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BAX Gene Record

  • Summary
  • Interactions
  • Claims
  • BAX 581 Druggable Genome

    Alternate Names:

    581
    BCL2 ASSOCIATED X, APOPTOSIS REGULATOR
    BAX
    BCL2L4
    600040
    959
    ENSG00000087088
    OTTHUMG00000160476
    BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07815]
    Q07812
    APOPTOSIS REGULATOR BAX
    BAX_HUMAN

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name Bcl2_BH
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000712
    Interpro Name Apoptosis regulator, Bcl-2, BH
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    DRUGGABLE GENOME

    Publications:

    Paradiso et al., 2001, Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer., Br. J. Cancer
    Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
    Bosanquet et al., 2002, Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia., Leukemia
    Baghelai et al., 1999, Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis., J. Thorac. Cardiovasc. Surg.
    Osanai et al., 1997, Phenobarbital causes apoptosis in conditionally immortalized mouse hepatocytes depending on deregulated c-myc expression: characterization of an unexpected effect., Cancer Res.
    Wang et al., 1997, Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice., Cancer Lett.
    Madarová et al., 2001, Androgen sensitivity related proteins in hormone-sensitive and hormone-insensitive prostate cancer cell lines treated by androgen antagonist bicalutamide., Neoplasma
    Angelucci et al., Apoptosis-related gene expression affected by a GnRH analogue without induction of programmed cell death in LNCaP cells., Anticancer Res.
    Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
    Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.
    Vereide et al., 2005, Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone., Gynecol. Oncol.
    Hida et al., 2004, Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis., J. Lab. Clin. Med.
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
    Kim et al., 2005, Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells., J. Nutr. Biochem.
    Matsubara et al., 2000, Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells., J. Clin. Endocrinol. Metab.
    Yang et al., 2006, [Beneficial effects of carvedilol on cardiomyocyte apoptosis and bcl-2/bax expression after acute myocardial infarction an experiment with rats]., Zhonghua Yi Xue Za Zhi
    Zeng et al., 2003, Effects of carvedilol on cardiomyocyte apoptosis and gene expression in vivo after ischemia-reperfusion in rats., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Liu et al., 2001, Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells., Br. J. Cancer
    Huang et al., 2003, Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody., J. Surg. Res.
    Arango et al., 2004, Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells., Br. J. Cancer
    Hayward et al., 2004, Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect., Mol. Cancer Ther.
    Liu et al., 2004, Effects of L-tetrahydropalmatine on the expressions of bcl-2 and bax in rat after acute global cerebral ischemia and reperfusion., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Wuenschell et al., 2004, Nicotine-responsive genes in cultured embryonic mouse lung buds: interaction of nicotine and superoxide dismutase., Pharmacol. Res.
    Serafin et al., Influence of p53 and bcl-2 on chemosensitivity in benign and malignant prostatic cell lines., Urol. Oncol.
    Yamamoto et al., 1999, Synergistic action of apoptosis induced by eicosapentaenoic acid and TNP-470 on human breast cancer cells., Breast Cancer Res. Treat.
    Yoo et al., 2007, The additive effects of minoxidil and retinol on human hair growth in vitro., Biol. Pharm. Bull.
    Shchepotin et al., Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line., Int J Hyperthermia
    Takemura et al., 2005, Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy., J. Oral Pathol. Med.
    Xu et al., 2006, [Effect of erythromycin on apoptosis of epithelial cell in nasal polyps]., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
    Rassidakis et al., 2002, BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome., Clin. Cancer Res.
    Tirado et al., 2005, Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity., Oncogene
    Woo et al., 2005, Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity., Int. J. Oncol.
    Klingler et al., 1997, Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes., Infect. Immun.
    Aranha et al., 2003, Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis., Int. J. Oncol.
    Aranha et al., 2000, Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line., Clin. Cancer Res.
    Demyanets et al., 2006, Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro., Biochem. Pharmacol.
    Chen et al., 2006, [Effects of atenolol and metoprolol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction in rats]., Zhongguo Yi Xue Ke Xue Yuan Xue Bao
    Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.
    San-Emeterio et al., 2006, Modulation of brain apoptosis-related proteins by the opioid antagonist naltrexone in mice., Neurosci. Lett.
    Weller et al., 1997, Topoisomerase-I inhibitors for human malignant glioma: differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta-lapachone., Int. J. Cancer
    Kobylinska et al., 2004, Determination of the in vivo effects of cladribine alone and its combination with cyclophosphamide or cyclophosphamide and mitoxantrone on Bax and Bcl-2 protein expression in B-CLL cells., Oncol. Rep.
    Shibuya et al., 2003, Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins., Melanoma Res.
    Lee et al., 2005, Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line., Gynecol. Oncol.
    Liu et al., 2004, Neuroprotection by pergolide against levodopa-induced cytotoxicity of neural stem cells., Neurochem. Res.
    Konturek et al., 2003, Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients., Dig. Dis. Sci.
  • ERBITUX   BAX

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12850474


    Sources:
    NCI

  • O-CHLOROACETYLCARBAMOYLFUMAGILLOL   BAX

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10481942


    Sources:
    NCI

  • CILMOSTIM   BAX

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10770207


    Sources:
    NCI

  • PROCARBAZINE   BAX

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11839668


    Sources:
    NCI

  • CIPROFLOXACIN   BAX

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12632069 10741713


    Sources:
    NCI

  • BICALUTAMIDE   BAX

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11845989


    Sources:
    NCI

  • ROFECOXIB   BAX

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14627349


    Sources:
    NCI

  • KERACYANIN   BAX

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17360708


    Sources:
    DTC

  • SULFORAPHANE   BAX

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15753404


    Sources:
    NCI

  • NALTREXONE   BAX

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16716514


    Sources:
    NCI

  • ANDROSTENEDIONE   BAX

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15590985


    Sources:
    NCI

  • OXYTOCIN   BAX

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15590985


    Sources:
    NCI

  • ESTRAMUSTINE   BAX

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15869997


    Sources:
    NCI

  • BCG VACCINE   BAX

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9393826


    Sources:
    NCI

  • CARVEDILOL   BAX

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16759520 12973927


    Sources:
    NCI

  • DACARBAZINE   BAX

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14512787


    Sources:
    NCI

  • RETINOL   BAX

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17202653


    Sources:
    NCI

  • SODIUM CHLORIDE   BAX

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15641688


    Sources:
    NCI

  • MEDROXYPROGESTERONE ACETATE   BAX

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15885761


    Sources:
    NCI

  • PHENYLEPHRINE   BAX

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10220693


    Sources:
    NCI

  • PRASTERONE   BAX

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9177459


    Sources:
    NCI

  • ERYTHROMYCIN   BAX

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17007374


    Sources:
    NCI

  • FLUDARABINE   BAX

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12040435


    Sources:
    NCI

  • ANDROSTANOLONE   BAX

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15517879


    Sources:
    NCI

  • OXALIPLATIN   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15545975 14985457


    Sources:
    NCI

  • PREDNISOLONE   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12730678


    Sources:
    NCI

  • VINORELBINE   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11720482


    Sources:
    NCI

  • MELATONIN   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15205854


    Sources:
    NCI

  • LAPACHONE   BAX

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15753997


    Sources:
    NCI

  • MITOXANTRONE   BAX

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14767525 11839668


    Sources:
    NCI

  • LEUCOVORIN   BAX

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11237386


    Sources:
    NCI

  • ATENOLOL   BAX

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16995309


    Sources:
    NCI

  • VERAPAMIL   BAX

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9354939


    Sources:
    NCI

  • PRAVASTATIN   BAX

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16540096


    Sources:
    NCI

  • LEVODOPA   BAX

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15672541


    Sources:
    NCI

  • CAMPTOTHECIN   BAX

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9398050


    Sources:
    NCI

  • PHENOBARBITAL   BAX

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9230198


    Sources:
    NCI

  • NICOTINE   BAX

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15225679


    Sources:
    NCI

  • ETOPOSIDE   BAX

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15454884


    Sources:
    NCI

  • SIROLIMUS   BAX

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15782132


    Sources:
    NCI

  • DOCETAXEL   BAX

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15641988


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   BAX

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14767525


    Sources:
    NCI

  • QUERCETIN   BAX

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15741050


    Sources:
    NCI

  • DOXORUBICIN   BAX

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12040435


    Sources:
    NCI

  • FLUOROURACIL   BAX

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15641988


    Sources:
    NCI

  • METHOTREXATE   BAX

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11237386


    Sources:
    NCI

  • CISPLATIN   BAX

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15790433


    Sources:
    NCI

  • BORTEZOMIB   BAX

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • Ensembl: ENSG00000087088

    • Version: 101_38

    Alternate Names:
    BAX Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000087088

    • Version: 26-July-2011

    Alternate Names:
    BAX Display Id
    ENSG00000087088 Ensembl Gene Id
    BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07815] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q07812

    • Version: 11-September-2012

    Alternate Names:
    BAX Uniprot Gene Name
    BAX_HUMAN Uniprot Id
    ENSG00000087088 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Bcl2_BH
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: BAX

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Paradiso et al., 2001, Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer., Br. J. Cancer
    Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
    Bosanquet et al., 2002, Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia., Leukemia

  • DTC: BAX

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem

  • TALC: BAX

    • Version: 12-May-2016

    Alternate Names:
    BAX Gene Symbol

    Gene Info:

    Publications:

  • GO: BAX

    • Version: 01-February-2022

    Alternate Names:
    BCL2L4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21