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AFP Gene Record

  • Summary
  • Interactions
  • Claims
  • AFP 174 Druggable Genome

    Alternate Names:

    174
    ALPHA FETOPROTEIN
    AFP
    AFPD
    FETA
    HPAFP
    104150
    317
    ENSG00000081051
    OTTHUMG00000130011
    Alpha-fetoprotein
    T10828

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Kobrinsky et al., 2005, Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue., Pediatr Blood Cancer
    Baker et al., 1998, Flavonoids inhibit estrogen binding to rat alpha-fetoprotein., Proc. Soc. Exp. Biol. Med.
    Wollina et al., 1985, [Alpha 1-fetoprotein--a marker of potential PUVA side-effects in psoriasis?]., Z. Hautkr.
    Dror et al., 1994, Aplasia cutis congenita, elevated alpha-fetoprotein, and a distinct amniotic fluid acetylcholinesterase electrophoretic band., Am J Perinatol
    Namiki et al., 1999, Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome., Int. J. Urol.
    Torii et al., 1980, Effect of BCG on hepatocarcinogenesis of the rat induced by 3'-methyl-4-(dimethylamino)azobenzene., Gan
    Imamura et al., 1986, [Successful chemotherapy in undescended testicular and extragonadal germ cell tumors: report of 2 cases]., Gan To Kagaku Ryoho
    Whelan et al., 1992, Successful treatment of a primary endodermal sinus tumor of the liver., Cancer
    Aussel et al., 1987, Effect of alpha-fetoprotein and indomethacin on arachidonic acid metabolism in P388D1 macrophages: role of leukotrienes., Prostaglandins Leukot Med
    Bellizzi et al., 1997, Fetal proteins and chronic treatment with low-dose erythropoietin., J. Lab. Clin. Med.
    Cook et al., 1983, Effect of 5-azacytidine on rat liver alpha-fetoprotein gene expression., Biochem. Biophys. Res. Commun.
    Greiff et al., 1991, [Significant effects on alpha-fetoprotein (AFP) concentration in maternal serum in pregnancy]., Zentralbl Gynakol
  • RUTIN   AFP

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9492341


    Sources:
    NCI

  • BCG VACCINE   AFP

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6155303


    Sources:
    NCI

  • EPOETIN BETA   AFP

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9016855


    Sources:
    NCI

  • BLEOMYCIN   AFP

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10226829


    Sources:
    NCI

  • AZACITIDINE   AFP

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6197072


    Sources:
    NCI

  • ETOPOSIDE   AFP

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2427033 1382827


    Sources:
    NCI

  • INDOMETHACIN   AFP

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2443931


    Sources:
    NCI

  • NICOTINE   AFP

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1711749


    Sources:
    NCI

  • VINCRISTINE   AFP

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15770640


    Sources:
    NCI

  • ASPIRIN   AFP

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7515237


    Sources:
    NCI

  • DOXORUBICIN   AFP

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15770640


    Sources:
    NCI

  • METHOTREXATE   AFP

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2581382


    Sources:
    NCI

  • Ensembl: ENSG00000081051

    • Version: 101_38

    Alternate Names:
    AFP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: AFP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kobrinsky et al., 2005, Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue., Pediatr Blood Cancer
    Greiff et al., 1991, [Significant effects on alpha-fetoprotein (AFP) concentration in maternal serum in pregnancy]., Zentralbl Gynakol
    Sasaki et al., 1987, Distribution of alpha-fetoprotein-producing cells and proliferating cells in human hepatoma cells transplanted into athymic mice., Tumour Biol.

  • HingoraniCasas: ENSG00000081051

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000081051 Gene Symbol
    AFP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Alpha-fetoprotein

    • Version: 2020.06.01

    Alternate Names:
    AFP TTD Gene Abbreviation
    T10828 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21