• Interaction Score: 20.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ziconotide,Prialt
    Novel drug target Established target

  • Interaction Score: 6.83

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name CNV2197944
    Novel drug target Established target
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker

    PMIDs:
    None found


  • Interaction Score: 2.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    25336921


    Sources:
    TTD

  • Interaction Score: 1.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

  • Interaction Score: 1.3

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker
    Direct Interaction yes
    Trial Name levetiracetam ,Keppra, Keppra XR

  • Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Trial Name Depomed

  • Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated N-type calcium channel alpha-1B subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes
    Trial Name XP13512

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Safinamide

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    CACNA1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CACNA1B Display Id
    ENSG00000148408 Ensembl Gene Id
    VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL ALPHA-1B SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV2.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE ISOFORM 5) (BRAIN CALCIUM CHANNEL III) (BIII). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00975] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    CACNA1B Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    CACNA1B Gene Symbol
    CAC1B_HUMAN Uniprot Id
    774 Entrez Gene Id

    Gene Info:
    Target Subclass Channels
    Target Subclass CalciumChannels
    Transmembrane Helix Count 22

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B Uniprot Protein Name
    CAC1B_HUMAN Uniprot Id
    Q00975 Uniprot Accession

    Gene Info:
    Human Readable Name ION CHANNEL
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    774 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav2.2
    Counted Citations from 1950-2000 290

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1389 HUGO Gene ID
    1389 HUGO Gene Symbol
    calcium voltage-gated channel subunit alpha1 B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000148408 Gene Symbol
    CACNA1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    CACNL1A5 GENE_SYMBOL
    CACNA1B GENE_SYMBOL
    Voltage-dependent N-type calcium channel subunit alpha-1B UNIPROT

    Gene Info:

    Publications:

  • Alternate Names:
    CACNA1B TTD Gene Abbreviation
    T38338 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Voltage-dependent N-type calcium channel subunit alpha-1B Gene Name
    Q00975 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications: