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ALOX12 Gene Record

  • Summary
  • Interactions
  • Claims
  • ALOX12 239 Druggable Genome

    Alternate Names:

    239
    ARACHIDONATE 12-LIPOXYGENASE, 12S TYPE
    ALOX12
    12-LOX
    12S-LOX
    LOG12
    152391
    429
    ENSG00000108839
    OTTHUMG00000102088
    LOX12_HUMAN
    P18054
    ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
    ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054]
    PA45

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000907
    Interpro Name Lipoxygenase
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name LipOase
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics
    Robinson SJ et al., 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes., J Nat Prod
  • CHEMBL1164975   ALOX12

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19848434


    Sources:
    DTC

  • CHEMBL528045   ALOX12

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIPYRONE SODIUM   ALOX12

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1448292   ALOX12

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • N,N'-DIPHENYL-P-PHENYLENEDIAMINE   ALOX12

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETHOPROPAZINE HYDROCHLORIDE   ALOX12

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL580727   ALOX12

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CADMIUM DICHLORIDE   ALOX12

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL261557   ALOX12

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 5,7-DIHYDROXYISOFLAVONE   ALOX12

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL154580   ALOX12

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FISETIN   ALOX12

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EMBELIN   ALOX12

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENOTHIAZINE   ALOX12

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TYRPHOSTIN 47   ALOX12

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL68534   ALOX12

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MERCURIC CHLORIDE   ALOX12

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SANGUINARIUM   ALOX12

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL592124   ALOX12

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CELECOXIB   ALOX12

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23778325


    Sources:
    PharmGKB

  • EBSELEN   ALOX12

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000108839

    • Version: 101_38

    Alternate Names:
    ALOX12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P18054

    • Version: 11-September-2012

    Alternate Names:
    LOX12_HUMAN Uniprot Id
    239 Entrez Gene Id
    ALOX12 Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000907
    Interpro Name Lipoxygenase

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000108839

    • Version: 26-July-2011

    Alternate Names:
    ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054] Description
    ALOX12 Display Id
    ENSG00000108839 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ALOX12

    • Version: 18-August-2020

    Alternate Names:
    PA45 PharmGKB ID

    Gene Info:

    Publications:
    Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics

  • DTC: ALOX12

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Robinson SJ et al., 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes., J Nat Prod

  • HingoraniCasas: ENSG00000108839

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000108839 Gene Symbol
    ALOX12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ALOX12

    • Version: 19.3

    Alternate Names:
    ENSG00000108839 Ensembl Gene ID
    12S-LOX Human Protein Atlas Gene Synonym
    Arachidonate 12-lipoxygenase, 12S type Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: ALOX12

    • Version: 01-February-2022

    Alternate Names:
    Arachidonate 12-lipoxygenase, 12S-type Gene Name
    P18054 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21