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APOA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • APOA1 335 Druggable Genome

    Alternate Names:

    335
    APOLIPOPROTEIN A1
    APOA1
    apo(a)
    107680
    600
    ENSG00000118137
    OTTHUMG00000046112
    P02647
    PA49
    apolipoprotein A-I
    T56545
    HPALP2

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Apolipoprotein A1/A4/E family
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tang et al., 1991, In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs at the translational level in inbred strains of mice., Biochem. Biophys. Res. Commun.
    Sankatsing et al., 2007, Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy., J. Infect. Dis.
    Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature
    Aslibekyan S et al., 2012, Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate., PLoS One
    Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics
    Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology
    Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis
    Avdulov et al., 2000, Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol., Biochemistry
  • CHEMBL247920   APOA1

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17554340


    Sources:
    DTC

  • APABETALONE   APOA1

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name RVX-208

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • GLUCAGON   APOA1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3130065


    Sources:
    NCI

  • FUROSEMIDE   APOA1

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1446618


    Sources:
    NCI

  • FENOFIBRATE   APOA1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23119086 19207029


    Sources:
    PharmGKB

  • LAMIVUDINE   APOA1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17538878


    Sources:
    NCI

  • TESTOSTERONE   APOA1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1764091


    Sources:
    NCI

  • ALCOHOL   APOA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10956052


    Sources:
    NCI

  • Ensembl: ENSG00000118137

    • Version: 101_38

    Alternate Names:
    APOA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P02647

    • Version: January-2014

    Alternate Names:
    APOA1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Apolipoprotein A1/A4/E family

    Publications:

  • PharmGKB: APOA1

    • Version: 18-August-2020

    Alternate Names:
    PA49 PharmGKB ID

    Gene Info:

    Publications:
    Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics
    Aslibekyan S et al., 2012, Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate., PLoS One

  • NCI: APOA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sankatsing et al., 2007, Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy., J. Infect. Dis.
    Costa-Scharplatz et al., 2008, Cost-effectiveness analysis of rosuvastatin versus atorvastatin, simvastatin, and pravastatin from a Canadian health system perspective., Clin Ther
    Kojima et al., 2001, Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein., Biochim. Biophys. Acta

  • DTC: APOA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature

  • HingoraniCasas: ENSG00000118137

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000118137 Gene Symbol
    APOA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Apolipoprotein A-I

    • Version: 2020.06.01

    Alternate Names:
    APOA1 TTD Gene Abbreviation
    T56545 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: APOA1

    • Version: 01-February-2022

    Alternate Names:
    Apolipoprotein A-I Gene Name
    P02647 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: APOA1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21