DGIdb - APOA1 Gene Record

APOA1 335 Druggable Genome

Alternate Names:

335
APOLIPOPROTEIN A1
APOA1
apo(a)
107680
600
ENSG00000118137
OTTHUMG00000046112
P02647
PA49
apolipoprotein A-I
T56545
HPALP2

Gene Info:

Target Class	Miscellaneous
Target Subclass	Apolipoprotein A1/A4/E family
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME
ENZYME

Publications:

Tang et al., 1991, In vivo regulation of apolipoprotein A-I gene expression by estradiol and testosterone occurs at the translational level in inbred strains of mice., Biochem. Biophys. Res. Commun.
Sankatsing et al., 2007, Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy., J. Infect. Dis.
Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature
Aslibekyan S et al., 2012, Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate., PLoS One
Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics
Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology
Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis
Avdulov et al., 2000, Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol., Biochemistry

CHEMBL247920 APOA1

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17554340

Sources:
DTC
APABETALONE APOA1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name RVX-208

PMIDs:
None found

Sources:
TdgClinicalTrial
GLUCAGON APOA1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3130065

Sources:
NCI
FUROSEMIDE APOA1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1446618

Sources:
NCI
FENOFIBRATE APOA1

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23119086 19207029

Sources:
PharmGKB
LAMIVUDINE APOA1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17538878

Sources:
NCI
TESTOSTERONE APOA1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1764091

Sources:
NCI
ALCOHOL APOA1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10956052

Sources:
NCI

Ensembl: ENSG00000118137
- Version: 101_38
Alternate Names:

APOA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P02647
- Version: January-2014
Alternate Names:

APOA1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Apolipoprotein A1/A4/E family

Publications:

PharmGKB: APOA1

Version: 18-August-2020

Alternate Names:

PA49 PharmGKB ID

Gene Info:

Publications:

Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics

Aslibekyan S et al., 2012, Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate., PLoS One

NCI: APOA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Sankatsing et al., 2007, Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy., J. Infect. Dis.

Costa-Scharplatz et al., 2008, Cost-effectiveness analysis of rosuvastatin versus atorvastatin, simvastatin, and pravastatin from a Canadian health system perspective., Clin Ther

Kojima et al., 2001, Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein., Biochim. Biophys. Acta

DTC: APOA1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature
HingoraniCasas: ENSG00000118137
- Version: 31-May-2017
Alternate Names:

ENSG00000118137 Gene Symbol

APOA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Apolipoprotein A-I
- Version: 2020.06.01
Alternate Names:

APOA1 TTD Gene Abbreviation

T56545 TTD Target ID

Gene Info:

Publications:
Pharos: APOA1
- Version: 01-February-2022
Alternate Names:

Apolipoprotein A-I Gene Name

P02647 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: APOA1
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Novel drug target	Novel Target
Trial Name	RVX-208

APOA1 Gene Record

APOA1 335 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17554340

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name RVX-208

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3130065

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1446618

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23119086 19207029

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17538878

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1764091

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10956052

Sources: NCI

Ensembl: ENSG00000118137

Alternate Names: APOA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P02647

Alternate Names: APOA1 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Apolipoprotein A1/A4/E family

Publications:

PharmGKB: APOA1

Alternate Names: PA49 PharmGKB ID

Gene Info:

NCI: APOA1

Alternate Names:

Gene Info:

DTC: APOA1

Alternate Names:

Gene Info:

Publications: Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature

HingoraniCasas: ENSG00000118137

Alternate Names: ENSG00000118137 Gene Symbol APOA1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Apolipoprotein A-I

Alternate Names: APOA1 TTD Gene Abbreviation T56545 TTD Target ID

Gene Info:

Publications:

Pharos: APOA1

Alternate Names: Apolipoprotein A-I Gene Name P02647 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

GO: APOA1

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17554340

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name RVX-208

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
3130065

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1446618

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23119086 19207029

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17538878

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1764091

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10956052

Sources:
NCI

Alternate Names:

APOA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

APOA1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Apolipoprotein A1/A4/E family

Alternate Names:

PA49 PharmGKB ID

Publications:

Furuhashi M et al., 2007, Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2., Nature

Alternate Names:

ENSG00000118137 Gene Symbol

APOA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

APOA1 TTD Gene Abbreviation

T56545 TTD Target ID

Alternate Names:

Apolipoprotein A-I Gene Name

P02647 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CELL SURFACE