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ARNT Gene Record

  • Summary
  • Interactions
  • Claims
  • ARNT 405 Druggable GenomeClinically Actionable

    Alternate Names:

    405
    ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR
    ARNT
    HIF-1-beta
    HIF-1beta
    HIF1-beta
    HIF1B
    HIF1BETA
    TANGO
    bHLHe2
    126110
    700
    ENSG00000143437
    OTTHUMG00000035011

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Abbott et al., 1999, RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone., Toxicol. Sci.
    Liu Y et al., 2008, Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells., J Nat Prod
    Zhou YD et al., 2004, Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts., J Nat Prod
  • FUROSPONGOLIDE   ARNT

    Interaction Score: 20.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18989978


    Sources:
    DTC

  • EPICATECHIN GALLATE   ARNT

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15620252


    Sources:
    DTC

  • HYDROCORTISONE   ARNT

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10048155


    Sources:
    NCI

  • Ensembl: ENSG00000143437

    • Version: 101_38

    Alternate Names:
    ARNT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: ARNT

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lees et al., 1999, Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt., Mol. Cell. Biol.
    Abbott et al., 1998, AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGF alpha, TGF beta 1, TGF beta 2, and TGF beta 3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)., Teratology
    Dasmahapatra et al., 2000, Demonstration of 2,3,7,8-tetrachlorodibenzo-p-dioxin attenuation of P450 steroidogenic enzyme mRNAs in rat granulosa cell in vitro by competitive reverse transcriptase-polymerase chain reaction assay., Mol. Cell. Endocrinol.

  • DTC: ARNT

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Zhou YD et al., 2004, Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts., J Nat Prod
    Liu Y et al., 2008, Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells., J Nat Prod

  • HingoraniCasas: ENSG00000143437

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000143437 Gene Symbol
    ARNT Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ARNT

    • Version: 01-February-2022

    Alternate Names:
    BHLHE2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • FoundationOneGenes: ARNT

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: ARNT

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21