DGIdb - AGTR2 Gene Record

AGTR2 186 Druggable Genome

Alternate Names:

186
ANGIOTENSIN II RECEPTOR TYPE 2
AGTR2
AT2
ATGR2
MRX88
300034
338
ENSG00000180772
OTTHUMG00000022243
P50052
TYPE-2 ANGIOTENSIN II RECEPTOR
AGTR2_HUMAN
TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052]
Angiotensin II receptor type-2
T09909

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000276
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Target Class	receptor
Target Subclass	GPCR
Target Subclass	Rhodopsin
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Wallinder C et al., 2014, Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands., ACS Med Chem Lett
Geng et al., 2006, Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction., Int. J. Cardiol.
Ghosh et al., 2002, The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury., Am. J. Med. Sci.
Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.

OLODANRIGAN AGTR2

Interaction Score: 10.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
AZD-4017 AGTR2

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22691057

Sources:
DTC
CHEMBL157946 AGTR2

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25699147

Sources:
DTC
SARALASIN AGTR2

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PUROMYCIN AGTR2

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495295

Sources:
NCI
ROSIGLITAZONE AGTR2

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16891009

Sources:
NCI

Ensembl: ENSG00000180772
- Version: 101_38
Alternate Names:

AGTR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P50052
- Version: 11-September-2012
Alternate Names:

186 Entrez Gene Id

AGTR2 Uniprot Gene Name

P50052 Uniprot Accession

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name GPCR, rhodopsin-like, 7TM

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P50052
- Version: January-2014
Alternate Names:

AGTR2 Gene Symbol

Gene Info:

Target Class receptor

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000180772
- Version: 26-July-2011
Alternate Names:

ENSG00000180772 Ensembl Gene Id

TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052] Description

AGTR2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: AGTR2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Geng et al., 2006, Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction., Int. J. Cardiol.

Li et al., 1999, Transcriptional and translational regulation of angiotensin II type 2 receptor by angiotensin II and growth factors., Endocrinology

Ghosh et al., 2002, The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury., Am. J. Med. Sci.

DTC: AGTR2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wallinder C et al., 2014, Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands., ACS Med Chem Lett

Scott et al., 2012, Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)., J. Med. Chem.

HingoraniCasas: ENSG00000180772
- Version: 31-May-2017
Alternate Names:

ENSG00000180772 Gene Symbol

AGTR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: AGTR2
- Version: 27-Jun-2013
Alternate Names:

186 Gene ID

AT2 dGene Synonym

ATGR2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Angiotensin II receptor type-2
- Version: 2020.06.01
Alternate Names:

AGTR2 TTD Gene Abbreviation

T09909 TTD Target ID

Gene Info:

Publications:
GO: AGTR2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

186	Entrez Gene Id
AGTR2	Uniprot Gene Name
P50052	Uniprot Accession

ENSG00000180772	Ensembl Gene Id
TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052]	Description
AGTR2	Display Id

AGTR2 Gene Record

AGTR2 186 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

OLODANRIGAN AGTR2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

AZD-4017 AGTR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22691057

Sources: DTC

CHEMBL157946 AGTR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25699147

Sources: DTC

SARALASIN AGTR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

PUROMYCIN AGTR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495295

Sources: NCI

ROSIGLITAZONE AGTR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16891009

Sources: NCI

Ensembl: ENSG00000180772

Alternate Names: AGTR2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P50052

Alternate Names: 186 Entrez Gene Id AGTR2 Uniprot Gene Name P50052 Uniprot Accession

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Name GPCR, rhodopsin-like, 7TM Uniprot Evidence 1: Evidence at protein level

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P50052

Alternate Names: AGTR2 Gene Symbol

Gene Info: Target Class receptor Target Subclass GPCR Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000180772

Alternate Names: ENSG00000180772 Ensembl Gene Id TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052] Description AGTR2 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: AGTR2

Alternate Names:

Gene Info:

DTC: AGTR2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000180772

Alternate Names: ENSG00000180772 Gene Symbol AGTR2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

dGene: AGTR2

Alternate Names: 186 Gene ID AT2 dGene Synonym ATGR2 dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

TTD: Angiotensin II receptor type-2

Alternate Names: AGTR2 TTD Gene Abbreviation T09909 TTD Target ID

Gene Info:

Publications:

GO: AGTR2

Alternate Names:

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22691057

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25699147

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12495295

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16891009

Sources:
NCI

Alternate Names:

AGTR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

186 Entrez Gene Id

AGTR2 Uniprot Gene Name

P50052 Uniprot Accession

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name GPCR, rhodopsin-like, 7TM

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

AGTR2 Gene Symbol

Gene Info:

Target Class receptor

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

ENSG00000180772 Ensembl Gene Id

TYPE-2 ANGIOTENSIN II RECEPTOR (AT2). [SOURCE:UNIPROT/SWISSPROT;ACC:P50052] Description

AGTR2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000180772 Gene Symbol

AGTR2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

186 Gene ID

AT2 dGene Synonym

ATGR2 dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

AGTR2 TTD Gene Abbreviation

T09909 TTD Target ID

Gene Categories:

G PROTEIN COUPLED RECEPTOR