DGIdb - CACNA1S Gene Record

CACNA1S 779 Druggable Genome

Alternate Names:

779
CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 S
CACNA1S
CACNL1A3
CCHL1A3
Cav1.1
HOKPP
HOKPP1
MHS5
TTPP1
hypoPP
114208
1397
ENSG00000081248
OTTHUMG00000035784
CACN1
Q13698
CAC1S_HUMAN
CACH1
Voltage-dependent L-type calcium channel subunit alpha-1S
Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle
Voltage-gated calcium channel subunit alpha Cav1.1
PA85
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1S SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.1) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 3, SKELETAL MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13698]

Gene Info:

Initial Gene Query	Cav1.1
Counted Citations from 1950-2000	275
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	ION CHANNEL
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR005821
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Interpro Short Name	Ion_trans_dom
Target Class	Transporters
Target Subclass	TC:1.A.1.11
Target Subclass	CalciumChannels
Target Subclass	Voltage_gated_ion_channels
Target Subclass	Channels
Transmembrane Helix Count	20
Target Main Class	Transporters
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Kim et al., 2009, Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage., J Korean Neurosurg Soc
Weant et al., 2010, Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage., Pharmacotherapy
Keyrouz et al., 2007, Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage., Crit Care
Dong et al., 2010, Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking., Invest. Ophthalmol. Vis. Sci.
Kumar et al., 2010, L-type calcium channel blockers, morphine and pain: Newer insights., Indian J Anaesth
Nordlander et al., 2004, Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control., Cardiovasc Drug Rev
Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
Monnier N et al., 2005, Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility., Hum Mutat
Weiss RG et al., 2004, Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling., Am J Physiol Cell Physiol
Monnier N et al., 2002, Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility., Anesthesiology
Stewart SL et al., 2001, Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia., Clin Genet
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

SUXAMETHONIUM CACNA1S

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
CLEVIDIPINE CACNA1S

Interaction Score: 1.0

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name Clevelox

PMIDs:
15492770

Sources:
TdgClinicalTrial ChemblInteractions
NIMODIPINE CACNA1S

Interaction Score: 0.93

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 16675661 20334460 17705883 20335610 20661350

Sources:
ChemblInteractions
ISRADIPINE CACNA1S

Interaction Score: 0.57

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions
DILTIAZEM MALATE CACNA1S

Interaction Score: 0.5

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE MALEATE CACNA1S

Interaction Score: 0.5

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FELODIPINE CACNA1S

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

PMIDs:
16675661

Sources:
TdgClinicalTrial ChemblInteractions
METHOXYFLURANE CACNA1S

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
DILTIAZEM HYDROCHLORIDE CACNA1S

Interaction Score: 0.4

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE BESYLATE CACNA1S

Interaction Score: 0.4

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOTHANE CACNA1S

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
ISOFLURANE CACNA1S

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
DESFLURANE CACNA1S

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
AZD1305 CACNA1S

Interaction Score: 0.33

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMLODIPINE CACNA1S

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amlodipine besylate,Norvasc

Novel drug target Established target

Trial Name Amturnide

PMIDs:
16675661

Sources:
TdgClinicalTrial
ENFLURANE CACNA1S

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
SEVOFLURANE CACNA1S

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB
VERAPAMIL HYDROCHLORIDE CACNA1S

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NISOLDIPINE CACNA1S

Interaction Score: 0.27

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions
ELPETRIGINE CACNA1S

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NICARDIPINE HYDROCHLORIDE CACNA1S

Interaction Score: 0.22

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERAPAMIL CACNA1S

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Verapamil,Calan, Covera-HS

Novel drug target Established target

PMIDs:
19125880

Sources:
TdgClinicalTrial TEND
DRONEDARONE HYDROCHLORIDE CACNA1S

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NIFEDIPINE CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
16675661

Sources:
ChemblInteractions
BEPRIDIL HYDROCHLORIDE CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
IMAGABALIN CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN ENACARBIL CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
ATAGABALIN CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1S

Interaction Score: 0.07

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CELECOXIB CACNA1S

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB

Ensembl: ENSG00000081248
- Version: 101_38
Alternate Names:

CACNA1S Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q13698
- Version: 11-September-2012
Alternate Names:

ENSG00000081248 Ensembl Gene Id

CACNA1S Uniprot Gene Name

CAC1S_HUMAN Uniprot Id

Gene Info:

Human Readable Name ION CHANNEL

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR005821

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13698
- Version: January-2014
Alternate Names:

CACNA1S Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.11

Publications:
TEND: Q13698
- Version: 01-August-2011
Alternate Names:

ENSG00000081248 Ensembl Gene Id

Q13698 Uniprot Accession

CACNA1S Gene Symbol

Gene Info:

Target Subclass CalciumChannels

Target Subclass Voltage_gated_ion_channels

Target Subclass Channels

Publications:
BaderLabGenes: CACNA1S
- Version: February-2014
Alternate Names:

779 Entrez Gene ID

Gene Info:

Initial Gene Query Cav1.1

Counted Citations from 1950-2000 275

Gene Categories:

ION CHANNEL

Publications:

RussLampel: ENSG00000081248

Version: 26-July-2011

Alternate Names:

ENSG00000081248 Ensembl Gene Id

CACNA1S Display Id

VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1S SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.1) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 3, SKELETAL MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13698] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: CACNA1S

Version: 18-August-2020

Alternate Names:

PA85 PharmGKB ID

Gene Info:

Publications:

Monnier N et al., 2005, Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility., Hum Mutat

Monnier N et al., 2002, Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility., Anesthesiology

Weiss RG et al., 2004, Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling., Am J Physiol Cell Physiol

HingoraniCasas: ENSG00000081248
- Version: 31-May-2017
Alternate Names:

ENSG00000081248 Gene Symbol

CACNA1S Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CACH1
- Version: chembl_23
Alternate Names:

CACN1 GENE_SYMBOL

CACNL1A3 GENE_SYMBOL

CACNA1S GENE_SYMBOL

Gene Info:

Publications:
Pharos: CACNA1S
- Version: 01-February-2022
Alternate Names:

Voltage-dependent L-type calcium channel subunit alpha-1S Gene Name

Q13698 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Voltage-gated L-type calcium channel blocker
Direct Interaction	yes
Trial Name	Clevelox

Trial Name	amlodipine besylate,Norvasc
Novel drug target	Established target
Trial Name	Amturnide

Trial Name	Verapamil,Calan, Covera-HS
Novel drug target	Established target

Mechanism of Interaction	Voltage-gated calcium channel blocker
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated calcium channel modulator

ENSG00000081248	Ensembl Gene Id
CACNA1S	Uniprot Gene Name
CAC1S_HUMAN	Uniprot Id

Voltage-dependent L-type calcium channel subunit alpha-1S	Gene Name
Q13698	UniProt ID

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

CACNA1S Gene Record

CACNA1S 779 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes Trial Name Clevelox

PMIDs: 15492770

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 19844625 16675661 20334460 17705883 20335610 20661350

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 16675661

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes Trial Name felodipine ,Plendil

PMIDs: 16675661

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name amlodipine besylate,Norvasc Novel drug target Established target Trial Name Amturnide

PMIDs: 16675661

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16163667 15201141 12411788 11260227

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name Clevelox

PMIDs:
15492770

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
19844625 16675661 20334460 17705883 20335610 20661350

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

PMIDs:
16675661

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amlodipine besylate,Norvasc

Novel drug target Established target

Trial Name Amturnide

PMIDs:
16675661

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16163667 15201141 12411788 11260227

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Verapamil,Calan, Covera-HS

Novel drug target Established target

PMIDs:
19125880