• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ALDH1A2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALDH1A2 8854 Druggable Genome

    Alternate Names:

    8854
    ALDEHYDE DEHYDROGENASE 1 FAMILY MEMBER A2
    ALDH1A2
    RALDH(II)
    RALDH2
    RALDH2-T
    603687
    15472
    ENSG00000128918
    OTTHUMG00000132624
    O94788
    RETINAL DEHYDROGENASE 2
    AL1A2_HUMAN
    PA24693
    RETINAL DEHYDROGENASE 2 (EC 1.2.1.36) (RALDH2) (RALDH 2) (RALDH(II)) (RETINALDEHYDE-SPECIFIC DEHYDROGENASE TYPE 2) (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94788]

    Gene Info:

    Interpro Name Aldehyde dehydrogenase domain
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR015590
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Aldehyde_DH_dom
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Bhat et al., 1998, Differentiation-dependent regulation of retinal dehydrogenase gene expression in the trachea., Biochem. Cell Biol.
    Magvanjav O et al., 2017, Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials., J Am Heart Assoc
  • RETINOL   ALDH1A2

    Interaction Score: 3.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9666306


    Sources:
    NCI

  • ATENOLOL   ALDH1A2

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29097388


    Sources:
    PharmGKB

  • HYDROCHLOROTHIAZIDE   ALDH1A2

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29097388


    Sources:
    PharmGKB

  • Ensembl: ENSG00000128918

    • Version: 101_38

    Alternate Names:
    ALDH1A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O94788

    • Version: 11-September-2012

    Alternate Names:
    O94788 Uniprot Accession
    ENSG00000128918 Ensembl Gene Id
    ALDH1A2 Uniprot Gene Name

    Gene Info:
    Interpro Name Aldehyde dehydrogenase domain
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000128918

    • Version: 26-July-2011

    Alternate Names:
    RETINAL DEHYDROGENASE 2 (EC 1.2.1.36) (RALDH2) (RALDH 2) (RALDH(II)) (RETINALDEHYDE-SPECIFIC DEHYDROGENASE TYPE 2) (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94788] Description
    ALDH1A2 Display Id
    ENSG00000128918 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ALDH1A2

    • Version: 18-August-2020

    Alternate Names:
    PA24693 PharmGKB ID

    Gene Info:

    Publications:
    Magvanjav O et al., 2017, Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials., J Am Heart Assoc

  • NCI: ALDH1A2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Duester, 2001, Genetic dissection of retinoid dehydrogenases., Chem. Biol. Interact.
    Molotkova et al., 2005, Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation., Mech. Dev.
    Mic et al., 2003, Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2., Dev. Biol.

  • HingoraniCasas: ENSG00000128918

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000128918 Gene Symbol
    ALDH1A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: ALDH1A2

    • Version: 01-February-2022

    Alternate Names:
    Retinal dehydrogenase 2 Gene Name
    O94788 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21