DGIdb - BAX Gene Record

BAX 581 Druggable Genome

Alternate Names:

581
BCL2 ASSOCIATED X, APOPTOSIS REGULATOR
BAX
BCL2L4
600040
959
ENSG00000087088
OTTHUMG00000160476
BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07815]
Q07812
APOPTOSIS REGULATOR BAX
BAX_HUMAN

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Bcl2_BH
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000712
Interpro Name	Apoptosis regulator, Bcl-2, BH
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
DRUGGABLE GENOME

Publications:

Paradiso et al., 2001, Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer., Br. J. Cancer
Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene
Bosanquet et al., 2002, Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia., Leukemia
Baghelai et al., 1999, Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis., J. Thorac. Cardiovasc. Surg.
Osanai et al., 1997, Phenobarbital causes apoptosis in conditionally immortalized mouse hepatocytes depending on deregulated c-myc expression: characterization of an unexpected effect., Cancer Res.
Wang et al., 1997, Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice., Cancer Lett.
Madarová et al., 2001, Androgen sensitivity related proteins in hormone-sensitive and hormone-insensitive prostate cancer cell lines treated by androgen antagonist bicalutamide., Neoplasma
Angelucci et al., Apoptosis-related gene expression affected by a GnRH analogue without induction of programmed cell death in LNCaP cells., Anticancer Res.
Onur et al., 2004, The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele., Urol. Res.
Choi et al., 2005, Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent., Cancer Res.
Vereide et al., 2005, Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone., Gynecol. Oncol.
Hida et al., 2004, Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis., J. Lab. Clin. Med.
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Kim et al., 2005, Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells., J. Nutr. Biochem.
Matsubara et al., 2000, Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells., J. Clin. Endocrinol. Metab.
Yang et al., 2006, [Beneficial effects of carvedilol on cardiomyocyte apoptosis and bcl-2/bax expression after acute myocardial infarction an experiment with rats]., Zhonghua Yi Xue Za Zhi
Zeng et al., 2003, Effects of carvedilol on cardiomyocyte apoptosis and gene expression in vivo after ischemia-reperfusion in rats., J. Huazhong Univ. Sci. Technol. Med. Sci.
Liu et al., 2001, Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells., Br. J. Cancer
Huang et al., 2003, Differential responses by pancreatic carcinoma cell lines to prolonged exposure to Erbitux (IMC-C225) anti-EGFR antibody., J. Surg. Res.
Arango et al., 2004, Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells., Br. J. Cancer
Hayward et al., 2004, Enhanced oxaliplatin-induced apoptosis following antisense Bcl-xl down-regulation is p53 and Bax dependent: Genetic evidence for specificity of the antisense effect., Mol. Cancer Ther.
Liu et al., 2004, Effects of L-tetrahydropalmatine on the expressions of bcl-2 and bax in rat after acute global cerebral ischemia and reperfusion., J. Huazhong Univ. Sci. Technol. Med. Sci.
Wuenschell et al., 2004, Nicotine-responsive genes in cultured embryonic mouse lung buds: interaction of nicotine and superoxide dismutase., Pharmacol. Res.
Serafin et al., Influence of p53 and bcl-2 on chemosensitivity in benign and malignant prostatic cell lines., Urol. Oncol.
Yamamoto et al., 1999, Synergistic action of apoptosis induced by eicosapentaenoic acid and TNP-470 on human breast cancer cells., Breast Cancer Res. Treat.
Yoo et al., 2007, The additive effects of minoxidil and retinol on human hair growth in vitro., Biol. Pharm. Bull.
Shchepotin et al., Apoptosis induced by hyperthermia and verapamil in vitro in a human colon cancer cell line., Int J Hyperthermia
Takemura et al., 2005, Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy., J. Oral Pathol. Med.
Xu et al., 2006, [Effect of erythromycin on apoptosis of epithelial cell in nasal polyps]., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Rassidakis et al., 2002, BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome., Clin. Cancer Res.
Tirado et al., 2005, Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity., Oncogene
Woo et al., 2005, Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity., Int. J. Oncol.
Klingler et al., 1997, Effects of mycobacteria on regulation of apoptosis in mononuclear phagocytes., Infect. Immun.
Aranha et al., 2003, Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis., Int. J. Oncol.
Aranha et al., 2000, Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line., Clin. Cancer Res.
Demyanets et al., 2006, Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro., Biochem. Pharmacol.
Chen et al., 2006, [Effects of atenolol and metoprolol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction in rats]., Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Sirotkin et al., 2004, Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A., J. Endocrinol.
San-Emeterio et al., 2006, Modulation of brain apoptosis-related proteins by the opioid antagonist naltrexone in mice., Neurosci. Lett.
Weller et al., 1997, Topoisomerase-I inhibitors for human malignant glioma: differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and beta-lapachone., Int. J. Cancer
Kobylinska et al., 2004, Determination of the in vivo effects of cladribine alone and its combination with cyclophosphamide or cyclophosphamide and mitoxantrone on Bax and Bcl-2 protein expression in B-CLL cells., Oncol. Rep.
Shibuya et al., 2003, Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins., Melanoma Res.
Lee et al., 2005, Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line., Gynecol. Oncol.
Liu et al., 2004, Neuroprotection by pergolide against levodopa-induced cytotoxicity of neural stem cells., Neurochem. Res.
Konturek et al., 2003, Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients., Dig. Dis. Sci.

ERBITUX BAX

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12850474

Sources:
NCI
O-CHLOROACETYLCARBAMOYLFUMAGILLOL BAX

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10481942

Sources:
NCI
CILMOSTIM BAX

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10770207

Sources:
NCI
PROCARBAZINE BAX

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11839668

Sources:
NCI
CIPROFLOXACIN BAX

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12632069 10741713

Sources:
NCI
BICALUTAMIDE BAX

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11845989

Sources:
NCI
ROFECOXIB BAX

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14627349

Sources:
NCI
KERACYANIN BAX

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360708

Sources:
DTC
SULFORAPHANE BAX

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753404

Sources:
NCI
NALTREXONE BAX

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16716514

Sources:
NCI
ANDROSTENEDIONE BAX

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590985

Sources:
NCI
OXYTOCIN BAX

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590985

Sources:
NCI
ESTRAMUSTINE BAX

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15869997

Sources:
NCI
BCG VACCINE BAX

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9393826

Sources:
NCI
CARVEDILOL BAX

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16759520 12973927

Sources:
NCI
DACARBAZINE BAX

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14512787

Sources:
NCI
RETINOL BAX

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17202653

Sources:
NCI
SODIUM CHLORIDE BAX

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15641688

Sources:
NCI
MEDROXYPROGESTERONE ACETATE BAX

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15885761

Sources:
NCI
PHENYLEPHRINE BAX

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10220693

Sources:
NCI
PRASTERONE BAX

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9177459

Sources:
NCI
ERYTHROMYCIN BAX

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17007374

Sources:
NCI
FLUDARABINE BAX

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12040435

Sources:
NCI
ANDROSTANOLONE BAX

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15517879

Sources:
NCI
OXALIPLATIN BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15545975 14985457

Sources:
NCI
PREDNISOLONE BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12730678

Sources:
NCI
VINORELBINE BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11720482

Sources:
NCI
MELATONIN BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15205854

Sources:
NCI
LAPACHONE BAX

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753997

Sources:
NCI
MITOXANTRONE BAX

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14767525 11839668

Sources:
NCI
LEUCOVORIN BAX

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11237386

Sources:
NCI
ATENOLOL BAX

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16995309

Sources:
NCI
VERAPAMIL BAX

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9354939

Sources:
NCI
PRAVASTATIN BAX

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16540096

Sources:
NCI
LEVODOPA BAX

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15672541

Sources:
NCI
CAMPTOTHECIN BAX

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9398050

Sources:
NCI
PHENOBARBITAL BAX

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9230198

Sources:
NCI
NICOTINE BAX

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15225679

Sources:
NCI
ETOPOSIDE BAX

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15454884

Sources:
NCI
SIROLIMUS BAX

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15782132

Sources:
NCI
DOCETAXEL BAX

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15641988

Sources:
NCI
CYCLOPHOSPHAMIDE BAX

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14767525

Sources:
NCI
QUERCETIN BAX

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15741050

Sources:
NCI
DOXORUBICIN BAX

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12040435

Sources:
NCI
FLUOROURACIL BAX

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15641988

Sources:
NCI
METHOTREXATE BAX

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11237386

Sources:
NCI
CISPLATIN BAX

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15790433

Sources:
NCI
BORTEZOMIB BAX

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Ensembl: ENSG00000087088
- Version: 101_38
Alternate Names:

BAX Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000087088
- Version: 26-July-2011
Alternate Names:

BAX Display Id

ENSG00000087088 Ensembl Gene Id

BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07815] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q07812
- Version: 11-September-2012
Alternate Names:

BAX Uniprot Gene Name

BAX_HUMAN Uniprot Id

ENSG00000087088 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name Bcl2_BH

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: BAX

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Paradiso et al., 2001, Expression of apoptosis-related markers and clinical outcome in patients with advanced colorectal cancer., Br. J. Cancer

Dewson et al., 2003, Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells., Oncogene

Bosanquet et al., 2002, Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia., Leukemia

DTC: BAX
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
TALC: BAX
- Version: 12-May-2016
Alternate Names:

BAX Gene Symbol

Gene Info:

Publications:
GO: BAX
- Version: 01-February-2022
Alternate Names:

BCL2L4 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:

BAX	Display Id
ENSG00000087088	Ensembl Gene Id
BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07815]	Description

BAX	Uniprot Gene Name
BAX_HUMAN	Uniprot Id
ENSG00000087088	Ensembl Gene Id

BAX Gene Record

BAX 581 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12850474

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10481942

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10770207

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11839668

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12632069 10741713

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11845989

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14627349

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17360708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15753404

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16716514

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590985

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590985

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15869997

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9393826

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16759520 12973927

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14512787

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17202653

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15641688

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
12850474

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10481942

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10770207

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11839668

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12632069 10741713

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11845989

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14627349

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17360708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15753404

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16716514

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15590985

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15590985

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15869997

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9393826

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16759520 12973927

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14512787

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17202653

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15641688

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15885761

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10220693

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9177459

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17007374

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12040435

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15517879

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15545975 14985457

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12730678

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11720482