DGIdb - CACNA1C Gene Record

CACNA1C 775 Druggable Genome

Alternate Names:

775
CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 C
CACNA1C
CACH2
CACN2
CACNL1A1
CCHL1A1
CaV1.2
LQT8
TS
114205
1390
ENSG00000151067
OTTHUMG00000150243
Voltage-gated calcium channel subunit alpha Cav1.2
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle
Voltage-dependent L-type calcium channel subunit alpha-1C
Q13936
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936]
CAC1C_HUMAN
PA83
Voltage-gated calcium channel alpha Cav1.2
T51115
TS. LQT8

Gene Info:

Initial Gene Query	Cav1.2
Counted Citations from 1950-2000	1217
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Interpro Name	Ion transport domain
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Human Readable Name	ION CHANNEL
Interpro Acc	IPR005821
Target Main Class	Transporters
Target Subclass	CalciumChannels
Target Subclass	Voltage_gated_ion_channels
Transmembrane Helix Count	22
Target Subclass	Channels
Target Class	Transporters
Target Subclass	TC:1.A.1.11.4
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
Morel et al., 1998, The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits., Br. J. Pharmacol.
Dilmac et al., 2004, Molecular determinants of frequency dependence and Ca2+ potentiation of verapamil block in the pore region of Cav1.2., Mol. Pharmacol.
Patel et al., 2005, Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells., Br. J. Pharmacol.
Beitelshees AL et al., 2009, CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response., Circ Cardiovasc Genet
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hendricson et al., 2003, Suppression of L-type voltage-gated calcium channel-dependent synaptic plasticity by ethanol: analysis of miniature synaptic currents and dendritic calcium transients., J. Pharmacol. Exp. Ther.
Mosheva M et al., 2020, Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder., J Affect Disord
Berjukow et al., 2000, Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation., J. Biol. Chem.
Zühlke et al., 1998, Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene., FEBS Lett.
Hitzl et al., 2002, A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site., FEBS Lett.
Nordlander et al., 2004, Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control., Cardiovasc Drug Rev
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
Zhao Y et al., 2009, Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort., Eur J Clin Pharmacol
Kim et al., 2009, Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage., J Korean Neurosurg Soc
Weant et al., 2010, Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage., Pharmacotherapy
Keyrouz et al., 2007, Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage., Crit Care
Marchetti et al., 1996, High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rat cerebellar granule neurons., Neurosci. Lett.
Dong et al., 2010, Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking., Invest. Ophthalmol. Vis. Sci.
Kumar et al., 2010, L-type calcium channel blockers, morphine and pain: Newer insights., Indian J Anaesth
Baek MY et al., 2017, Association between CACNA1C gene polymorphisms and ritodrine-induced adverse events in preterm labor patients., Eur J Clin Pharmacol
Hu et al., 1998, Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties., Mol. Pharmacol.
Wei et al., 1995, Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding., J. Biol. Chem.
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Doggrell et al., 2005, Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation., Expert Opin Investig Drugs
Foster et al., 1997, Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation., Drugs
Tang L et al., 2016, Structural basis for inhibition of a voltage-gated Ca<sup>2+</sup> channel by Ca<sup>2+</sup> antagonist drugs., Nature
Bodi I et al., 2005, The L-type calcium channel in the heart: the beat goes on., J Clin Invest
Casamassima F et al., 2010, Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder., Am J Med Genet B Neuropsychiatr Genet
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

IBUTILIDE CACNA1C

Interaction Score: 1.99

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15926871 11752352 9257085

Sources:
TdgClinicalTrial TEND
RITODRINE CACNA1C

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28391406

Sources:
PharmGKB
ISRADIPINE CACNA1C

Interaction Score: 1.71

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Trial Name -

PMIDs:
10766758 9607315 12135765

Sources:
TdgClinicalTrial ChemblInteractions TEND
NIMODIPINE CACNA1C

Interaction Score: 1.33

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources:
ChemblInteractions PharmGKB
CLEVIDIPINE CACNA1C

Interaction Score: 1.0

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name Clevelox

PMIDs:
15492770

Sources:
TdgClinicalTrial ChemblInteractions
FELODIPINE CACNA1C

Interaction Score: 0.77

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial ChemblInteractions
AMLODIPINE CACNA1C

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352 27556947 16322774

Sources:
TdgClinicalTrial
NISOLDIPINE CACNA1C

Interaction Score: 0.66

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9584217 9846638 11752352 7592963

Sources:
ChemblInteractions
DILTIAZEM MALATE CACNA1C

Interaction Score: 0.5

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE MALEATE CACNA1C

Interaction Score: 0.5

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERAPAMIL CACNA1C

Interaction Score: 0.47

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Verapamil,Calan, Covera-HS

Novel drug target Established target

PMIDs:
19125880 9846638 15286207 15880143 20031608

Sources:
TdgClinicalTrial TEND PharmGKB
NICARDIPINE CACNA1C

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND
DILTIAZEM HYDROCHLORIDE CACNA1C

Interaction Score: 0.4

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE BESYLATE CACNA1C

Interaction Score: 0.4

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD1305 CACNA1C

Interaction Score: 0.33

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERAPAMIL HYDROCHLORIDE CACNA1C

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
ELPETRIGINE CACNA1C

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NICARDIPINE HYDROCHLORIDE CACNA1C

Interaction Score: 0.22

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NIFEDIPINE CACNA1C

Interaction Score: 0.17

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9846638 11752352 19029287

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE CACNA1C

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CITALOPRAM CACNA1C

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19388002

Sources:
PharmGKB
ATENOLOL CACNA1C

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20031608

Sources:
PharmGKB
GABAPENTIN ENACARBIL CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
BEPRIDIL HYDROCHLORIDE CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ATAGABALIN CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
IMAGABALIN CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1C

Interaction Score: 0.07

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALCOHOL CACNA1C

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12970385 31634677

Sources:
PharmGKB
CELECOXIB CACNA1C

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
HALOPERIDOL CACNA1C

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023437

Sources:
PharmGKB

Ensembl: ENSG00000151067
- Version: 101_38
Alternate Names:

CACNA1C Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: CACNA1C
- Version: February-2014
Alternate Names:

775 Entrez Gene ID

Gene Info:

Initial Gene Query Cav1.2

Counted Citations from 1950-2000 1217

Gene Categories:

ION CHANNEL

Publications:

RussLampel: ENSG00000151067

Version: 26-July-2011

Alternate Names:

CACNA1C Display Id

VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936] Description

ENSG00000151067 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: Q13936
- Version: 01-August-2011
Alternate Names:

775 Entrez Gene Id

Q13936 Uniprot Accession

CAC1C_HUMAN Uniprot Id

Gene Info:

Target Main Class Transporters

Target Subclass CalciumChannels

Target Subclass Voltage_gated_ion_channels

Publications:
HopkinsGroom: Q13936
- Version: 11-September-2012
Alternate Names:

CAC1C_HUMAN Uniprot Id

775 Entrez Gene Id

CACNA1C Uniprot Gene Name

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Name Ion transport domain

Interpro Type Domain

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13936
- Version: January-2014
Alternate Names:

CACNA1C Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.11.4

Publications:

PharmGKB: CACNA1C

Version: 18-August-2020

Alternate Names:

PA83 PharmGKB ID

Gene Info:

Publications:

Casamassima F et al., 2010, Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder., Am J Med Genet B Neuropsychiatr Genet

Bremer T et al., 2006, CACNA1C polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension., Pharmacogenomics

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

HingoraniCasas: ENSG00000151067
- Version: 31-May-2017
Alternate Names:

ENSG00000151067 Gene Symbol

CACNA1C Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CACH2
- Version: chembl_23
Alternate Names:

CACN2 GENE_SYMBOL

CACNL1A1 GENE_SYMBOL

CCHL1A1 GENE_SYMBOL

Gene Info:

Publications:
TTD: Voltage-gated calcium channel alpha Cav1.2
- Version: 2020.06.01
Alternate Names:

CACNA1C TTD Gene Abbreviation

T51115 TTD Target ID

Gene Info:

Publications:
Pharos: CACNA1C
- Version: 01-February-2022
Alternate Names:

Voltage-dependent L-type calcium channel subunit alpha-1C Gene Name

Q13936 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated L-type calcium channel blocker
Trial Name	-

Trial Name	enalapril + felodipine,Lexxel
Novel drug target	Established target
Trial Name	felodipine ,Plendil

Trial Name	aliskiren + amlodipine,Tekamlo
Novel drug target	Established target
Trial Name	amlodipine besylate,Norvasc

Trial Name	Verapamil,Calan, Covera-HS
Novel drug target	Established target

Mechanism of Interaction	Voltage-gated calcium channel modulator
Direct Interaction	yes

Mechanism of Interaction	Voltage-gated calcium channel blocker
Direct Interaction	yes

CACNA1C	Display Id
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936]	Description
ENSG00000151067	Ensembl Gene Id

775	Entrez Gene Id
Q13936	Uniprot Accession
CAC1C_HUMAN	Uniprot Id

Voltage-dependent L-type calcium channel subunit alpha-1C	Gene Name
Q13936	UniProt ID

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

CACNA1C Gene Record

CACNA1C 775 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: activator (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15926871 11752352 9257085

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28391406

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker Trial Name -

PMIDs: 10766758 9607315 12135765

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes Trial Name Clevelox

PMIDs: 15492770

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

PMIDs: 17475903 10525060 11752352

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name aliskiren + amlodipine,Tekamlo Novel drug target Established target Trial Name amlodipine besylate,Norvasc

PMIDs: 11752352 27556947 16322774

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: 9584217 9846638 11752352 7592963

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name Verapamil,Calan, Covera-HS Novel drug target Established target

PMIDs: 19125880 9846638 15286207 15880143 20031608

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15926871 11752352 9257085

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
28391406

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Trial Name -

PMIDs:
10766758 9607315 12135765

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
19205682 19844625 20334460 17705883 8731425 11752352 20335610 20661350

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name Clevelox

PMIDs:
15492770

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352 27556947 16322774

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9584217 9846638 11752352 7592963

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Verapamil,Calan, Covera-HS

Novel drug target Established target

PMIDs:
19125880 9846638 15286207 15880143 20031608

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
9846638 11752352 19029287

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a