DGIdb - AURKB Gene Record

AURKB 9212 Druggable GenomeClinically Actionable

Alternate Names:

9212
AURORA KINASE B
AURKB
AIK2
AIM-1
AIM1
ARK-2
ARK2
AurB
IPL1
PPP1R48
STK-1
STK12
STK5
aurkb-sv1
aurkb-sv2
604970
11390
ENSG00000178999
OTTHUMG00000108189
Q96GD4
AIRK2
STK1
AURKB_HUMAN
SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4]
AURORA- AND IPL1-LIKE MIDBODY-ASSOCIATED PROTEIN 1
AURORA/IPL1-RELATED KINASE 2
AURORA-RELATED KINASE 2
Serine/threonine-protein kinase 5
Serine/threonine-protein kinase 12
Aurora 1
Serine/threonine-protein kinase aurora-B
Aurora B
Aurora A/B/C
T46781

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.11.1
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR002290
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
HISTONE MODIFICATION
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Cee VJ et al., 2010, Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor., J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Shiao HY et al., 2013, Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor., J Med Chem
Kollareddy M et al., 2012, Aurora kinase inhibitors: progress towards the clinic., Invest New Drugs
Wang S et al., 2010, Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors., J Med Chem
Wang HC et al., 2014, Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor., Eur J Med Chem
Kusakabe K et al., 2013, Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)., J Med Chem
Angiolini M et al., 2010, Structure-based optimization of potent PDK1 inhibitors., Bioorg Med Chem Lett
Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
Manfredi MG et al., 2007, Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase., Proc Natl Acad Sci U S A
Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

BI-811283 AURKB

Interaction Score: 3.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
22350019

Sources:
ChemblInteractions TTD
GSK-1070916 AURKB

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD
TAK-901 AURKB

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PF-03814735 AURKB

Interaction Score: 1.6

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
NERVIANO AURKB

Interaction Score: 1.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20621725

Sources:
DTC
DANUSERTIB AURKB

Interaction Score: 1.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD
AMG-900 AURKB

Interaction Score: 0.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions
MK-5108 AURKB

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
AT-9283 AURKB

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Novel drug target Novel Target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
BARASERTIB AURKB

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs:
20684549

Sources:
DTC MyCancerGenome ChemblInteractions
EUPATORIN AURKB

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MK-6592 AURKB

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TTP-607 AURKB

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CHIAURANIB AURKB

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KW-2449 AURKB

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
WITHAFERIN A AURKB

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24079846

Sources:
DTC
CHEMBL259850 AURKB

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BMS-754807 AURKB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
CHEMBL375293 AURKB

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-1152-HQPA AURKB

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25036791

Sources:
DTC TTD
SNS-314 AURKB

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
BMS-345541 AURKB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL535331 AURKB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2005186 AURKB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB AURKB

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
19035792 23808327

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TTD
MLN-8054 AURKB

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17360485

Sources:
DTC
CHEMBL202721 AURKB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENMD-2076 AURKB

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAPATINIB AURKB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FASUDIL AURKB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL546797 AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
20462263

Sources:
DTC ChemblInteractions
ILORASERTIB AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions TTD
CHEMBL541400 AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
HESPERADIN AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
PAZOPANIB AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALISERTIB AURKB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL379975 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-269962A AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTOLISIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23634759

Sources:
DTC
CEDIRANIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERLOTINIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VANDETANIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DASATINIB AURKB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB AURKB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB AURKB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 AURKB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 AURKB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000178999
- Version: 101_38
Alternate Names:

AURKB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q96GD4
- Version: 11-September-2012
Alternate Names:

Q96GD4 Uniprot Accession

9212 Entrez Gene Id

AURKB_HUMAN Uniprot Id

Gene Info:

Human Readable Name KINASE

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Uniprot Status Swiss-Prot

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000178999

Version: 26-July-2011

Alternate Names:

ENSG00000178999 Ensembl Gene Id

SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4] Description

AURKB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q96GD4
- Version: January-2014
Alternate Names:

AURKB Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
TTD: Aurora kinase B
- Version: 2020.06.01
Alternate Names:

AURKB TTD Gene Abbreviation

T46781 TTD Target ID

Gene Info:

Publications:

Kollareddy M et al., 2012, Aurora kinase inhibitors: progress towards the clinic., Invest New Drugs

DTC: AURKB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Manfredi MG et al., 2007, Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase., Proc Natl Acad Sci U S A

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Shiao HY et al., 2013, Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor., J Med Chem

HingoraniCasas: ENSG00000178999
- Version: 31-May-2017
Alternate Names:

ENSG00000178999 Gene Symbol

AURKB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: AURORA B
- Version: 12-May-2016
Alternate Names:

AURORA B Gene Symbol

Gene Info:

Publications:
MyCancerGenome: AURKB
- Version: 20-Jun-2017
Alternate Names:

9212 Entrez Gene Id

AURKB MyCancerGenome Gene Symbol

Aurora A/B/C MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: AIK2
- Version: chembl_23
Alternate Names:

AIM1 GENE_SYMBOL

AIRK2 GENE_SYMBOL

ARK2 GENE_SYMBOL

Gene Info:

Publications:
HumanProteinAtlas: AURKB
- Version: 19.3
Alternate Names:

ENSG00000178999 Ensembl Gene ID

Aik2 Human Protein Atlas Gene Synonym

AIM-1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: AURKB
- Version: 01-February-2022
Alternate Names:

AIK2 GO Gene Synonym

AIM1 GO Gene Synonym

AIRK2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, HISTONE MODIFICATION

Publications:
Tempus: AURKB
- Version: 11-November-2018
Alternate Names:

AURKB Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: AURKB
- Version: 27-Jun-2013
Alternate Names:

9212 Gene ID

AIK2 dGene Synonym

AIM-1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: AURKB
- Version: 01-February-2022
Alternate Names:

Aurora kinase B Gene Name

Q96GD4 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: AURKB
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: AURKB
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: AURKB
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: AURKB
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Serine/threonine-protein kinase Aurora-B inhibitor
Direct Interaction	yes

Mechanism of Interaction	Serine/threonine-protein kinase Aurora inhibitor
Direct Interaction	yes
Notes

Q96GD4	Uniprot Accession
9212	Entrez Gene Id
AURKB_HUMAN	Uniprot Id

ENSG00000178999	Ensembl Gene Id
SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4]	Description
AURKB	Display Id

AURKB Gene Record

AURKB 9212 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Direct Interaction yes

PMIDs: 22350019

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20621725

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Novel drug target Novel Target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs: 20684549

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24079846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
22350019

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20621725

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Novel drug target Novel Target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs:
20684549

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24079846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25036791

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a