DGIdb - AURKA Gene Record

AURKA 6790 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

6790
AURORA KINASE A
AURKA
AIK
ARK1
AURA
BTAK
PPP1R47
STK15
STK6
STK7
603072
11393
ENSG00000087586
OTTHUMG00000032796
O14965
AURKA_HUMAN
Aurora 2
hARK1
Serine/threonine-protein kinase 6
Serine/threonine-protein kinase 15
AYK1
Breast tumor-amplified kinase
Aurora/IPL1-related kinase 1
ARK-1
IAK1
Serine/threonine-protein kinase aurora-A
AIRK1
Aurora-related kinase 1
BE0000991
61
O14695
Aurora A/B/C
Aurora A
SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965]
1936
NP_003591
NM_003600
T87675
AURORA2

Gene Info:

Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Human Readable Name	KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Uniprot Evidence	1: Evidence at protein level
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
GuideToPharmacology Gene Category Name	Aurora kinase (Aur) family
GuideToPharmacology Gene Category ID	557
CancerCommons Reported Gene Name	Aurora Kinase
Gene Biotype	PROTEIN_CODING

(20 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Xu et al., 2014, Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis., J Transl Med
Tamotsu et al., 2015, Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma., BMC Cancer
Manfredi MG et al., 2007, Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase., Proc Natl Acad Sci U S A
Cee VJ et al., 2010, Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor., J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Wang S et al., 2010, Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors., J Med Chem
Angiolini M et al., 2010, Structure-based optimization of potent PDK1 inhibitors., Bioorg Med Chem Lett
Anand et al., 2003, AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol., Cancer Cell
Zheng et al., 2014, Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer., Oncogene
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL521105 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL223147 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL495758 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
ANILINOPYRIMIDINE1 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL472193 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
TAS-119 AURKA

Interaction Score: 1.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MK-5108 AURKA

Interaction Score: 1.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD
PF-03814735 AURKA

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
CHEMBL522891 AURKA

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
NERVIANO AURKA

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20621725

Sources:
DTC
DANUSERTIB AURKA

Interaction Score: 0.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD
AMG-900 AURKA

Interaction Score: 0.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology
AT-9283 AURKA

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC DrugBank MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
KW-2449 AURKA

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
MK-6592 AURKA

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DUBERMATINIB AURKA

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
GSK-1070916 AURKA

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
EUPATORIN AURKA

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TTP-607 AURKA

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ENMD-2076 AURKA

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD
NORHARMANE AURKA

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BARASERTIB AURKA

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC GuideToPharmacology
MLN-8054 AURKA

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
17360485 20684549

Sources:
DTC DrugBank ChemblInteractions GuideToPharmacology
ALISERTIB AURKA

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Notes

PMIDs:
None found

Sources:
TALC DTC DrugBank MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons MyCancerGenomeClinicalTrial
SNS-314 AURKA

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SNS-314

Novel drug target Novel Target

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
TALC DTC DrugBank MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
CHEMBL1765740 AURKA

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DIMETHYLADENINE AURKA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB AURKA

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
19035792

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
ENZASTAURIN AURKA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
XL-228 AURKA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name XL228

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL202721 AURKA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-1152-HQPA AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC DTC DrugBank MyCancerGenome ChemblInteractions
CHEMBL578061 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
ILORASERTIB AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC ChemblInteractions GuideToPharmacology TTD
ENMD-981693 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RG-1530 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC ChemblInteractions GuideToPharmacology
CHEMBL546797 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
20462263

Sources:
DTC ChemblInteractions
TAMOXIFEN AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24166501

Sources:
CIViC
AST-487 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
OSI-632 AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAZOPANIB AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12559175

Sources:
CIViC
CISPLATIN AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25082261 25924824

Sources:
CIViC
PF-00562271 AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
FLUOROURACIL AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25924824

Sources:
CIViC
ENTRECTINIB AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 AURKA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB AURKA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 AURKA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB AURKA

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000087586
- Version: 101_38
Alternate Names:

AURKA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: O14965
- Version: 11-September-2012
Alternate Names:

ENSG00000087586 Ensembl Gene Id

AURKA_HUMAN Uniprot Id

O14965 Uniprot Accession

Gene Info:

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Type Domain

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: O14965
- Version: January-2014
Alternate Names:

AURKA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
CancerCommons: AURKA
- Version: 25-July-2013
Alternate Names:

6790 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Aurora Kinase

Publications:
TdgClinicalTrial: O14695
- Version: January-2014
Alternate Names:

AURKA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:

RussLampel: ENSG00000087586

Version: 26-July-2011

Alternate Names:

ENSG00000087586 Ensembl Gene Id

SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965] Description

AURKA Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6790
- Version: 29-September-2020
Alternate Names:

11393 HUGO Gene ID

11393 HUGO Gene Symbol

aurora kinase A HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Aurora kinase (Aur) family

GuideToPharmacology Gene Category ID 557

Gene Categories:

ENZYME

Publications:

CIViC: AURKA

Version: 14-September-2020

Alternate Names:

6790 Entrez Gene ID

61 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Mignogna et al., 2016, Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients., J Ovarian Res

Zheng et al., 2014, Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer., Oncogene

Tamotsu et al., 2015, Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma., BMC Cancer

DrugBank: BE0000991

Version: 5.1.7

Alternate Names:

AURKA DrugBank Gene Name

O14965 UniProt Accession

6790 Entrez Gene Id

Gene Info:

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

DTC: AURKA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Kishore AH et al., 2008, Specific small-molecule activator of Aurora kinase A induces autophosphorylation in a cell-free system., J Med Chem

Angiolini M et al., 2010, Structure-based optimization of potent PDK1 inhibitors., Bioorg Med Chem Lett

TALC: AURORA A
- Version: 12-May-2016
Alternate Names:

AURORA A Gene Symbol

Gene Info:

Publications:
MyCancerGenome: AURKA
- Version: 20-Jun-2017
Alternate Names:

6790 Entrez Gene Id

AURKA MyCancerGenome Gene Symbol

Aurora A MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000087586
- Version: 31-May-2017
Alternate Names:

ENSG00000087586 Gene Symbol

AURKA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: AIK
- Version: chembl_23
Alternate Names:

AIRK1 GENE_SYMBOL

ARK1 GENE_SYMBOL

AURA GENE_SYMBOL

Gene Info:

Publications:
Pharos: AURKA
- Version: 03-September-2020
Alternate Names:

Aurora kinase A Gene Name

O14965 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: AURKA
- Version: 05-September-2020
Alternate Names:

AIK GO Gene Synonym

AIRK1 GO Gene Synonym

ARK1 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Tempus: AURKA
- Version: 11-November-2018
Alternate Names:

AURKA Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: AURKA
- Version: 27-Jun-2013
Alternate Names:

6790 Gene ID

AIK dGene Synonym

ARK1 dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
TTD: Aurora kinase A
- Version: 2020.06.01
Alternate Names:

AURKA TTD Gene Abbreviation

T87675 TTD Target ID

Gene Info:

Publications:
MskImpact: AURKA
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: AURKA
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: AURKA
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: AURKA
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: AURKA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Notes
Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase Aurora inhibitor
Notes

Novel drug target	Novel Target
Trial Name	ENMD-2076
Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor

Trial Name	SNS-314
Novel drug target	Novel Target
Mechanism of Interaction	Serine/threonine-protein kinase Aurora inhibitor

ENSG00000087586	Ensembl Gene Id
AURKA_HUMAN	Uniprot Id
O14965	Uniprot Accession

11393	HUGO Gene ID
11393	HUGO Gene Symbol
aurora kinase A	HUGO Gene Name

AURKA	DrugBank Gene Name
O14965	UniProt Accession
6790	Entrez Gene Id

AURKA Gene Record

AURKA 6790 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20621725

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC DrugBank MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20621725

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC DrugBank MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)