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CACNA1S Gene Record

  • Summary
  • Interactions
  • Claims
  • CACNA1S 779 Druggable Genome

    Alternate Names:

    779
    CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 S
    CACNA1S
    CACNL1A3
    CCHL1A3
    Cav1.1
    HOKPP
    HOKPP1
    MHS5
    TTPP1
    hypoPP
    114208
    1397
    ENSG00000081248
    OTTHUMG00000035784
    CACN1
    Q13698
    CAC1S_HUMAN
    CACH1
    Voltage-dependent L-type calcium channel subunit alpha-1S
    Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle
    Voltage-gated calcium channel subunit alpha Cav1.1
    PA85
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1S SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.1) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 3, SKELETAL MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13698]

    Gene Info:

    Initial Gene Query Cav1.1
    Counted Citations from 1950-2000 275
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name ION CHANNEL
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR005821
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Ion transport domain
    Interpro Short Name Ion_trans_dom
    Target Class Transporters
    Target Subclass TC:1.A.1.11
    Target Subclass CalciumChannels
    Target Subclass Voltage_gated_ion_channels
    Target Subclass Channels
    Transmembrane Helix Count 20
    Target Main Class Transporters
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
    Kim et al., 2009, Intraarterial nimodipine infusion to treat symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage., J Korean Neurosurg Soc
    Weant et al., 2010, Role of intraarterial therapy for cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage., Pharmacotherapy
    Keyrouz et al., 2007, Clinical review: Prevention and therapy of vasospasm in subarachnoid hemorrhage., Crit Care
    Dong et al., 2010, Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking., Invest. Ophthalmol. Vis. Sci.
    Kumar et al., 2010, L-type calcium channel blockers, morphine and pain: Newer insights., Indian J Anaesth
    Nordlander et al., 2004, Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control., Cardiovasc Drug Rev
    Tfelt-Hansen et al., 2009, Verapamil for cluster headache. Clinical pharmacology and possible mode of action., Headache
    Monnier N et al., 2005, Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility., Hum Mutat
    Weiss RG et al., 2004, Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling., Am J Physiol Cell Physiol
    Monnier N et al., 2002, Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility., Anesthesiology
    Stewart SL et al., 2001, Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia., Clin Genet
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
  • SUXAMETHONIUM   CACNA1S

    Interaction Score: 1.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • CLEVIDIPINE   CACNA1S

    Interaction Score: 1.0

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes
    Trial Name Clevelox

    PMIDs:
    15492770


    Sources:
    TdgClinicalTrial ChemblInteractions

  • NIMODIPINE   CACNA1S

    Interaction Score: 0.93

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    19844625 16675661 20334460 17705883 20335610 20661350


    Sources:
    ChemblInteractions

  • ISRADIPINE   CACNA1S

    Interaction Score: 0.57

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    16675661


    Sources:
    ChemblInteractions

  • DILTIAZEM MALATE   CACNA1S

    Interaction Score: 0.5

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE MALEATE   CACNA1S

    Interaction Score: 0.5

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FELODIPINE   CACNA1S

    Interaction Score: 0.46

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes
    Trial Name felodipine ,Plendil

    PMIDs:
    16675661


    Sources:
    TdgClinicalTrial ChemblInteractions

  • METHOXYFLURANE   CACNA1S

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • DILTIAZEM HYDROCHLORIDE   CACNA1S

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE BESYLATE   CACNA1S

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HALOTHANE   CACNA1S

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • ISOFLURANE   CACNA1S

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • DESFLURANE   CACNA1S

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • AZD1305   CACNA1S

    Interaction Score: 0.33

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMLODIPINE   CACNA1S

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name amlodipine besylate,Norvasc
    Novel drug target Established target
    Trial Name Amturnide

    PMIDs:
    16675661


    Sources:
    TdgClinicalTrial

  • ENFLURANE   CACNA1S

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • SEVOFLURANE   CACNA1S

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16163667 15201141 12411788 11260227


    Sources:
    PharmGKB

  • VERAPAMIL HYDROCHLORIDE   CACNA1S

    Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NISOLDIPINE   CACNA1S

    Interaction Score: 0.27

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    16675661


    Sources:
    ChemblInteractions

  • ELPETRIGINE   CACNA1S

    Interaction Score: 0.25

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NICARDIPINE HYDROCHLORIDE   CACNA1S

    Interaction Score: 0.22

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERAPAMIL   CACNA1S

    Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Verapamil,Calan, Covera-HS
    Novel drug target Established target

    PMIDs:
    19125880


    Sources:
    TdgClinicalTrial TEND

  • DRONEDARONE HYDROCHLORIDE   CACNA1S

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NIFEDIPINE   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker

    PMIDs:
    16675661


    Sources:
    ChemblInteractions

  • BEPRIDIL HYDROCHLORIDE   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PREGABALIN   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IMAGABALIN   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GABAPENTIN ENACARBIL   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Voltage-gated calcium channel modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ATAGABALIN   CACNA1S

    Interaction Score: 0.08

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GABAPENTIN   CACNA1S

    Interaction Score: 0.07

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Voltage-gated calcium channel modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CELECOXIB   CACNA1S

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • Ensembl: ENSG00000081248

    • Version: 101_38

    Alternate Names:
    CACNA1S Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q13698

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000081248 Ensembl Gene Id
    CACNA1S Uniprot Gene Name
    CAC1S_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name ION CHANNEL
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR005821

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q13698

    • Version: January-2014

    Alternate Names:
    CACNA1S Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.11

    Publications:

  • TEND: Q13698

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000081248 Ensembl Gene Id
    Q13698 Uniprot Accession
    CACNA1S Gene Symbol

    Gene Info:
    Target Subclass CalciumChannels
    Target Subclass Voltage_gated_ion_channels
    Target Subclass Channels

    Publications:

  • BaderLabGenes: CACNA1S

    • Version: February-2014

    Alternate Names:
    779 Entrez Gene ID

    Gene Info:
    Initial Gene Query Cav1.1
    Counted Citations from 1950-2000 275

    Gene Categories:
    ION CHANNEL

    Publications:

  • RussLampel: ENSG00000081248

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000081248 Ensembl Gene Id
    CACNA1S Display Id
    VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1S SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.1) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 3, SKELETAL MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13698] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CACNA1S

    • Version: 18-August-2020

    Alternate Names:
    PA85 PharmGKB ID

    Gene Info:

    Publications:
    Monnier N et al., 2005, Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility., Hum Mutat
    Monnier N et al., 2002, Presence of two different genetic traits in malignant hyperthermia families: implication for genetic analysis, diagnosis, and incidence of malignant hyperthermia susceptibility., Anesthesiology
    Weiss RG et al., 2004, Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling., Am J Physiol Cell Physiol

  • HingoraniCasas: ENSG00000081248

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000081248 Gene Symbol
    CACNA1S Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CACH1

    • Version: chembl_23

    Alternate Names:
    CACN1 GENE_SYMBOL
    CACNL1A3 GENE_SYMBOL
    CACNA1S GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: CACNA1S

    • Version: 01-February-2022

    Alternate Names:
    Voltage-dependent L-type calcium channel subunit alpha-1S Gene Name
    Q13698 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21