DGIdb - BRD3 Gene Record

BRD3 8019 Druggable GenomeClinically Actionable

Alternate Names:

8019
BROMODOMAIN CONTAINING 3
BRD3
ORFX
RING3L
601541
1104
ENSG00000169925
OTTHUMG00000021004
2725
Q15059
NP_031397
NM_007371
Bromodomain-containing protein 3
T42048

Gene Info:

GuideToPharmacology Gene Category Name	Bromodomain kinase (BRDK) family
GuideToPharmacology Gene Category ID	558
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

CHEMBL52030 BRD3

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ABBV-744 BRD3

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL2153434 BRD3

Interaction Score: 2.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

MOLIBRESIB BRD3

Interaction Score: 1.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD3.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

ESTAZOLAM BRD3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM BRD3

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD3

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM BRD3

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC

Ensembl: ENSG00000169925
- Version: 101_38
Alternate Names:

BRD3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 8019
- Version: 29-September-2020
Alternate Names:

1104 HUGO Gene ID

1104 HUGO Gene Symbol

bromodomain containing 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Bromodomain kinase (BRDK) family

GuideToPharmacology Gene Category ID 558

Gene Categories:

ENZYME

Publications:
DTC: BRD3
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
HingoraniCasas: ENSG00000169925
- Version: 31-May-2017
Alternate Names:

ENSG00000169925 Gene Symbol

BRD3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: BRD3
- Version: 03-September-2020
Alternate Names:

Bromodomain-containing protein 3 Gene Name

Q15059 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
dGene: BRD3
- Version: 27-Jun-2013
Alternate Names:

8019 Gene ID

ORFX dGene Synonym

RING3L dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Bromodomain-containing protein 3
- Version: 2020.06.01
Alternate Names:

BRD3 TTD Gene Abbreviation

T42048 TTD Target ID

Gene Info:

Publications:
CarisMolecularIntelligence: BRD3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD3.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

1104	HUGO Gene ID
1104	HUGO Gene Symbol
bromodomain containing 3	HUGO Gene Name

8019	Gene ID
ORFX	dGene Synonym
RING3L	dGene Synonym

BRD3 Gene Record

BRD3 8019 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD3. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Ensembl: ENSG00000169925

Alternate Names: BRD3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 8019

Alternate Names: 1104 HUGO Gene ID 1104 HUGO Gene Symbol bromodomain containing 3 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Bromodomain kinase (BRDK) family GuideToPharmacology Gene Category ID 558

Gene Categories: ENZYME

Publications:

DTC: BRD3

Alternate Names:

Gene Info:

Publications: Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

HingoraniCasas: ENSG00000169925

Alternate Names: ENSG00000169925 Gene Symbol BRD3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: BRD3

Alternate Names: Bromodomain-containing protein 3 Gene Name Q15059 UniProt ID

Gene Info:

Gene Categories: KINASE, TRANSCRIPTION FACTOR

Publications:

dGene: BRD3

Alternate Names: 8019 Gene ID ORFX dGene Synonym RING3L dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

TTD: Bromodomain-containing protein 3

Alternate Names: BRD3 TTD Gene Abbreviation T42048 TTD Target ID

Gene Info:

Publications:

CarisMolecularIntelligence: BRD3

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD3.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Alternate Names:

BRD3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

1104 HUGO Gene ID

1104 HUGO Gene Symbol

bromodomain containing 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Bromodomain kinase (BRDK) family

GuideToPharmacology Gene Category ID 558

Gene Categories:

ENZYME

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

Alternate Names:

ENSG00000169925 Gene Symbol

BRD3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Bromodomain-containing protein 3 Gene Name

Q15059 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Alternate Names:

8019 Gene ID

ORFX dGene Synonym

RING3L dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

BRD3 TTD Gene Abbreviation

T42048 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE