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CACNA1C Gene Record

  • Summary
  • Interactions
  • Claims
  • CACNA1C 775 Druggable Genome

    Alternate Names:

    775
    CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 C
    CACNA1C
    CACH2
    CACN2
    CACNL1A1
    CCHL1A1
    CaV1.2
    LQT8
    TS
    114205
    1390
    ENSG00000151067
    OTTHUMG00000150243
    Voltage-gated calcium channel subunit alpha Cav1.2
    Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
    Voltage-dependent L-type calcium channel subunit alpha-1C
    Q13936
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936]
    CAC1C_HUMAN
    PA83
    Voltage-gated calcium channel alpha Cav1.2
    T51115
    TS. LQT8

    Gene Info:

    Initial Gene Query Cav1.2
    Counted Citations from 1950-2000 1217
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name ION CHANNEL
    Interpro Acc IPR005821
    Target Main Class Transporters
    Target Subclass CalciumChannels
    Target Subclass Voltage_gated_ion_channels
    Transmembrane Helix Count 22
    Target Subclass Channels
    Target Class Transporters
    Target Subclass TC:1.A.1.11.4
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
    Morel et al., 1998, The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits., Br. J. Pharmacol.
    Dilmac et al., 2004, Molecular determinants of frequency dependence and Ca2+ potentiation of verapamil block in the pore region of Cav1.2., Mol. Pharmacol.
    Patel et al., 2005, Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells., Br. J. Pharmacol.
    Beitelshees AL et al., 2009, CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response., Circ Cardiovasc Genet
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hendricson et al., 2003, Suppression of L-type voltage-gated calcium channel-dependent synaptic plasticity by ethanol: analysis of miniature synaptic currents and dendritic calcium transients., J. Pharmacol. Exp. Ther.
    Mosheva M et al., 2020, Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder., J Affect Disord
    Berjukow et al., 2000, Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation., J. Biol. Chem.
    Zühlke et al., 1998, Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene., FEBS Lett.
    Hitzl et al., 2002, A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site., FEBS Lett.
    Nordlander et al., 2004, Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control., Cardiovasc Drug Rev
    Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
    Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
    Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
    Zhao Y et al., 2009, Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort., Eur J Clin Pharmacol
    Kim et al., 2009, Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage., J Korean Neurosurg Soc
    Weant et al., 2010, Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage., Pharmacotherapy
    Keyrouz et al., 2007, Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage., Crit Care
    Marchetti et al., 1996, High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons., Neurosci. Lett.
    Dong et al., 2010, Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking., Invest. Ophthalmol. Vis. Sci.
    Kumar et al., 2010, L-type calcium channel blockers, morphine and pain: Newer insights., Indian J Anaesth
    Baek MY et al., 2017, Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients., Eur J Clin Pharmacol
    Hu et al., 1998, Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties., Mol. Pharmacol.
    Wei et al., 1995, Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding., J. Biol. Chem.
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
    Doggrell et al., 2005, Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation., Expert Opin Investig Drugs
    Foster et al., 1997, Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation., Drugs
    Tang L et al., 2016, Structural basis for inhibition of a voltage-gated Ca<sup>2+</sup> channel by Ca<sup>2+</sup> antagonist drugs., Nature
    Bodi I et al., 2005, The L-type calcium channel in the heart: the beat goes on., J Clin Invest
    Casamassima F et al., 2010, Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder., Am J Med Genet B Neuropsychiatr Genet
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
  • IBUTILIDE   CACNA1C

    Interaction Score: 1.99

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    15926871 11752352 9257085


    Sources:
    TdgClinicalTrial TEND

  • RITODRINE   CACNA1C

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28391406


    Sources:
    PharmGKB

  • ISRADIPINE   CACNA1C

    Interaction Score: 1.71

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Trial Name -

    PMIDs:
    10766758 9607315 12135765


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • NIMODIPINE   CACNA1C

    Interaction Score: 1.33

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350


    Sources:
    ChemblInteractions PharmGKB

  • CLEVIDIPINE   CACNA1C

    Interaction Score: 1.0

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes
    Trial Name Clevelox

    PMIDs:
    15492770


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FELODIPINE   CACNA1C

    Interaction Score: 0.77

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

    PMIDs:
    17475903 10525060 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions

  • AMLODIPINE   CACNA1C

    Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name aliskiren + amlodipine,Tekamlo
    Novel drug target Established target
    Trial Name amlodipine besylate,Norvasc

    PMIDs:
    11752352 27556947 16322774


    Sources:
    TdgClinicalTrial

  • NISOLDIPINE   CACNA1C

    Interaction Score: 0.66

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    9584217 9846638 11752352 7592963


    Sources:
    ChemblInteractions

  • DILTIAZEM MALATE   CACNA1C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE MALEATE   CACNA1C

    Interaction Score: 0.5

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERAPAMIL   CACNA1C

    Interaction Score: 0.47

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Verapamil,Calan, Covera-HS
    Novel drug target Established target

    PMIDs:
    19125880 9846638 15286207 15880143 20031608


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • NICARDIPINE   CACNA1C

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial TEND

  • DILTIAZEM HYDROCHLORIDE   CACNA1C

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE BESYLATE   CACNA1C

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD1305   CACNA1C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERAPAMIL HYDROCHLORIDE   CACNA1C

    Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ELPETRIGINE   CACNA1C

    Interaction Score: 0.25

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NICARDIPINE HYDROCHLORIDE   CACNA1C

    Interaction Score: 0.22

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NIFEDIPINE   CACNA1C

    Interaction Score: 0.17

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    9846638 11752352 19029287


    Sources:
    ChemblInteractions

  • DRONEDARONE HYDROCHLORIDE   CACNA1C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CITALOPRAM   CACNA1C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19388002


    Sources:
    PharmGKB

  • ATENOLOL   CACNA1C

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20031608


    Sources:
    PharmGKB

  • GABAPENTIN ENACARBIL   CACNA1C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREGABALIN   CACNA1C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BEPRIDIL HYDROCHLORIDE   CACNA1C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ATAGABALIN   CACNA1C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IMAGABALIN   CACNA1C

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GABAPENTIN   CACNA1C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALCOHOL   CACNA1C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12970385 31634677


    Sources:
    PharmGKB

  • CELECOXIB   CACNA1C

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • HALOPERIDOL   CACNA1C

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27023437


    Sources:
    PharmGKB

  • Ensembl: ENSG00000151067

    • Version: 101_38

    Alternate Names:
    CACNA1C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: CACNA1C

    • Version: February-2014

    Alternate Names:
    775 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav1.2
    Counted Citations from 1950-2000 1217

    Gene Categories:
    ION CHANNEL

    Publications:

  • RussLampel: ENSG00000151067

    • Version: 26-July-2011

    Alternate Names:
    CACNA1C Display Id
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936] Description
    ENSG00000151067 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: Q13936

    • Version: 01-August-2011

    Alternate Names:
    775 Entrez Gene Id
    Q13936 Uniprot Accession
    CAC1C_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Transporters
    Target Subclass CalciumChannels
    Target Subclass Voltage_gated_ion_channels

    Publications:

  • HopkinsGroom: Q13936

    • Version: 11-September-2012

    Alternate Names:
    CAC1C_HUMAN Uniprot Id
    775 Entrez Gene Id
    CACNA1C Uniprot Gene Name

    Gene Info:
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    Interpro Type Domain

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q13936

    • Version: January-2014

    Alternate Names:
    CACNA1C Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11.4

    Publications:

  • PharmGKB: CACNA1C

    • Version: 18-August-2020

    Alternate Names:
    PA83 PharmGKB ID

    Gene Info:

    Publications:
    Casamassima F et al., 2010, Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder., Am J Med Genet B Neuropsychiatr Genet
    Bremer T et al., 2006, CACNA1C polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension., Pharmacogenomics
    Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

  • HingoraniCasas: ENSG00000151067

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000151067 Gene Symbol
    CACNA1C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CACH2

    • Version: chembl_23

    Alternate Names:
    CACN2 GENE_SYMBOL
    CACNL1A1 GENE_SYMBOL
    CCHL1A1 GENE_SYMBOL

    Gene Info:

    Publications:

  • TTD: Voltage-gated calcium channel alpha Cav1.2

    • Version: 2020.06.01

    Alternate Names:
    CACNA1C TTD Gene Abbreviation
    T51115 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CACNA1C

    • Version: 01-February-2022

    Alternate Names:
    Voltage-dependent L-type calcium channel subunit alpha-1C Gene Name
    Q13936 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21