 14662724 9506248 14720051 16432501 2544117 7675115 18686730 11752352 17594727 14730417


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • RITODRINE   ADRB2

    Interaction Score: 2.42

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1976401 12871140 1332478 11311067 8059831 11752352


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • PIRBUTEROL   ADRB2

    Interaction Score: 2.42

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11752352 17260025 7053311 8945911


    Sources:
    TTD

  • LEVOBUNOLOL   ADRB2

    Interaction Score: 2.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6147147 1351412 7928182 11572462 11752352 2892662 2891463


    Sources:
    TdgClinicalTrial TEND

  • PROCATEROL   ADRB2

    Interaction Score: 2.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1682484 1968366 12428391 11752352 1684063 15069780


    Sources:
    TdgClinicalTrial TEND TTD

  • SALMETEROL   ADRB2

    Interaction Score: 2.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Advair/Seretide/Adoair
    Novel drug target Established target
    Trial Name Serevent

    PMIDs:
    1359777 11250877 11752352 10471277 11516429 12897749 24279851 23126384 19932356 19800676 18156033 15500895 11825095


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • PENBUTOLOL   ADRB2

    Interaction Score: 1.93

    Interaction Types & Directionality:
    partial agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8982649 8098761 2189902 11224195 2446632 16716


    Sources:
    TdgClinicalTrial TEND

  • PINDOLOL   ADRB2

    Interaction Score: 1.93

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor partial agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    2903243 1678274 16574446 1666931 11752352 1687398 1979630


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • ARFORMOTEROL   ADRB2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    20406080 14725487 17352511 16022567 17472819 11752352 17594727 18501650


    Sources:
    TdgClinicalTrial TEND TTD

  • CARTEOLOL   ADRB2

    Interaction Score: 1.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    1349493 11752352 15526107 2903243


    Sources:
    DTC TdgClinicalTrial TEND

  • OXPRENOLOL   ADRB2

    Interaction Score: 1.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11311890 7882570 17016423 17139284 9509999


    Sources:
    TdgClinicalTrial TEND

  • ALPRENOLOL   ADRB2

    Interaction Score: 1.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2871880 2439825 2859531 2903243


    Sources:
    DTC TdgClinicalTrial TEND

  • ALBUTEROL   ADRB2

    Interaction Score: 1.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes
    Trial Name albuterol,Ventolin

    PMIDs:
    16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • TIMOLOL   ADRB2

    Interaction Score: 1.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name brimonidine tartrate/timolol maleate,Combigan
    Novel drug target Established target
    Trial Name latanoprost + timolol,Xalcom, Xalacom

    PMIDs:
    10592235 9088585 16205624 9730867 11752352 8103526 8719802


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • BEDORADRINE SULFATE   ADRB2

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MN-221
    Novel drug target Established target
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • AZD3199   ADRB2

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    25709399


    Sources:
    ChemblInteractions TTD

  • OLODATEROL   ADRB2

    Interaction Score: 1.45

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name BI-1744-CL
    Novel drug target Established target

    PMIDs:
    20371707


    Sources:
    TdgClinicalTrial TTD

  • NADOLOL   ADRB2

    Interaction Score: 1.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    2903243 7981009 8574280 1349493 11752352 17622774 10433496


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • METIPRANOLOL   ADRB2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    12967722 2895037 2885244 17016423 17139284 2876128


    Sources:
    TdgClinicalTrial TEND

  • ICI-118551   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • METHACHOLINE   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23384627


    Sources:
    PharmGKB

  • VILANTEROL   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name GW642444
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • CARMOTEROL   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • MILVETEROL   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name milveterol. TD-3327, GSK-159797
    Novel drug target Established target
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ABEDITEROL   ADRB2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name LAS-100977
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • BUPRANOLOL   ADRB2

    Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2903243 12606631


    Sources:
    DTC

  • EPHEDRINE   ADRB2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    26771271 25730298 31613441


    Sources:
    PharmGKB

  • INDACATEROL MALEATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUNITROLOL   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • GSK159802   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METAPROTERENOL SULFATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL531401   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIRBUTEROL ACETATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BAMOSIRAN   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SYL040012
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • VILANTEROL TRIFENATATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALBUTEROL SULFATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUNOLOL   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • BITOLTEROL MESYLATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEVALBUTEROL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PF-00610355   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name PF-00610355
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • INDACATEROL   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Indacaterol
    Novel drug target Established target

    PMIDs:
    16022567


    Sources:
    TdgClinicalTrial PharmGKB TTD

  • CHEMBL604311   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TERBUTALINE SULFATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • CHEMBL579725   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLODATEROL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROTOKYLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DICHLOROISOPROTERENOL   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • ARFORMOTEROL TARTRATE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOETHARINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LABETALOL   ADRB2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    8104240 2907566 6355664 1361547 7684671 19879818 11752352


    Sources:
    TdgClinicalTrial TEND

  • DROXIDOPA   ADRB2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    7969507 9464897 19110970 9666280 18064417


    Sources:
    ChemblInteractions

  • CARVEDILOL   ADRB2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name carvedilol,Coreg
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    21599570 20352314 15861037 12835612 12398570 12360591 14764656 1712335


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND PharmGKB

  • SOTALOL   ADRB2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15060759 19259968 8095397 11815381 2865685 2903243


    Sources:
    DTC

  • ISOPROTERENOL   ADRB2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11586955 14734046 11358333 10784181 19464886 16680159 10722 14656380 15105445 11752352 15151902 14752060 12963495


    Sources:
    DTC TdgClinicalTrial NCI TEND PharmGKB TTD

  • TERTATOLOL   ADRB2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • BUCINDOLOL   ADRB2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name bucindolol hydrochloride,Gencaro
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • MEPINDOLOL   ADRB2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903243


    Sources:
    DTC

  • BATEFENTEROL   ADRB2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PROPRANOLOL   ADRB2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16680159 2903243 11752352 16177222 16082424 17628611 16706406


    Sources:
    DTC TEND PharmGKB

  • RACEPINEPHRINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL111201   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL599896   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOETHARINE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21948594


    Sources:
    TTD

  • ESMOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METIPRANOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIMOLOL MALEATE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEVOBUNOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FENOTEROL HBR   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PENBUTOLOL SULFATE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOETHARINE MESYLATE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • LEVOSALBUTAMOL   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RITODRINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCATEROL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OXPRENOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NEBIVOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LAS190792   ADRB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DESIPRAMINE   ADRB2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7816863 17558518 17417877 8741184 8988485


    Sources:
    TdgClinicalTrial TEND

  • NOREPINEPHRINE   ADRB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2903243 9464897 7969507 11504801 19110970 18064417 9666280 17016423 17139284


    Sources:
    DTC

  • ISOPROTERENOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor beta agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • TIOTROPIUM   ADRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19183167


    Sources:
    PharmGKB

  • REMIFENTANIL   ADRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271


    Sources:
    PharmGKB

  • ROLIPRAM   ADRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19464886


    Sources:
    DTC

  • METOPROLOL   ADRB2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16027735 19637941


    Sources:
    PharmGKB

  • LY377604   ADRB2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYLEPHRINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CARTEOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor beta antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPRANOLOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CLENBUTEROL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   ADRB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    17417877 17622774 11752352 17597612 20837485


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • BENAZEPRIL   ADRB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15554460


    Sources:
    PharmGKB

  • SALMETEROL XINAFOATE   ADRB2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • DIPIVEFRIN HYDROCHLORIDE   ADRB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • SOTALOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOBUTAMINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Beta-2 adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PSEUDOEPHEDRINE   ADRB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    10449190 17016423 17139284


    Sources:
    TEND

  • PHENYLEPHRINE   ADRB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271 25730298


    Sources:
    PharmGKB

  • CARVEDILOL PHOSPHATE   ADRB2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor beta antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VOLANESORSEN SODIUM   ADRB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2557514


    Sources:
    NCI

  • CHEMBL531322   ADRB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL590927   ADRB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1257092   ADRB2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   ADRB2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MEPHENTERMINE SULFATE   ADRB2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EPINEPHRINE BITARTRATE   ADRB2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • FENTANYL   ADRB2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30281924 26771271


    Sources:
    PharmGKB

  • HYDROXYAMPHETAMINE HYDROBROMIDE   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL1256364   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LABETALOL HYDROCHLORIDE   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SPIRONOLACTONE   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543981


    Sources:
    PharmGKB

  • ENALAPRIL   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17178264


    Sources:
    PharmGKB

  • PRILOCAINE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ATENOLOL   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12795776 16027735


    Sources:
    PharmGKB

  • NOREPINEPHRINE BITARTRATE   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL116548   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1465049   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPAFENONE HYDROCHLORIDE   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPOFOL   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271


    Sources:
    PharmGKB

  • 3-O-METHYLQUERCETIN   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SEVOFLURANE   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271


    Sources:
    PharmGKB

  • DIGOXIN   ADRB2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543981


    Sources:
    PharmGKB

  • CLOTRIMAZOLE   ADRB2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DISULFIRAM   ADRB2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RISPERIDONE   ADRB2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000169252

    • Version: 101_38

    Alternate Names:
    ADRB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000169252

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000169252 Ensembl Gene Id
    ADRB2 Display Id
    BETA-2 ADRENERGIC RECEPTOR (BETA-2 ADRENOCEPTOR) (BETA-2 ADRENORECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P07550] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P07550

    • Version: 01-August-2011

    Alternate Names:
    154 Entrez Gene Id
    ADRB2 Gene Symbol
    ENSG00000169252 Ensembl Gene Id

    Gene Info:
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin

    Publications:

  • TdgClinicalTrial: P07550

    • Version: January-2014

    Alternate Names:
    ADRB2 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P07550

    • Version: 11-September-2012

    Alternate Names:
    ADRB2_HUMAN Uniprot Id
    P07550 Uniprot Accession
    ADRB2 Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: ADRB2

    • Version: 18-August-2020

    Alternate Names:
    PA39 PharmGKB ID

    Gene Info:

    Publications:
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
    Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
    Odekon L et al., 2015, The Effect of β2-Adrenoceptor Genotype on Phenylephrine Dose Administered During Spinal Anesthesia for Cesarean Delivery., Anesth Analg

  • TTD: Adrenergic receptor beta-2

    • Version: 2020.06.01

    Alternate Names:
    ADRB2 TTD Gene Abbreviation
    T52522 TTD Target ID

    Gene Info:

    Publications:
    Mantovani G et al., 2013, Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome., Drug Des Devel Ther
    Bjermer L et al., 2015, Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA)., Drug Des Devel Ther

  • NCI: ADRB2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hart et al., 2005, Beta 2 adrenergic receptor polymorphisms in cystic fibrosis., Pediatr. Pulmonol.
    Paetsch et al., 1993, 2-Phenylethylamine-induced changes in catecholamine receptor density: implications for antidepressant drug action., Neurochem. Res.
    Angers et al., 2001, Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells., Life Sci.

  • DTC: ADRB2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Skoumbourdis AP et al., 2009, Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors., Bioorg Med Chem Lett
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

  • ChemblInteractions: ADRB2R

    • Version: chembl_23

    Alternate Names:
    B2AR GENE_SYMBOL
    ADRB2 GENE_SYMBOL
    Beta-2 adrenergic receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000169252

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169252 Gene Symbol
    ADRB2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ADRB2

    • Version: 01-February-2022

    Alternate Names:
    ADRB2R GO Gene Synonym
    B2AR GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: ADRB2

    • Version: 27-Jun-2013

    Alternate Names:
    154 Gene ID
    ADRB2R dGene Synonym
    ADRBR dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • Pharos: ADRB2

    • Version: 01-February-2022

    Alternate Names:
    Beta-2 adrenergic receptor Gene Name
    P07550 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21