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AGT Gene Record

  • Summary
  • Interactions
  • Claims
  • AGT 183 Druggable Genome

    Alternate Names:

    183
    ANGIOTENSINOGEN
    AGT
    ANHU
    SERPINA8
    hFLT1
    106150
    333
    ENSG00000135744
    OTTHUMG00000037757
    ANGIOTENSINOGEN PRECURSOR [CONTAINS: ANGIOTENSIN I (ANG I); ANGIOTENSIN II (ANG II); ANGIOTENSIN III (ANG III) (DES-ASP[1]- ANGIOTENSIN II)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P01019]
    EMR2
    30817
    Q9UHX3
    ENSG00000127507
    EMR2_HUMAN
    EGF-LIKE MODULE-CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2
    P01019
    PA42
    ANGT_HUMAN

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000832
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Name GPCR, family 2, secretin-like
    Interpro Short Name GPCR_2_secretin-like
    Uniprot Status Swiss-Prot
    Target Class Other
    Target Subclass Ligand
    Target Subclass Hormone
    Human Readable Name PROTEASE INHIBITOR
    Interpro Acc IPR000215
    Interpro Short Name Serpin_fam
    Interpro Name Serpin family
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    G PROTEIN COUPLED RECEPTOR
    PROTEASE INHIBITOR
    HORMONE ACTIVITY
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Watanabe et al., 2003, Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy., J. Cardiovasc. Pharmacol.
    Toyofyuku et al., 2002, Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention., Atherosclerosis
    Lumbers et al., 2005, Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Kurland L et al., 2004, Angiotensinogen gene polymorphisms: relationship to blood pressure response to antihypertensive treatment. Results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial., Am J Hypertens
    Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens
    Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens
    Yu H et al., 2014, A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors., J Renin Angiotensin Aldosterone Syst
    Su X et al., 2007, Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor., Circulation
    Shiotani A et al., 2011, Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism., Dig Dis Sci
    Barretti et al., 1995, Effects of dietary protein, angiotensin I converting enzyme inhibition and mesangial overload on the progression of adriamycin-induced nephropathy., Braz. J. Med. Biol. Res.
    Niimi et al., 2002, Suppression of endotoxin-induced renal tumor necrosis factor-alpha and interleukin-6 mRNA by renin-angiotensin system inhibitors., Jpn. J. Pharmacol.
    Coezy et al., 1987, Effect of mestranol on cell proliferation and angiotensinogen production in HepG2 cells: relation with the cell cycle and action of tamoxifen., Endocrinology
  • QUINAPRIL   AGT

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12693379 11849656


    Sources:
    NCI PharmGKB

  • CYT006-ANGQB   AGT

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CYT006-AngQb
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • IMIDAPRIL   AGT

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25143324


    Sources:
    PharmGKB

  • BENAZEPRIL   AGT

    Interaction Score: 1.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25143324 17261659


    Sources:
    PharmGKB

  • IRBESARTAN   AGT

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15614026 14700505 11593098


    Sources:
    PharmGKB

  • MESTRANOL   AGT

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3023023


    Sources:
    NCI

  • CHLORTHALIDONE   AGT

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LISINOPRIL   AGT

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ADRIAMYCIN   AGT

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7581027


    Sources:
    NCI

  • ENALAPRIL   AGT

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11928713


    Sources:
    NCI

  • ATENOLOL   AGT

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14700505 11593098


    Sources:
    PharmGKB

  • AMLODIPINE   AGT

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HYDROCORTISONE   AGT

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15576665


    Sources:
    NCI

  • ASPIRIN   AGT

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20824505


    Sources:
    PharmGKB

  • Ensembl: ENSG00000135744

    • Version: 101_38

    Alternate Names:
    AGT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000135744

    • Version: 26-July-2011

    Alternate Names:
    ANGIOTENSINOGEN PRECURSOR [CONTAINS: ANGIOTENSIN I (ANG I); ANGIOTENSIN II (ANG II); ANGIOTENSIN III (ANG III) (DES-ASP[1]- ANGIOTENSIN II)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P01019] Description
    ENSG00000135744 Ensembl Gene Id
    AGT Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q9UHX3

    • Version: 11-September-2012

    Alternate Names:
    EMR2_HUMAN Uniprot Id
    EGF-LIKE MODULE-CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 Uniprot Protein Name
    30817 Entrez Gene Id

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000832
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P01019

    • Version: January-2014

    Alternate Names:
    AGT Gene Symbol

    Gene Info:
    Target Class Other
    Target Subclass Ligand
    Target Subclass Hormone

    Publications:

  • HopkinsGroom: P01019

    • Version: 11-September-2012

    Alternate Names:
    183 Entrez Gene Id
    ANGIOTENSINOGEN Uniprot Protein Name
    ENSG00000135744 Ensembl Gene Id

    Gene Info:
    Human Readable Name PROTEASE INHIBITOR
    Interpro Acc IPR000215
    Interpro Type Family

    Gene Categories:
    PROTEASE INHIBITOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: AGT

    • Version: 18-August-2020

    Alternate Names:
    PA42 PharmGKB ID

    Gene Info:

    Publications:
    Bis JC et al., 2003, Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients., Am J Hypertens
    St Germaine CG et al., 2010, Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs., Am J Cardiol
    Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens

  • NCI: AGT

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Takase et al., 2005, NF-kappaB-dependent increase in intrarenal angiotensin II induced by proteinuria., Kidney Int.
    Yoshiji et al., 2004, Angiotensin-I converting enzyme inhibitors as potential anti-angiogenic agents for cancer therapy., Curr Cancer Drug Targets
    Petrescu et al., 2001, Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity., J Renin Angiotensin Aldosterone Syst

  • HingoraniCasas: ENSG00000135744

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135744 Gene Symbol
    AGT Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: AGT

    • Version: 01-February-2022

    Alternate Names:
    SERPINA8 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR, HORMONE ACTIVITY

    Publications:

  • dGene: AGT

    • Version: 27-Jun-2013

    Alternate Names:
    183 Gene ID
    ANHU dGene Synonym
    SERPINA8 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • Pharos: AGT

    • Version: 01-February-2022

    Alternate Names:
    Angiotensinogen Gene Name
    P01019 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21