DGIdb - ALOX12 Gene Record

ALOX12 239 Druggable Genome

Alternate Names:

239
ARACHIDONATE 12-LIPOXYGENASE, 12S TYPE
ALOX12
12-LOX
12S-LOX
LOG12
152391
429
ENSG00000108839
OTTHUMG00000102088
LOX12_HUMAN
P18054
ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE
1387
ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054]
PA45

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000907
Interpro Name	Lipoxygenase
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	LipOase
Interpro Type	Family
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Lipoxygenases
GuideToPharmacology Gene Category ID	271

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics
Robinson SJ et al., 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes., J Nat Prod

CHEMBL1164975 ALOX12

Interaction Score: 6.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19848434

Sources:
DTC
CHEMBL528045 ALOX12

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRONE SODIUM ALOX12

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1448292 ALOX12

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
N,N'-DIPHENYL-P-PHENYLENEDIAMINE ALOX12

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ETHOPROPAZINE HYDROCHLORIDE ALOX12

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580727 ALOX12

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CADMIUM DICHLORIDE ALOX12

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL261557 ALOX12

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
5,7-DIHYDROXYISOFLAVONE ALOX12

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL154580 ALOX12

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FISETIN ALOX12

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMBELIN ALOX12

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENOTHIAZINE ALOX12

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TYRPHOSTIN 47 ALOX12

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL68534 ALOX12

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MERCURIC CHLORIDE ALOX12

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SANGUINARIUM ALOX12

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL592124 ALOX12

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB ALOX12

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23778325

Sources:
PharmGKB
EBSELEN ALOX12

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000108839
- Version: 101_38
Alternate Names:

ALOX12 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P18054
- Version: 11-September-2012
Alternate Names:

LOX12_HUMAN Uniprot Id

239 Entrez Gene Id

ALOX12 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000907

Interpro Name Lipoxygenase

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000108839

Version: 26-July-2011

Alternate Names:

ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054] Description

ALOX12 Display Id

ENSG00000108839 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 239
- Version: 29-September-2020
Alternate Names:

429 HUGO Gene ID

429 HUGO Gene Symbol

arachidonate 12-lipoxygenase, 12S type HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Lipoxygenases

GuideToPharmacology Gene Category ID 271

Gene Categories:

ENZYME

Publications:
PharmGKB: ALOX12
- Version: 18-August-2020
Alternate Names:

PA45 PharmGKB ID

Gene Info:

Publications:

Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics
DTC: ALOX12
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Robinson SJ et al., 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes., J Nat Prod
HingoraniCasas: ENSG00000108839
- Version: 31-May-2017
Alternate Names:

ENSG00000108839 Gene Symbol

ALOX12 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: ALOX12
- Version: 19.3
Alternate Names:

ENSG00000108839 Ensembl Gene ID

12S-LOX Human Protein Atlas Gene Synonym

Arachidonate 12-lipoxygenase, 12S type Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: ALOX12
- Version: 01-May-2021
Alternate Names:

Arachidonate 12-lipoxygenase, 12S-type Gene Name

P18054 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

LOX12_HUMAN	Uniprot Id
239	Entrez Gene Id
ALOX12	Uniprot Gene Name

ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054]	Description
ALOX12	Display Id
ENSG00000108839	Ensembl Gene Id

429	HUGO Gene ID
429	HUGO Gene Symbol
arachidonate 12-lipoxygenase, 12S type	HUGO Gene Name

Arachidonate 12-lipoxygenase, 12S-type	Gene Name
P18054	UniProt ID

ALOX12 Gene Record

ALOX12 239 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19848434

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
19848434

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23778325

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ALOX12 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

LOX12_HUMAN Uniprot Id

239 Entrez Gene Id

ALOX12 Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000907

Interpro Name Lipoxygenase

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (EC 1.13.11.31) (12-LOX) (PLATELET-TYPE LIPOXYGENASE 12). [SOURCE:UNIPROT/SWISSPROT;ACC:P18054] Description

ALOX12 Display Id

ENSG00000108839 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

429 HUGO Gene ID

429 HUGO Gene Symbol

arachidonate 12-lipoxygenase, 12S type HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Lipoxygenases

GuideToPharmacology Gene Category ID 271

Gene Categories:

ENZYME

Alternate Names:

PA45 PharmGKB ID

Publications:

Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics

Publications:

Robinson SJ et al., 2009, Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes., J Nat Prod

Alternate Names:

ENSG00000108839 Gene Symbol

ALOX12 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000108839 Ensembl Gene ID

12S-LOX Human Protein Atlas Gene Synonym

Arachidonate 12-lipoxygenase, 12S type Human Protein Atlas Gene Description