• Interaction Score: 2.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.4

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Ca<sub>v</sub>1.3 calcium channel complexes expressed in tsA201-cells
    Specific Action of the Ligand None
    Endogenous Drug? False

  • Interaction Score: 1.23

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name Clevelox
    Novel drug target Established target
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

  • Interaction Score: 1.07

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

  • Interaction Score: 0.92

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

  • Interaction Score: 0.49

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.49

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.41

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.35

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    19029287


  • Interaction Score: 0.31

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    CACNA1D Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D Uniprot Protein Name
    CAC1D_HUMAN Uniprot Id
    ENSG00000157388 Ensembl Gene Id

    Gene Info:
    Interpro Type Domain
    Interpro Name Ion transport domain
    Human Readable Name ION CHANNEL

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    CACNA1D Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000157388 Ensembl Gene Id
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1D SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.3) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01668] Description
    CACNA1D Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000157388 Ensembl Gene Id
    776 Entrez Gene Id
    CACNA1D Gene Symbol

    Gene Info:
    Target Subclass CalciumChannels
    Target Subclass Channels
    Transmembrane Helix Count 19

    Publications:

    • Version: February-2014

    Alternate Names:
    776 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav1.3
    Counted Citations from 1950-2000 463

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1391 HUGO Gene ID
    1391 HUGO Gene Symbol
    calcium voltage-gated channel subunit alpha1 D HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000157388 Gene Symbol
    CACNA1D Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    CACN4 GENE_SYMBOL
    CACNL1A2 GENE_SYMBOL
    CCHL1A2 GENE_SYMBOL

    Gene Info:

    Publications:

  • Alternate Names:
    CACNA1D TTD Gene Abbreviation
    T24793 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Voltage-dependent L-type calcium channel subunit alpha-1D Gene Name
    Q01668 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: