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ALDH2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALDH2 217 Druggable GenomeClinically Actionable

    Alternate Names:

    217
    ALDEHYDE DEHYDROGENASE 2 FAMILY (MITOCHONDRIAL)
    ALDH2
    ALDH-E2
    ALDHI
    ALDM
    100650
    404
    ENSG00000111275
    OTTHUMG00000169603
    P05091
    ALDH2_HUMAN
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.3) (ALDH CLASS 2) (ALDHI) (ALDH-E2). [SOURCE:UNIPROT/SWISSPROT;ACC:P05091]
    ALDH class 2
    aldehyde dehydrogenase 2 family member
    PA24696
    Mitochondrial aldehyde dehydrogenase
    T44282

    Gene Info:

    Target Subclass 1.2.1.3
    Target Main Class Enzymes
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Aldehyde_DH_dom
    Interpro Name Aldehyde dehydrogenase domain
    Interpro Acc IPR015590
    Target Class Enzymes
    Target Subclass EC:1.2.1.3
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Mackenzie et al., 2005, Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans., Arterioscler. Thromb. Vasc. Biol.
    Ho et al., 2007, Refractive hypotension in a patient with disulfiram-ethanol reaction., Am. J. Med. Sci.
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Wang TY et al., 2012, The aldehyde dehydrogenase 2 gene is associated with heroin dependence., Drug Alcohol Depend
    Matsumoto et al., 1996, Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats., Alcohol. Clin. Exp. Res.
    Nishizawa D et al., 2006, Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population., Neuropsychobiology
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
  • ACETALDEHYDE   ALDH2

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31002879


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   ALDH2

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21723677


    Sources:
    PharmGKB

  • DISULFIRAM   ALDH2

    Interaction Score: 1.98

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Aldehyde dehydrogenase inhibitor
    Trial Name -

    PMIDs:
    16051882 17220694


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ALCOHOL   ALDH2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8986223 31002879 16679777 15902904


    Sources:
    NCI PharmGKB

  • Ensembl: ENSG00000111275

    • Version: 101_38

    Alternate Names:
    ALDH2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P05091

    • Version: 01-August-2011

    Alternate Names:
    217 Entrez Gene Id
    P05091 Uniprot Accession
    ALDH2_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 1.2.1.3
    Target Main Class Enzymes

    Publications:

  • TdgClinicalTrial: P05091

    • Version: January-2014

    Alternate Names:
    ALDH2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.2.1.3

    Publications:

  • RussLampel: ENSG00000111275

    • Version: 26-July-2011

    Alternate Names:
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.3) (ALDH CLASS 2) (ALDHI) (ALDH-E2). [SOURCE:UNIPROT/SWISSPROT;ACC:P05091] Description
    ALDH2 Display Id
    ENSG00000111275 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P05091

    • Version: 11-September-2012

    Alternate Names:
    ALDH2 Uniprot Gene Name
    ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL Uniprot Protein Name
    P05091 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ALDH2

    • Version: 18-August-2020

    Alternate Names:
    PA24696 PharmGKB ID

    Gene Info:

    Publications:
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
    Nishizawa D et al., 2006, Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population., Neuropsychobiology

  • NCI: ALDH2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Matsumoto et al., 1996, Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats., Alcohol. Clin. Exp. Res.

  • ChemblInteractions: ALDM

    • Version: chembl_23

    Alternate Names:
    ALDM GENE_SYMBOL
    ALDH2 GENE_SYMBOL
    Aldehyde dehydrogenase, mitochondrial UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000111275

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111275 Gene Symbol
    ALDH2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Mitochondrial aldehyde dehydrogenase

    • Version: 2020.06.01

    Alternate Names:
    ALDH2 TTD Gene Abbreviation
    T44282 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ALDH2

    • Version: 01-February-2022

    Alternate Names:
    Aldehyde dehydrogenase, mitochondrial Gene Name
    P05091 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • CarisMolecularIntelligence: ALDH2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21