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CASP1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CASP1 834 Druggable Genome

    Alternate Names:

    834
    CASPASE 1
    CASP1
    ICE
    IL1BC
    P45
    147678
    1499
    ENSG00000137752
    OTTHUMG00000048072
    P29466
    CASPASE-1 SUBUNIT P20
    CASP1_HUMAN
    IL1BCE
    CASPASE-1 PRECURSOR (EC 3.4.22.36) (CASP-1) (INTERLEUKIN-1 BETA CONVERTASE) (IL-1BC) (IL-1 BETA CONVERTING ENZYME) (ICE) (INTERLEUKIN- 1 BETA CONVERTING ENZYME) (P45). [SOURCE:UNIPROT/SWISSPROT;ACC:P29466]
    IL-1 beta-converting enzyme
    IL-1BC
    CASP-1
    Interleukin-1 beta-converting enzyme
    Interleukin-1 beta convertase
    Caspase-1 subunit p10
    Caspase-1
    T98269

    Gene Info:

    Human Readable Name PROTEASE
    Interpro Acc IPR002398
    Interpro Name Peptidase C14, caspase precursor p45
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Pept_C14_p45
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.4.22.36
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
    Ross et al., 2007, A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat., Neuropharmacology
    Stierle AA et al., 2012, Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines., J Nat Prod
    Chen MH et al., 1999, An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9-(benzoylamino) octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1-yl]-carbonyl ]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor., Bioorg Med Chem Lett
    Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod
  • CHEMBL415893   CASP1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10386941


    Sources:
    DTC

  • VERMISTATIN   CASP1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22295871


    Sources:
    DTC

  • PRALNACASAN   CASP1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17845807


    Sources:
    TTD

  • BELNACASAN   CASP1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name VX-765
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • BERKELEYACETAL A   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYACETAL B   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYAMIDE B   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18330993


    Sources:
    DTC

  • BERKELEYAMIDE C   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18330993


    Sources:
    DTC

  • BERKELEYTRIONE   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYACETAL C   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • BERKELEYDIONE   CASP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17970594


    Sources:
    DTC

  • NIVOCASAN   CASP1

    Interaction Score: 1.79

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Caspase-1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ISOBOLDINE   CASP1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL337173   CASP1

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIACEREIN   CASP1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL580421   CASP1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EMRICASAN   CASP1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Caspase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MESALAMINE   CASP1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JUGLONE   CASP1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 4-CHLOROMERCURIBENZOIC ACID   CASP1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL578512   CASP1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GOSSYPOL   CASP1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL429095   CASP1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000137752

    • Version: 101_38

    Alternate Names:
    CASP1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000137752

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000137752 Ensembl Gene Id
    CASPASE-1 PRECURSOR (EC 3.4.22.36) (CASP-1) (INTERLEUKIN-1 BETA CONVERTASE) (IL-1BC) (IL-1 BETA CONVERTING ENZYME) (ICE) (INTERLEUKIN- 1 BETA CONVERTING ENZYME) (P45). [SOURCE:UNIPROT/SWISSPROT;ACC:P29466] Description
    CASP1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P29466

    • Version: January-2014

    Alternate Names:
    CASP1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.22.36

    Publications:

  • HopkinsGroom: P29466

    • Version: 11-September-2012

    Alternate Names:
    834 Entrez Gene Id
    CASP1 Uniprot Gene Name
    CASP1_HUMAN Uniprot Id

    Gene Info:
    Interpro Acc IPR002398
    Interpro Name Peptidase C14, caspase precursor p45
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • DTC: CASP1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Stierle DB et al., 2007, The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium., J Nat Prod
    Stierle AA et al., 2012, Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines., J Nat Prod
    Stierle AA et al., 2008, The berkeleyamides, amides from the acid lake fungus Penicillum rubrum., J Nat Prod

  • HingoraniCasas: ENSG00000137752

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137752 Gene Symbol
    CASP1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: IL1BC

    • Version: chembl_23

    Alternate Names:
    IL1BCE GENE_SYMBOL
    CASP1 GENE_SYMBOL
    Caspase-1 UNIPROT

    Gene Info:

    Publications:

  • dGene: CASP1

    • Version: 27-Jun-2013

    Alternate Names:
    834 Gene ID
    ICE dGene Synonym
    IL1BC dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Caspase-1

    • Version: 2020.06.01

    Alternate Names:
    CASP1 TTD Gene Abbreviation
    T98269 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CASP1

    • Version: 01-February-2022

    Alternate Names:
    Caspase-1 Gene Name
    P29466 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21