• Interaction Score: 6.38

    Interaction Types & Directionality:
    suppressor (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker

  • Interaction Score: 2.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

  • Interaction Score: 1.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Empatic
    Novel drug target Established target
    Trial Name OREX-003, olanzapine plus zonisamide SR

  • Interaction Score: 1.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker

    PMIDs:
    None found


  • Interaction Score: 1.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Pore blocker

    PMIDs:
    None found


  • Interaction Score: 0.94

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

  • Interaction Score: 0.8

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.64

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.46

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated T-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:


    Sources:
    TEND

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    CACNA1I Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000100346 Ensembl Gene Id
    VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL ALPHA-1I SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV3.3) (CA(V)3.3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9P0X4] Description
    CACNA1I Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    CACNA1I Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11.7

    Publications:

    • Version: February-2014

    Alternate Names:
    8911 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav3.3
    Counted Citations from 1950-2000 149

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    CACNA1I Uniprot Gene Name
    CAC1I_HUMAN Uniprot Id
    8911 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR005821
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ion_trans_dom

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000100346 Ensembl Gene Id
    8911 Entrez Gene Id
    Q9P0X4 Uniprot Accession

    Gene Info:
    Target Main Class Transporters
    Target Subclass Channels
    Transmembrane Helix Count 23

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1396 HUGO Gene ID
    1396 HUGO Gene Symbol
    calcium voltage-gated channel subunit alpha1 I HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated calcium channels
    GuideToPharmacology Gene Category ID 80

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100346 Gene Symbol
    CACNA1I Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    KIAA1120 GENE_SYMBOL
    CACNA1I GENE_SYMBOL
    Voltage-dependent T-type calcium channel subunit alpha-1I UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Voltage-dependent T-type calcium channel subunit alpha-1I Gene Name
    Q9P0X4 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: