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BDNF Gene Record

  • Summary
  • Interactions
  • Claims
  • BDNF 627 Druggable Genome

    Alternate Names:

    627
    BRAIN DERIVED NEUROTROPHIC FACTOR
    BDNF
    ANON2
    BULN2
    113505
    1033
    ENSG00000176697
    OTTHUMG00000178797
    brain-derived neurotrophic factor
    PA31891
    T93122

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Mannion et al., 1999, Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity., Proc. Natl. Acad. Sci. U.S.A.
    Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics
    Wick et al., 2004, Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity., J. Neurochem.
    Gao X et al., 2017, Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese., OMICS
    Iamjan SA et al., 2015, BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence., Pharmacogenomics
    Haerian BS, 2013, BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis., Pharmacogenomics
    Paskowitz et al., 2004, BDNF reduces the retinal toxicity of verteporfin photodynamic therapy., Invest. Ophthalmol. Vis. Sci.
    Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Rantamäki et al., 2006, The effects of acute and long-term lithium treatments on trkB neurotrophin receptor activation in the mouse hippocampus and anterior cingulate cortex., Neuropharmacology
    Matayoshi et al., 2005, Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat., J. Physiol. (Lond.)
    Pearse et al., 2005, A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival., Blood
    Joyce et al., 2004, Loss of D3 receptors in the zitter mutant rat is not reversed by L-dopa treatment., Exp. Neurol.
    Middlemas et al., 1999, Brain derived neurotrophic factor protects human neuroblastoma cells from DNA damaging agents., J. Neurooncol.
    Naert et al., 2006, Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats., Neuroscience
    Viviani et al., 2005, Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor., J. Neurochem.
    Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
    Roy et al., 2007, Myelin basic protein-primed T cells induce neurotrophins in glial cells via alphavbeta3 [corrected] integrin., J. Biol. Chem.
    Wang et al., 2008, Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB., Brain Res.
    Xu et al., 2007, Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats., Brain Res.
    Nikolac Perkovic M et al., 2014, Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients., Psychopharmacology (Berl)
    Perroud N et al., 2009, Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project., Neuropsychopharmacology
    Duric et al., 2006, Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat., J. Pharmacol. Exp. Ther.
    Ramos et al., 2007, Diethylstilbestrol alters the population dynamic of neural precursor cells in the neonatal male rat dentate gyrus., Brain Res. Bull.
    Faron-Górecka et al., 2004, Long-term exposure of rats to tramadol alters brain dopamine and alpha 1-adrenoceptor function that may be related to antidepressant potency., Eur. J. Pharmacol.
    Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
    Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.
    Bozdagi et al., 2008, The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism., J. Neurosci.
    Lochner et al., 2008, Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity., Dev Neurobiol
    Kim et al., 2004, Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury., J. Korean Med. Sci.
    Yagasaki et al., 2006, Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release., J. Biol. Chem.
    Amino et al., 2002, Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca(2+)-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase., J. Biochem.
    Mizoguchi et al., 2006, BDNF occludes GABA receptor-mediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons., Eur. J. Neurosci.
    Van Hoomissen et al., 2003, Effects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in rat., Brain Res.
    Millan et al., 2004, S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: III. Actions in models of potential antidepressive and anxiolytic activity in comparison with ropinirole., J. Pharmacol. Exp. Ther.
    Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
    Serres et al., 2006, Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor., Brain Res.
    Pezet et al., 2002, BDNF modulates sensory neuron synaptic activity by a facilitation of GABA transmission in the dorsal horn., Mol. Cell. Neurosci.
    Hernández-Romero et al., 2008, Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide., J. Neurochem.
    Van Hoomissen et al., 2004, Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor., Behav. Neurosci.
    Kawamoto et al., 1996, Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain., Neuroscience
    Levran O et al., 2013, Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction., Pharmacogenomics
    de Cid et al., 2008, BDNF variability in opioid addicts and response to methadone treatment: preliminary findings., Genes Brain Behav.
    Zou YF et al., 2010, Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients., Neuropsychobiology
    Ono et al., 1997, Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice., Biochem. Biophys. Res. Commun.
    Ding et al., 2006, Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function., Neuroscience
    Wang P et al., 2018, Association of DNA methylation in BDNF with escitalopram treatment response in depressed Chinese Han patients., Eur J Clin Pharmacol
    Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
    Murphy GM Jr et al., 2013, BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression., Pharmacogenet Genomics
    Musil R et al., 2013, No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression., Eur Arch Psychiatry Clin Neurosci
    Yoshimura R et al., 2011, The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients., Prog Neuropsychopharmacol Biol Psychiatry
    Domschke K et al., 2010, Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response., Int J Neuropsychopharmacol
    Hetman et al., 1999, Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase., J. Biol. Chem.
    Mackin et al., 2007, Changes in brain-derived neurotrophic factor following treatment with mifepristone in bipolar disorder and schizophrenia., Aust N Z J Psychiatry
    Iijima et al., 2005, Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA., Proc. Natl. Acad. Sci. U.S.A.
    Mizoguchi et al., 2003, A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex., J. Biol. Chem.
    Zhu et al., 2007, Didanosine causes sensory neuropathy in an HIV/AIDS animal model: impaired mitochondrial and neurotrophic factor gene expression., Brain
    Butovsky et al., 2005, In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol., J. Neurochem.
    Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.
    Wu et al., 2006, Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma., Am. J. Pathol.
    Li et al., 2007, Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death., Cell Death Differ.
    Poulsen et al., 2004, Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry., Neuroscience
    Wang et al., 2006, Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling., J. Neurochem.
    Vaidya et al., 2001, Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression., Neuropharmacology
    Leingärtner et al., 1994, Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons., J. Biol. Chem.
    Pozzo-Miller, 2006, BDNF enhances dendritic Ca2+ signals evoked by coincident EPSPs and back-propagating action potentials in CA1 pyramidal neurons., Brain Res.
    Leyhe et al., 2008, Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease., Eur Arch Psychiatry Clin Neurosci
    Chlan-Fourney et al., 2002, Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration., Brain Res.
    Popper et al., 1999, Expression of BDNF and TrkB mRNAs in the crista neurosensory epithelium and vestibular ganglia following ototoxic damage., Brain Res.
    Mustafa et al., 2008, 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus., Eur. J. Neurosci.
  • K-252A   BDNF

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16797499


    Sources:
    NCI

  • VERTEPORFIN   BDNF

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15505074


    Sources:
    NCI

  • NYSTATIN   BDNF

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12941963


    Sources:
    NCI

  • THYROGLOBULIN   BDNF

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8895887


    Sources:
    NCI

  • FLURBIPROFEN   BDNF

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16531049


    Sources:
    NCI

  • PAROXETINE   BDNF

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29748862 23733030 23619509 22965830 21338649 20016225 19236730


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   BDNF

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28692418 26401760 24279859


    Sources:
    PharmGKB

  • DONEPEZIL   BDNF

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17990049


    Sources:
    NCI

  • DRONABINOL   BDNF

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15857384


    Sources:
    NCI

  • CITALOPRAM   BDNF

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29748862 23733030 23619509 22965830 21338649 20016225 19236730


    Sources:
    PharmGKB

  • GLUCAGON   BDNF

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17924870


    Sources:
    NCI

  • IONOMYCIN   BDNF

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12038986


    Sources:
    NCI

  • CORTICOTROPIN   BDNF

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330021


    Sources:
    NCI

  • BACLOFEN   BDNF

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17074039


    Sources:
    NCI

  • GEMFIBROZIL   BDNF

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17823123


    Sources:
    NCI

  • METYROSINE   BDNF

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16390493


    Sources:
    NCI

  • NALOXONE   BDNF

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12359151


    Sources:
    NCI

  • IMIPRAMINE   BDNF

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16522641


    Sources:
    NCI

  • NORTRIPTYLINE   BDNF

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19641488


    Sources:
    PharmGKB

  • DIDANOSINE   BDNF

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17616550


    Sources:
    NCI

  • ALTEPLASE   BDNF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18815270 18563704


    Sources:
    NCI

  • PILOCARPINE   BDNF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15183516


    Sources:
    NCI

  • METHAMPHETAMINE   BDNF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28692418 26401760 24279859


    Sources:
    PharmGKB

  • INOSITOL   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16286649


    Sources:
    NCI

  • METHADONE   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23651024 18182069


    Sources:
    NCI PharmGKB

  • SODIUM CHLORIDE   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12742641


    Sources:
    NCI

  • SUMATRIPTAN   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25096645


    Sources:
    PharmGKB

  • EPOETIN BETA   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15816864


    Sources:
    NCI

  • NICARDIPINE   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10748141


    Sources:
    NCI

  • VENLAFAXINE   BDNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14978196


    Sources:
    NCI

  • METHYLPREDNISOLONE   BDNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14966352


    Sources:
    NCI

  • TOPOTECAN   BDNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15569250


    Sources:
    NCI

  • CAPSAICIN   BDNF

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10430952


    Sources:
    NCI

  • PROPRANOLOL   BDNF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15598146


    Sources:
    NCI

  • VASOPRESSIN   BDNF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16457953


    Sources:
    NCI

  • LIDOCAINE   BDNF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16210356


    Sources:
    NCI

  • PROPYLTHIOURACIL   BDNF

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11077070


    Sources:
    NCI

  • TRAMADOL   BDNF

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15464068


    Sources:
    NCI

  • ESCITALOPRAM   BDNF

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19641488


    Sources:
    PharmGKB

  • MIFEPRISTONE   BDNF

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17464718


    Sources:
    NCI

  • GENTAMICIN   BDNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10536212


    Sources:
    NCI

  • CHLORPROMAZINE   BDNF

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18408624


    Sources:
    NCI

  • LITHIUM   BDNF

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24885933 16300803


    Sources:
    NCI PharmGKB

  • TROGLITAZONE   BDNF

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17924870


    Sources:
    NCI

  • FLUOXETINE   BDNF

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20016225


    Sources:
    PharmGKB

  • DIETHYLSTILBESTROL   BDNF

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17292805


    Sources:
    NCI

  • DESIPRAMINE   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LIOTHYRONINE SODIUM   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8288635


    Sources:
    NCI

  • INSULIN   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9299565 16650607


    Sources:
    NCI

  • INDOMETHACIN   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16956981


    Sources:
    NCI

  • CAMPTOTHECIN   BDNF

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10428835


    Sources:
    NCI

  • LEVODOPA   BDNF

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15081599


    Sources:
    NCI

  • CETUXIMAB   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16651634


    Sources:
    NCI

  • COLCHICINE   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1946455


    Sources:
    NCI

  • CURCUMIN   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18420184 17617388


    Sources:
    NCI

  • NICOTINE   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16790237


    Sources:
    NCI

  • SIMVASTATIN   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18047562


    Sources:
    NCI

  • VINCRISTINE   BDNF

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15569250


    Sources:
    NCI

  • HALOPERIDOL   BDNF

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12393228


    Sources:
    NCI

  • OLANZAPINE   BDNF

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24595507


    Sources:
    PharmGKB

  • BORTEZOMIB   BDNF

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15657181


    Sources:
    NCI

  • DOXORUBICIN   BDNF

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10728907


    Sources:
    NCI

  • PACLITAXEL   BDNF

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16778834


    Sources:
    NCI

  • FLUOROURACIL   BDNF

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18702703


    Sources:
    NCI

  • Ensembl: ENSG00000176697

    • Version: 101_38

    Alternate Names:
    BDNF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: BDNF

    • Version: 18-August-2020

    Alternate Names:
    PA31891 PharmGKB ID

    Gene Info:

    Publications:
    Haerian BS, 2013, BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis., Pharmacogenomics
    Gao X et al., 2017, Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese., OMICS
    Iamjan SA et al., 2015, BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence., Pharmacogenomics

  • NCI: BDNF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Mannion et al., 1999, Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity., Proc. Natl. Acad. Sci. U.S.A.
    Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics
    Tabuchi et al., 2000, Differential activation of brain-derived neurotrophic factor gene promoters I and III by Ca2+ signals evoked via L-type voltage-dependent and N-methyl-D-aspartate receptor Ca2+ channels., J. Biol. Chem.

  • HingoraniCasas: ENSG00000176697

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000176697 Gene Symbol
    BDNF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Brain-derived neurotrophic factor

    • Version: 2020.06.01

    Alternate Names:
    BDNF TTD Gene Abbreviation
    T93122 TTD Target ID

    Gene Info:

    Publications:

  • GO: BDNF

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21