DGIdb - AREG Gene Record

AREG 374 Druggable GenomeDrug Resistance

Alternate Names:

374
AMPHIREGULIN
AREG
AR
AREGB
CRDGF
SDGF
104640
651
ENSG00000109321
OTTHUMG00000130006
389
ENSG00000205595
PA24933

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

CELL SURFACE
GROWTH FACTOR
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Seligmann et al., 2016, Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer., JAMA Oncol
Sebio A et al., 2014, Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan., Pharmacogenomics J
Sebio A et al., 2015, EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer., Pharmacogenomics J
Pentheroudakis et al., 2013, Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes., BMC Cancer
Sasaki et al., 2011, A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors., Cancer Res.

PANITUMUMAB AREG

Interaction Score: 2.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26867820 23959273

Sources:
CIViC PharmGKB
CRIZOTINIB AREG

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21791641

Sources:
CIViC
CETUXIMAB AREG

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23959273 23374602

Sources:
CIViC PharmGKB
CAPECITABINE AREG

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25026457

Sources:
PharmGKB
IRINOTECAN AREG

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23959273

Sources:
PharmGKB

Ensembl: ENSG00000109321
- Version: 101_38
Alternate Names:

AREG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: AREG

Version: 18-August-2020

Alternate Names:

PA24933 PharmGKB ID

Gene Info:

Publications:

Sebio A et al., 2015, EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer., Pharmacogenomics J

Sebio A et al., 2014, Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan., Pharmacogenomics J

CIViC: AREG

Version: 14-September-2020

Alternate Names:

374 Entrez Gene ID

389 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Pentheroudakis et al., 2013, Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes., BMC Cancer

Seligmann et al., 2016, Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer., JAMA Oncol

Sasaki et al., 2011, A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors., Cancer Res.

HingoraniCasas: ENSG00000205595
- Version: 31-May-2017
Alternate Names:

ENSG00000205595 Gene Symbol

AREGB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000109321
- Version: 31-May-2017
Alternate Names:

ENSG00000109321 Gene Symbol

AREG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: AREG
- Version: 05-September-2020
Alternate Names:

AREGB GO Gene Synonym

SDGF GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, GROWTH FACTOR

Publications:

AREG Gene Record

AREG 374 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PANITUMUMAB AREG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26867820 23959273

Sources: CIViC PharmGKB

CRIZOTINIB AREG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21791641

Sources: CIViC

CETUXIMAB AREG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23959273 23374602

Sources: CIViC PharmGKB

CAPECITABINE AREG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25026457

Sources: PharmGKB

IRINOTECAN AREG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23959273

Sources: PharmGKB

Ensembl: ENSG00000109321

Alternate Names: AREG Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: AREG

Alternate Names: PA24933 PharmGKB ID

Gene Info:

CIViC: AREG

Alternate Names: 374 Entrez Gene ID 389 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

HingoraniCasas: ENSG00000205595

Alternate Names: ENSG00000205595 Gene Symbol AREGB Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HingoraniCasas: ENSG00000109321

Alternate Names: ENSG00000109321 Gene Symbol AREG Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: AREG

Alternate Names: AREGB GO Gene Synonym SDGF GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, GROWTH FACTOR

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
26867820 23959273

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21791641

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23959273 23374602

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25026457

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23959273

Sources:
PharmGKB

Alternate Names:

AREG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA24933 PharmGKB ID

Alternate Names:

374 Entrez Gene ID

389 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

ENSG00000205595 Gene Symbol

AREGB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000109321 Gene Symbol

AREG Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

AREGB GO Gene Synonym

SDGF GO Gene Synonym

Gene Categories:

CELL SURFACE, GROWTH FACTOR