DGIdb - APOE Gene Record

APOE 348 Druggable Genome

Alternate Names:

348
APOLIPOPROTEIN E
APOE
AD2
APO-E
ApoE4
LDLCQ5
LPG
107741
613
ENSG00000130203
OTTHUMG00000128901
PA55
T21689

Gene Info:

Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.
Pomara et al., 2005, Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults., Arch. Gen. Psychiatry
Brisson D et al., 2002, Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients., Pharmacogenetics
Arnedo M et al., 2007, Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy., Pharmacogenet Genomics
Tarr PE et al., 2005, Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders., J Infect Dis
Chiba et al., 1997, Effects of triamcinolone on brain and cerebrospinal fluid apolipoprotein E levels in rats., Life Sci.
Khallou-Laschet et al., 2006, The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease., Arterioscler. Thromb. Vasc. Biol.
Gerdes LU et al., 2000, The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction : a substudy of the Scandinavian simvastatin survival study., Circulation
Williams et al., 1986, Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts., J. Lipid Res.
Xiang Q et al., 2018, The association between the SLCO1B1, apolipoprotein E, and CYP2C9 genes and lipid response to fluvastatin: a meta-analysis., Pharmacogenet Genomics
Zuccaro P et al., 2007, Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin., Pharmacol Res
Thompson JF et al., 2009, Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort., Circ Cardiovasc Genet
Mega JL et al., 2009, Identification of genetic variants associated with response to statin therapy., Arterioscler Thromb Vasc Biol
Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
Pons et al., 2003, Effects of angiotensin II type 1 receptor blockade in ApoE-deficient mice with post-ischemic heart failure., J. Cardiovasc. Pharmacol.
Kitagawa et al., 2002, Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action., J. Neurosci. Res.
Bryk AH et al., 2018, Bleeding predictors in patients following venous thromboembolism treated with vitamin K antagonists: Association with increased number of single nucleotide polymorphisms., Vascul Pharmacol
Dwyer et al., 2001, Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study., Circulation
Cavallari LH et al., 2011, Association of apolipoprotein E genotype with duration of time to achieve a stable warfarin dose in African-American patients., Pharmacotherapy
Cefalu et al., 2004, Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice., Acta Diabetol

LUTEIN APOE

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11413081

Sources:
NCI
GANCICLOVIR APOE

Interaction Score: 1.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16322528

Sources:
NCI
SOYBEAN OIL APOE

Interaction Score: 1.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3021887

Sources:
NCI
ACENOCOUMAROL APOE

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29432897

Sources:
PharmGKB
IRBESARTAN APOE

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12827021

Sources:
NCI
RITONAVIR APOE

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17700364 15809899

Sources:
PharmGKB
FLUVASTATIN APOE

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30363031 17289397

Sources:
PharmGKB
TRIAMCINOLONE APOE

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9150415

Sources:
NCI
LORAZEPAM APOE

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15699298

Sources:
NCI
PRAVASTATIN APOE

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19667110 17289397

Sources:
PharmGKB
WARFARIN APOE

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29432897 21923605

Sources:
PharmGKB
ATORVASTATIN APOE

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20031582 19667110 17289397 16103896

Sources:
PharmGKB
TROGLITAZONE APOE

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15057551

Sources:
NCI
FENOFIBRATE APOE

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12042669

Sources:
PharmGKB
PREDNISONE APOE

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3185288

Sources:
NCI
STAUROSPORINE APOE

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11948667

Sources:
NCI
SIMVASTATIN APOE

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10736278

Sources:
PharmGKB

Ensembl: ENSG00000130203
- Version: 101_38
Alternate Names:

APOE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: APOE

Version: 18-August-2020

Alternate Names:

PA55 PharmGKB ID

Gene Info:

Publications:

Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

Mega JL et al., 2009, Identification of genetic variants associated with response to statin therapy., Arterioscler Thromb Vasc Biol

Thompson JF et al., 2009, Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort., Circ Cardiovasc Genet

NCI: APOE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ettinger et al., 1988, Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men., Metab. Clin. Exp.

Pomara et al., 2005, Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults., Arch. Gen. Psychiatry

Dwyer et al., 2001, Oxygenated carotenoid lutein and progression of early atherosclerosis: the Los Angeles atherosclerosis study., Circulation

HingoraniCasas: ENSG00000130203
- Version: 31-May-2017
Alternate Names:

ENSG00000130203 Gene Symbol

APOE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Apolipoprotein E
- Version: 2020.06.01
Alternate Names:

APOE TTD Gene Abbreviation

T21689 TTD Target ID

Gene Info:

Publications:

APOE Gene Record

APOE 348 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11413081

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16322528

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3021887

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29432897

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12827021

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17700364 15809899

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30363031 17289397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9150415

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15699298

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19667110 17289397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29432897 21923605

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20031582 19667110 17289397 16103896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15057551

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12042669

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3185288

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11948667

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10736278

Sources: PharmGKB

Ensembl: ENSG00000130203

Alternate Names: APOE Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: APOE

Alternate Names: PA55 PharmGKB ID

Interaction Types & Directionality:

n/a

PMIDs:
11413081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16322528

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3021887

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29432897

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12827021

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17700364 15809899

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30363031 17289397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9150415

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15699298

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19667110 17289397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29432897 21923605

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20031582 19667110 17289397 16103896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15057551

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12042669

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
3185288

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11948667

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10736278

Sources:
PharmGKB

Alternate Names:

APOE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA55 PharmGKB ID

Alternate Names:

ENSG00000130203 Gene Symbol

APOE Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

APOE TTD Gene Abbreviation

T21689 TTD Target ID