DGIdb - BRD4 Gene Record

BRD4 23476 Druggable GenomeClinically Actionable

Alternate Names:

23476
BROMODOMAIN CONTAINING 4
BRD4
CAP
HUNK1
HUNKI
MCAP
608749
13575
ENSG00000141867
OTTHUMG00000183252
1945
NM_058243
NP_490597
O60885
9588
Bromodomain-containing protein 4
T40556

Gene Info:

GuideToPharmacology Gene Category Name	Bromodomain kinase (BRDK) family
GuideToPharmacology Gene Category ID	558
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.
Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov
Zhao L et al., 2015, Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization., J Med Chem
Engleson et al., 2006, Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy., BMC Cancer

CHEMBL2017291 BRD4

Interaction Score: 6.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25559428

Sources:
DTC
BIRABRESIB BRD4

Interaction Score: 2.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26976114

Sources:
CIViC TTD
CHEMBL52030 BRD4

Interaction Score: 2.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
APABETALONE BRD4

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

MOLIBRESIB BRD4

Interaction Score: 1.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

MIVEBRESIB BRD4

Interaction Score: 1.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ABBV-744 BRD4

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

CHEMBL2153434 BRD4

Interaction Score: 1.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

AZD-5153 BRD4

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BI-2536 BRD4

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
FEDRATINIB BRD4

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ESTAZOLAM BRD4

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
TRIAZOLAM BRD4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
ALPRAZOLAM BRD4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
MIDAZOLAM BRD4

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22137933

Sources:
DTC
DOCETAXEL BRD4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16542442

Sources:
NCI
COLCHICINE BRD4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000141867
- Version: 101_38
Alternate Names:

BRD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 23476
- Version: 29-September-2020
Alternate Names:

13575 HUGO Gene ID

13575 HUGO Gene Symbol

bromodomain containing 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Bromodomain kinase (BRDK) family

GuideToPharmacology Gene Category ID 558

Gene Categories:

ENZYME

Publications:

CIViC: BRD4

Version: 14-September-2020

Alternate Names:

23476 Entrez Gene ID

9588 CIViC Gene ID

Gene Info:

Publications:

Filippakopoulos et al., 2010, Selective inhibition of BET bromodomains., Nature

Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov

NCI: BRD4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Nagashima et al., 2007, Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis., Mol. Hum. Reprod.

Engleson et al., 2006, Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy., BMC Cancer

DTC: BRD4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Zhao L et al., 2015, Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization., J Med Chem

Filippakopoulos et al., 2012, Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family., Bioorg. Med. Chem.

HingoraniCasas: ENSG00000141867
- Version: 31-May-2017
Alternate Names:

ENSG00000141867 Gene Symbol

BRD4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: BRD4
- Version: 03-September-2020
Alternate Names:

Bromodomain-containing protein 4 Gene Name

O60885 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
Tempus: BRD4
- Version: 11-November-2018
Alternate Names:

BRD4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: BRD4
- Version: 27-Jun-2013
Alternate Names:

23476 Gene ID

CAP dGene Synonym

HUNK1 dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
TTD: Bromodomain-containing protein 4
- Version: 2020.06.01
Alternate Names:

BRD4 TTD Gene Abbreviation

T40556 TTD Target ID

Gene Info:

Publications:
MskImpact: BRD4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: BRD4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: BRD4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Details of the Assay for Interaction	Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

13575	HUGO Gene ID
13575	HUGO Gene Symbol
bromodomain containing 4	HUGO Gene Name

BRD4 Gene Record

BRD4 23476 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25559428

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26976114

Sources: CIViC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22137933

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16542442

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Ensembl: ENSG00000141867

Alternate Names: BRD4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 23476

Alternate Names: 13575 HUGO Gene ID 13575 HUGO Gene Symbol bromodomain containing 4 HUGO Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
25559428

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26976114

Sources:
CIViC TTD

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Displacement of a tetra-acetylated histone H4 peptide from the tandem BET bromodomains of BRD4.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22137933

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16542442

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

BRD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

13575 HUGO Gene ID

13575 HUGO Gene Symbol

bromodomain containing 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Bromodomain kinase (BRDK) family

GuideToPharmacology Gene Category ID 558

Gene Categories:

ENZYME

Alternate Names:

23476 Entrez Gene ID

9588 CIViC Gene ID

Publications:

Filippakopoulos et al., 2010, Selective inhibition of BET bromodomains., Nature

Stathis A et al., 2016, Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628., Cancer Discov

Alternate Names:

ENSG00000141867 Gene Symbol

BRD4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Bromodomain-containing protein 4 Gene Name

O60885 UniProt ID

Gene Categories:

KINASE

Alternate Names:

BRD4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

23476 Gene ID

CAP dGene Synonym

HUNK1 dGene Synonym

Gene Categories:

SERINE THREONINE KINASE, KINASE

Alternate Names:

BRD4 TTD Gene Abbreviation

T40556 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE