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AGTR2 Gene Record

  • Summary
  • Interactions
  • Claims
  • AGTR2 186 Druggable Genome

    Alternate Names:

    186
    ANGIOTENSIN II RECEPTOR TYPE 2
    AGTR2
    AT2
    ATGR2
    MRX88
    300034
    338
    ENSG00000180772
    OTTHUMG00000022243
    P50052
    TYPE-2 ANGIOTENSIN II RECEPTOR
    AGTR2_HUMAN
    TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052]
    Angiotensin II receptor type-2
    T09909

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Target Class receptor
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Wallinder C et al., 2014, Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands., ACS Med Chem Lett
    Geng et al., 2006, Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction., Int. J. Cardiol.
    Ghosh et al., 2002, The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury., Am. J. Med. Sci.
    Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.
  • OLODANRIGAN   AGTR2

    Interaction Score: 10.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AZD-4017   AGTR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22691057


    Sources:
    DTC

  • CHEMBL157946   AGTR2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25699147


    Sources:
    DTC

  • SARALASIN   AGTR2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PUROMYCIN   AGTR2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495295


    Sources:
    NCI

  • ROSIGLITAZONE   AGTR2

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16891009


    Sources:
    NCI

  • Ensembl: ENSG00000180772

    • Version: 101_38

    Alternate Names:
    AGTR2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P50052

    • Version: 11-September-2012

    Alternate Names:
    186 Entrez Gene Id
    AGTR2 Uniprot Gene Name
    P50052 Uniprot Accession

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P50052

    • Version: January-2014

    Alternate Names:
    AGTR2 Gene Symbol

    Gene Info:
    Target Class receptor
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000180772

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000180772 Ensembl Gene Id
    TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052] Description
    AGTR2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: AGTR2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Geng et al., 2006, Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction., Int. J. Cardiol.
    Li et al., 1999, Transcriptional and translational regulation of angiotensin II type 2 receptor by angiotensin II and growth factors., Endocrinology
    Ghosh et al., 2002, The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury., Am. J. Med. Sci.

  • DTC: AGTR2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wallinder C et al., 2014, Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands., ACS Med Chem Lett
    Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.

  • HingoraniCasas: ENSG00000180772

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000180772 Gene Symbol
    AGTR2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: AGTR2

    • Version: 27-Jun-2013

    Alternate Names:
    186 Gene ID
    AT2 dGene Synonym
    ATGR2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Angiotensin II receptor type-2

    • Version: 2020.06.01

    Alternate Names:
    AGTR2 TTD Gene Abbreviation
    T09909 TTD Target ID

    Gene Info:

    Publications:

  • GO: AGTR2

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21