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APOE Gene Record

  • Summary
  • Interactions
  • Claims
  • APOE 348 Druggable Genome

    Alternate Names:

    348
    APOLIPOPROTEIN E
    APOE
    AD2
    APO-E
    ApoE4
    LDLCQ5
    LPG
    107741
    613
    ENSG00000130203
    OTTHUMG00000128901
    PA55
    T21689

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
    Pomara et al., 2005, Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults., Arch. Gen. Psychiatry
    Brisson D et al., 2002, Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients., Pharmacogenetics
    Arnedo M et al., 2007, Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy., Pharmacogenet Genomics
    Tarr PE et al., 2005, Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders., J Infect Dis
    Chiba et al., 1997, Effects of triamcinolone on brain and cerebrospinal fluid apolipoprotein E levels in rats., Life Sci.
    Khallou-Laschet et al., 2006, The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease., Arterioscler. Thromb. Vasc. Biol.
    Gerdes LU et al., 2000, The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction : a substudy of the Scandinavian simvastatin survival study., Circulation
    Williams et al., 1986, Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts., J. Lipid Res.
    Xiang Q et al., 2018, The association between the SLCO1B1, apolipoprotein E, and CYP2C9 genes and lipid response to fluvastatin: a meta-analysis., Pharmacogenet Genomics
    Zuccaro P et al., 2007, Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin., Pharmacol Res
    Thompson JF et al., 2009, Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort., Circ Cardiovasc Genet
    Mega JL et al., 2009, Identification of genetic variants associated with response to statin therapy., Arterioscler Thromb Vasc Biol
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Pons et al., 2003, Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure., J. Cardiovasc. Pharmacol.
    Kitagawa et al., 2002, Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action., J. Neurosci. Res.
    Bryk AH et al., 2018, Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms., Vascul Pharmacol
    Dwyer et al., 2001, Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study., Circulation
    Cavallari LH et al., 2011, Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients., Pharmacotherapy
    Cefalu et al., 2004, Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice., Acta Diabetol
  • LUTEIN   APOE

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11413081


    Sources:
    NCI

  • GANCICLOVIR   APOE

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16322528


    Sources:
    NCI

  • SOYBEAN OIL   APOE

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3021887


    Sources:
    NCI

  • ACENOCOUMAROL   APOE

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29432897


    Sources:
    PharmGKB

  • IRBESARTAN   APOE

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12827021


    Sources:
    NCI

  • RITONAVIR   APOE

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17700364 15809899


    Sources:
    PharmGKB

  • FLUVASTATIN   APOE

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30363031 17289397


    Sources:
    PharmGKB

  • LORAZEPAM   APOE

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15699298


    Sources:
    NCI

  • TRIAMCINOLONE   APOE

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9150415


    Sources:
    NCI

  • PRAVASTATIN   APOE

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19667110 17289397


    Sources:
    PharmGKB

  • WARFARIN   APOE

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29432897 21923605


    Sources:
    PharmGKB

  • ATORVASTATIN   APOE

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20031582 19667110 17289397 16103896


    Sources:
    PharmGKB

  • TROGLITAZONE   APOE

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15057551


    Sources:
    NCI

  • STAUROSPORINE   APOE

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11948667


    Sources:
    NCI

  • FENOFIBRATE   APOE

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12042669


    Sources:
    PharmGKB

  • PREDNISONE   APOE

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3185288


    Sources:
    NCI

  • SIMVASTATIN   APOE

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10736278


    Sources:
    PharmGKB

  • Ensembl: ENSG00000130203

    • Version: 101_38

    Alternate Names:
    APOE Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: APOE

    • Version: 18-August-2020

    Alternate Names:
    PA55 PharmGKB ID

    Gene Info:

    Publications:
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Mega JL et al., 2009, Identification of genetic variants associated with response to statin therapy., Arterioscler Thromb Vasc Biol
    Thompson JF et al., 2009, Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort., Circ Cardiovasc Genet

  • NCI: APOE

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
    Pomara et al., 2005, Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults., Arch. Gen. Psychiatry
    Dwyer et al., 2001, Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study., Circulation

  • HingoraniCasas: ENSG00000130203

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000130203 Gene Symbol
    APOE Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Apolipoprotein E

    • Version: 2020.06.01

    Alternate Names:
    APOE TTD Gene Abbreviation
    T21689 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21