DGIdb - APOB Gene Record

APOB 338 Druggable Genome

Alternate Names:

338
APOLIPOPROTEIN B
APOB
FLDB
LDLCQ4
apoB-100
apoB-48
107730
603
ENSG00000084674
OTTHUMG00000090785
APOLIPOPROTEIN B-100 PRECURSOR (APO B-100) [CONTAINS: APOLIPOPROTEIN B-48 (APO B-48)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04114]
APOLIPOPROTEIN B-100
P04114
APOB_HUMAN
PA50
APOLIPOPROTEIN B-48
T07533
BE0009908

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Miscellaneous
Target Subclass	Enzyme cofactor
Interpro Acc	IPR001747
Interpro Short Name	Lipid_transpt_N
Interpro Name	Lipid transport protein, N-terminal
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Lau et al., 1995, Ethanol modulates apolipoprotein B mRNA editing in the rat., J. Lipid Res.
Pau et al., Inhibition of hydroxymethylglutaryl coenzyme A reductase activity does not affect the secretion rate of apolipoproteins B and AI by CaCo-2 cells., Biochem. Cell Biol.
Arad et al., 1990, Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production., J. Lipid Res.
Arad et al., 1992, Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins., Metab. Clin. Exp.
Lam et al., 2005, Fourier transform infrared spectroscopy evaluation of low density lipoprotein oxidation in the presence of quercetin, catechin, and alpha-tocopherol., Lipids
Parhofer et al., 1993, Effect of pravastatin on metabolic parameters of apolipoprotein B in patients with mixed hyperlipoproteinemia., Clin Investig
Wang et al., 1995, Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes., Arterioscler. Thromb. Vasc. Biol.
Mabile et al., 1995, alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells., Free Radic. Biol. Med.
Sjöberg et al., 1992, Effects of growth hormone on apolipoprotein-B (apoB) messenger ribonucleic acid editing, and apoB 48 and apoB 100 synthesis and secretion in the rat liver., Endocrinology
Yee et al., 2002, Green tea catechins decrease apolipoprotein B-100 secretion from HepG2 cells., Mol. Cell. Biochem.
Huff et al., 1985, Mevinolin and cholestyramine inhibit the direct synthesis of low density lipoprotein apolipoprotein B in miniature pigs., J. Lipid Res.
Petit et al., 2003, Increased VLDL-apoB and IDL-apoB production rates in nonlipodystrophic HIV-infected patients on a protease inhibitor-containing regimen: a stable isotope kinetic study., J. Lipid Res.
Watts et al., 2003, Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome., Diabetes
Field et al., 1995, Esterification of plasma membrane cholesterol and triacylglycerol-rich lipoprotein secretion in CaCo-2 cells: possible role of p-glycoprotein., J. Lipid Res.
Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens
Bakillah et al., 1998, Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein., Biochemistry
Krul et al., 1988, Regional specificities of monoclonal anti-human apolipoprotein B antibodies., J. Lipid Res.
Mohammadi et al., 1998, Effects of atorvastatin on the intracellular stability and secretion of apolipoprotein B in HepG2 cells., Arterioscler. Thromb. Vasc. Biol.
Miltiadous et al., 2005, Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia., Pharmacogenet. Genomics
Tsimikas et al., 2004, High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial., Circulation
Telford et al., 2003, Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB., J. Lipid Res.
Chan et al., 2002, Regulatory effects of HMG CoA reductase inhibitor and fish oils on apolipoprotein B-100 kinetics in insulin-resistant obese male subjects with dyslipidemia., Diabetes
Forster et al., 2002, Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates., Atherosclerosis
Pal et al., 2002, Cholesterol esters regulate apoB48 secretion in CaCo2 cells., Atherosclerosis
Burnett et al., 1999, The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs., Endocrinology
Wilcox et al., 1999, Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin., J. Lipid Res.
Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci

CHOLESTYRAMINE APOB

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3906004

Sources:
NCI
MIPOMERSEN APOB

Interaction Score: 1.49

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ISIS 301012

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
LOMITAPIDE APOB

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
IRBESARTAN APOB

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15614026

Sources:
PharmGKB
ATORVASTATIN APOB

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9598838 15864114 15353498 12562847 12145148 12119202 11882317 10537160 10357840

Sources:
NCI
FENOFIBRATE APOB

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12606523

Sources:
NCI PharmGKB
VITAMIN E APOB

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7649489

Sources:
NCI
LOVASTATIN APOB

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7662319 2351867 1588827

Sources:
NCI
NEVIRAPINE APOB

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12869587

Sources:
NCI
HEPARIN APOB

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9521691 2457642

Sources:
NCI
EPIGALOCATECHIN GALLATE APOB

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11936850

Sources:
NCI
TRIFLUOPERAZINE APOB

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7595077

Sources:
NCI
PRAVASTATIN APOB

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8312689

Sources:
NCI
HYDROCORTISONE APOB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1597147

Sources:
NCI
WARFARIN APOB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXAMETHASONE APOB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7670964

Sources:
NCI
ZINC CHLORIDE APOB

Interaction Score: 0.06

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
23896426

Sources:
DrugBank
QUERCETIN APOB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16149735

Sources:
NCI
ALCOHOL APOB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8576634

Sources:
NCI

Ensembl: ENSG00000084674
- Version: 101_38
Alternate Names:

APOB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04114
- Version: January-2014
Alternate Names:

APOB Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme cofactor

Publications:

RussLampel: ENSG00000084674

Version: 26-July-2011

Alternate Names:

APOLIPOPROTEIN B-100 PRECURSOR (APO B-100) [CONTAINS: APOLIPOPROTEIN B-48 (APO B-48)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04114] Description

ENSG00000084674 Ensembl Gene Id

APOB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P04114
- Version: 11-September-2012
Alternate Names:

P04114 Uniprot Accession

ENSG00000084674 Ensembl Gene Id

APOB_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR001747

Interpro Short Name Lipid_transpt_N

Interpro Name Lipid transport protein, N-terminal

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: APOB
- Version: 18-August-2020
Alternate Names:

PA50 PharmGKB ID

Gene Info:

Publications:

Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens
DrugBank: BE0009908
- Version: 5.1.7
Alternate Names:

APOB DrugBank Gene Name

P04114 UniProt Accession

338 Entrez Gene Id

Gene Info:

Publications:

Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci

NCI: APOB

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Arad et al., 1992, Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: evidence for reduced assembly and secretion of triglyceride-rich lipoproteins., Metab. Clin. Exp.

Arad et al., 1990, Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: implications for the pathophysiology of apoB production., J. Lipid Res.

Pau et al., Inhibition of hydroxymethylglutaryl coenzyme A reductase activity does not affect the secretion rate of apolipoproteins B and AI by CaCo-2 cells., Biochem. Cell Biol.

HingoraniCasas: ENSG00000084674
- Version: 31-May-2017
Alternate Names:

ENSG00000084674 Gene Symbol

APOB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: APOB
- Version: 11-November-2018
Alternate Names:

APOB Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Apolipoprotein B-100
- Version: 2020.06.01
Alternate Names:

APOB TTD Gene Abbreviation

T07533 TTD Target ID

Gene Info:

Publications:

APOLIPOPROTEIN B-100 PRECURSOR (APO B-100) [CONTAINS: APOLIPOPROTEIN B-48 (APO B-48)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04114]	Description
ENSG00000084674	Ensembl Gene Id
APOB	Display Id

P04114	Uniprot Accession
ENSG00000084674	Ensembl Gene Id
APOB_HUMAN	Uniprot Id

APOB	DrugBank Gene Name
P04114	UniProt Accession
338	Entrez Gene Id

Trial Name	ISIS 301012
Novel drug target	Novel Target

APOB Gene Record

APOB 338 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3906004

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ISIS 301012 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15614026

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9598838 15864114 15353498 12562847 12145148 12119202 11882317 10537160 10357840

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12606523

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7649489

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7662319 2351867 1588827

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12869587

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9521691 2457642

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11936850

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7595077

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8312689

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1597147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7670964

Sources: NCI

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 23896426

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16149735

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
3906004

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ISIS 301012

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15614026

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9598838 15864114 15353498 12562847 12145148 12119202 11882317 10537160 10357840

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12606523

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7649489

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7662319 2351867 1588827

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12869587

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9521691 2457642

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11936850

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7595077

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8312689

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1597147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7670964

Sources:
NCI

Interaction Types & Directionality:

ligand

PMIDs:
23896426

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16149735

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8576634

Sources:
NCI

Alternate Names:

APOB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

APOB Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme cofactor

Alternate Names:

APOLIPOPROTEIN B-100 PRECURSOR (APO B-100) [CONTAINS: APOLIPOPROTEIN B-48 (APO B-48)]. [SOURCE:UNIPROT/SWISSPROT;ACC:P04114] Description

ENSG00000084674 Ensembl Gene Id

APOB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P04114 Uniprot Accession

ENSG00000084674 Ensembl Gene Id

APOB_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR001747

Interpro Short Name Lipid_transpt_N

Interpro Name Lipid transport protein, N-terminal

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA50 PharmGKB ID

Publications:

Liljedahl U et al., 2004, Single nucleotide polymorphisms predict the change in left ventricular mass in response to antihypertensive treatment., J Hypertens

Alternate Names:

APOB DrugBank Gene Name

P04114 UniProt Accession

338 Entrez Gene Id

Publications:

Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci

Alternate Names:

ENSG00000084674 Gene Symbol

APOB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

APOB Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

APOB TTD Gene Abbreviation

T07533 TTD Target ID