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ALDH5A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALDH5A1 7915 Druggable Genome

    Alternate Names:

    7915
    ALDEHYDE DEHYDROGENASE 5 FAMILY MEMBER A1
    ALDH5A1
    SSADH
    SSDH
    610045
    408
    ENSG00000112294
    OTTHUMG00000014356
    P51649
    NAD(+)-DEPENDENT SUCCINIC SEMIALDEHYDE DEHYDROGENASE
    Succinate-semialdehyde dehydrogenase, mitochondrial
    Aldehyde dehydrogenase family 5 member A1
    SUCCINATE SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.24) (NAD(+)-DEPENDENT SUCCINIC SEMIALDEHYDE DEHYDROGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P51649]
    SSDH_HUMAN
    PA24702
    Succinate-semialdehyde dehydrogenase
    T13259

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Aldehyde_DH_dom
    Interpro Name Aldehyde dehydrogenase domain
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR015590
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Oda, 1968, [Experimental study on renal succinic dehydrogenase. 2. Age differences in renal succinic dehydrogenase in rats administered diuretics]., Nihon Shonika Gakkai Zasshi
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Fonseca F et al., 2014, ALDH5A1 variability in opioid dependent patients could influence response to methadone treatment., Eur Neuropsychopharmacol
    Kehler L et al., 2000, Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid., Bioorg Med Chem Lett
  • CHLORMERODRIN   ALDH5A1

    Interaction Score: 30.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    5692397 17016423 17139284 11752352


    Sources:
    TTD

  • DIVALPROEX SODIUM   ALDH5A1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VALPROATE SODIUM   ALDH5A1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VALPROIC ACID   ALDH5A1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Succinate semialdehyde dehydrogenase inhibitor
    Direct Interaction yes

    PMIDs:
    11086726


    Sources:
    DTC ChemblInteractions

  • METHADONE   ALDH5A1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24230997


    Sources:
    PharmGKB

  • Ensembl: ENSG00000112294

    • Version: 101_38

    Alternate Names:
    ALDH5A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P51649

    • Version: 11-September-2012

    Alternate Names:
    7915 Entrez Gene Id
    SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL Uniprot Protein Name
    ENSG00000112294 Ensembl Gene Id

    Gene Info:
    Interpro Short Name Aldehyde_DH_dom
    Interpro Name Aldehyde dehydrogenase domain
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000112294

    • Version: 26-July-2011

    Alternate Names:
    ALDH5A1 Display Id
    SUCCINATE SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.2.1.24) (NAD(+)-DEPENDENT SUCCINIC SEMIALDEHYDE DEHYDROGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P51649] Description
    ENSG00000112294 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ALDH5A1

    • Version: 18-August-2020

    Alternate Names:
    PA24702 PharmGKB ID

    Gene Info:

    Publications:
    Fonseca F et al., 2014, ALDH5A1 variability in opioid dependent patients could influence response to methadone treatment., Eur Neuropsychopharmacol
    Ghodke-Puranik Y et al., 2013, Valproic acid pathway: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DTC: ALDH5A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kehler L et al., 2000, Novel phosphinic and phosphonic acid analogues of the anticonvulsant valproic acid., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000112294

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000112294 Gene Symbol
    ALDH5A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: SSADH

    • Version: chembl_23

    Alternate Names:
    SSADH GENE_SYMBOL
    ALDH5A1 GENE_SYMBOL
    Succinate-semialdehyde dehydrogenase, mitochondrial UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: ALDH5A1

    • Version: 19.3

    Alternate Names:
    ENSG00000112294 Ensembl Gene ID
    SSADH Human Protein Atlas Gene Synonym
    SSDH Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Succinate-semialdehyde dehydrogenase

    • Version: 2020.06.01

    Alternate Names:
    ALDH5A1 TTD Gene Abbreviation
    T13259 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ALDH5A1

    • Version: 01-February-2022

    Alternate Names:
    Succinate-semialdehyde dehydrogenase, mitochondrial Gene Name
    P51649 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21