DGIdb - AURKA Gene Record

AURKA 6790 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

6790
AURORA KINASE A
AURKA
AIK
ARK1
AURA
BTAK
PPP1R47
STK15
STK6
STK7
603072
11393
ENSG00000087586
OTTHUMG00000032796
O14965
AURKA_HUMAN
Aurora 2
hARK1
Serine/threonine-protein kinase 6
Serine/threonine-protein kinase 15
AYK1
Breast tumor-amplified kinase
Aurora/IPL1-related kinase 1
ARK-1
IAK1
Serine/threonine-protein kinase aurora-A
AIRK1
Aurora-related kinase 1
61
O14695
Aurora A/B/C
Aurora A
SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965]
1936
NP_003591
NM_003600
T87675
AURORA2

Gene Info:

Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Human Readable Name	KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Uniprot Evidence	1: Evidence at protein level
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
GuideToPharmacology Gene Category Name	Aurora kinase (Aur) family
GuideToPharmacology Gene Category ID	557
CancerCommons Reported Gene Name	Aurora Kinase
Gene Biotype	PROTEIN_CODING

(19 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Xu et al., 2014, Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis., J Transl Med
Tamotsu et al., 2015, Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma., BMC Cancer
Manfredi MG et al., 2007, Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase., Proc Natl Acad Sci U S A
Cee VJ et al., 2010, Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor., J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Wang S et al., 2010, Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors., J Med Chem
Angiolini M et al., 2010, Structure-based optimization of potent PDK1 inhibitors., Bioorg Med Chem Lett
Anand et al., 2003, AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol., Cancer Cell
Zheng et al., 2014, Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer., Oncogene

TAS-119 AURKA

Interaction Score: 2.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MK-5108 AURKA

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD
PF-03814735 AURKA

Interaction Score: 1.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
NERVIANO AURKA

Interaction Score: 1.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20621725

Sources:
DTC
DANUSERTIB AURKA

Interaction Score: 1.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD
AMG-900 AURKA

Interaction Score: 1.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology
AT-9283 AURKA

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
KW-2449 AURKA

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
MK-6592 AURKA

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DUBERMATINIB AURKA

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
GSK-1070916 AURKA

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
EUPATORIN AURKA

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TTP-607 AURKA

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ENMD-2076 AURKA

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD
NORHARMANE AURKA

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BARASERTIB AURKA

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC GuideToPharmacology
ALISERTIB AURKA

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Notes

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons MyCancerGenomeClinicalTrial
MLN-8054 AURKA

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
17360485 20684549

Sources:
DTC ChemblInteractions GuideToPharmacology
CHEMBL1765740 AURKA

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SNS-314 AURKA

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SNS-314

Novel drug target Novel Target

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
DIMETHYLADENINE AURKA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB AURKA

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
19035792

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
XL-228 AURKA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name XL228

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL202721 AURKA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-1152-HQPA AURKA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578061 AURKA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 AURKA

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
ILORASERTIB AURKA

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC ChemblInteractions GuideToPharmacology TTD
ENMD-981693 AURKA

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RG-1530 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC ChemblInteractions GuideToPharmacology
CENISERTIB AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome ChemblInteractions
TAMOXIFEN AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24166501

Sources:
CIViC
CHEMBL546797 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
20462263

Sources:
DTC ChemblInteractions
AST-487 AURKA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
PAZOPANIB AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12559175

Sources:
CIViC
CISPLATIN AURKA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25082261 25924824

Sources:
CIViC
PF-00562271 AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
FLUOROURACIL AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25924824

Sources:
CIViC
ENTRECTINIB AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB AURKA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 AURKA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000087586
- Version: 101_38
Alternate Names:

AURKA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: O14965
- Version: 11-September-2012
Alternate Names:

ENSG00000087586 Ensembl Gene Id

AURKA_HUMAN Uniprot Id

O14965 Uniprot Accession

Gene Info:

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Type Domain

Human Readable Name KINASE

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: O14965
- Version: January-2014
Alternate Names:

AURKA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
CancerCommons: AURKA
- Version: 25-July-2013
Alternate Names:

6790 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Aurora Kinase

Publications:
TdgClinicalTrial: O14695
- Version: January-2014
Alternate Names:

AURKA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:

RussLampel: ENSG00000087586

Version: 26-July-2011

Alternate Names:

ENSG00000087586 Ensembl Gene Id

SERINE/THREONINE-PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE KINASE 15) (AURORA/IPL1-RELATED KINASE 1) (AURORA-RELATED KINASE 1) (HARK1) (AURORA-A) (BREAST-TUMOR-AMPLIFIED KINASE). [SOURCE:UNIPROT/SWISSPROT;ACC:O14965] Description

AURKA Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6790
- Version: 29-September-2020
Alternate Names:

11393 HUGO Gene ID

11393 HUGO Gene Symbol

aurora kinase A HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Aurora kinase (Aur) family

GuideToPharmacology Gene Category ID 557

Gene Categories:

ENZYME

Publications:

CIViC: AURKA

Version: 14-September-2020

Alternate Names:

6790 Entrez Gene ID

61 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Mignogna et al., 2016, Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients., J Ovarian Res

Zheng et al., 2014, Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer., Oncogene

Tamotsu et al., 2015, Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma., BMC Cancer

DTC: AURKA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Kishore AH et al., 2008, Specific small-molecule activator of Aurora kinase A induces autophosphorylation in a cell-free system., J Med Chem

Angiolini M et al., 2010, Structure-based optimization of potent PDK1 inhibitors., Bioorg Med Chem Lett

TALC: AURORA A
- Version: 12-May-2016
Alternate Names:

AURORA A Gene Symbol

Gene Info:

Publications:
MyCancerGenome: AURKA
- Version: 20-Jun-2017
Alternate Names:

6790 Entrez Gene Id

AURKA MyCancerGenome Gene Symbol

Aurora A MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000087586
- Version: 31-May-2017
Alternate Names:

ENSG00000087586 Gene Symbol

AURKA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: AIK
- Version: chembl_23
Alternate Names:

AIRK1 GENE_SYMBOL

ARK1 GENE_SYMBOL

AURA GENE_SYMBOL

Gene Info:

Publications:
Tempus: AURKA
- Version: 11-November-2018
Alternate Names:

AURKA Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: AURKA
- Version: 27-Jun-2013
Alternate Names:

6790 Gene ID

AIK dGene Synonym

ARK1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Aurora kinase A
- Version: 2020.06.01
Alternate Names:

AURKA TTD Gene Abbreviation

T87675 TTD Target ID

Gene Info:

Publications:
GO: AURKA
- Version: 01-May-2021
Alternate Names:

AIK GO Gene Synonym

AIRK1 GO Gene Synonym

ARK1 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: AURKA
- Version: 01-May-2021
Alternate Names:

Aurora kinase A Gene Name

O14965 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: AURKA
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: AURKA
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: AURKA
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: AURKA
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: AURKA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Notes
Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase Aurora inhibitor
Notes

Novel drug target	Novel Target
Trial Name	ENMD-2076
Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor

Trial Name	SNS-314
Novel drug target	Novel Target
Mechanism of Interaction	Serine/threonine-protein kinase Aurora inhibitor

ENSG00000087586	Ensembl Gene Id
AURKA_HUMAN	Uniprot Id
O14965	Uniprot Accession

11393	HUGO Gene ID
11393	HUGO Gene Symbol
aurora kinase A	HUGO Gene Name

6790	Entrez Gene Id
AURKA	MyCancerGenome Gene Symbol
Aurora A	MyCancerGenome Reported Gene Name

AURKA Gene Record

AURKA 6790 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20621725

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name ENMD-2076 Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor Notes

PMIDs: None found

Sources: TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor Specific Action of the Ligand Inhibition

PMIDs: 17360485 20684549

Sources: DTC ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20621725

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Notes

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
17360485 20684549

Sources:
DTC ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name SNS-314

Novel drug target Novel Target

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC