• Interaction Score: 1.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes
    Trial Name Clevelox

  • Interaction Score: 1.0

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.76

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.66

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.66

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.44

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Verapamil,Calan, Covera-HS
    Novel drug target Established target

    PMIDs:
    19125880


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    CACNA1F Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    CACNA1F Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11.11

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    O60840 Uniprot Accession
    CAC1F_HUMAN Uniprot Id
    CACNA1F Gene Symbol

    Gene Info:
    Target Main Class Transporters
    Target Subclass Voltage_gated_ion_channels
    Target Subclass Channels

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CAC1F_HUMAN Uniprot Id
    O60840 Uniprot Accession
    CACNA1F Uniprot Gene Name

    Gene Info:
    Interpro Short Name Ion_trans_dom
    Human Readable Name ION CHANNEL
    Interpro Type Domain

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    CACNA1F Display Id
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1F SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.4). [SOURCE:UNIPROT/SWISSPROT;ACC:O60840] Description
    ENSG00000102001 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: February-2014

    Alternate Names:
    778 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav1.4
    Counted Citations from 1950-2000 97

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1393 HUGO Gene ID
    1393 HUGO Gene Symbol
    calcium voltage-gated channel subunit alpha1 F HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: chembl_23

    Alternate Names:
    CACNAF1 GENE_SYMBOL
    CACNA1F GENE_SYMBOL
    Voltage-dependent L-type calcium channel subunit alpha-1F UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000102001 Gene Symbol
    CACNA1F Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Voltage-dependent L-type calcium channel subunit alpha-1F Gene Name
    O60840 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: