DGIdb - CASP3 Gene Record

CASP3 836 Druggable Genome

Alternate Names:

836
CASPASE 3
CASP3
CPP32
CPP32B
SCA-1
600636
1504
ENSG00000164305
OTTHUMG00000133681
Apopain
CPP-32
CASP-3
SREBP cleavage activity 1
Protein Yama
Cysteine protease CPP32
Caspase-3
Caspase-3 subunit p17
Caspase-3 subunit p12
P42574
PA26087
CASP3_HUMAN
CASPASE-3 PRECURSOR (EC 3.4.22.-) (CASP-3) (APOPAIN) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42574]
T57943

Gene Info:

Human Readable Name	PROTEASE
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Peptidase C14, caspase precursor p45
Interpro Acc	IPR002398
Interpro Type	Family
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Pept_C14_p45
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Goode DR et al., 2008, Identification of promiscuous small molecule activators in high-throughput enzyme activation screens., J Med Chem
Ibrado et al., 1997, Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells., Cancer Res.
Meli M et al., 2006, Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead., J Med Chem
Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
Kokel D et al., 2006, The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans., Nat Chem Biol
Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem
Lakshmi PJ et al., 2009, Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach., Bioorg Med Chem
Lee SR et al., 2007, Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells., Bioorg Med Chem Lett
Liu GY et al., 2007, 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways., J Nat Prod
Kok SH et al., 2008, Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines., Bioorg Med Chem
Peterson QP et al., 2009, Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3., J Med Chem
Putt et al., 2006, Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy., Nat. Chem. Biol.
Kawamura T et al., 2011, Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP., Bioorg Med Chem

TELEOCIDIN B CASP3

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21696964

Sources:
DTC
PHATHALIMIDE CASP3

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18295491

Sources:
DTC
KOBOPHENOL A CASP3

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17300930

Sources:
DTC
CHEMBL560532 CASP3

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19631549

Sources:
DTC
1,4-DICHLOROBENZENE CASP3

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16699520

Sources:
DTC
PAC-1 CASP3

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19708658 16936720

Sources:
DTC
CHEMBL376616 CASP3

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17088067

Sources:
DTC
CHEMBL483849 CASP3

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17181154

Sources:
DTC
CHEMBL375563 CASP3

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17261067

Sources:
DTC
NAPHTHOQUINONE CASP3

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16699520

Sources:
DTC
SPERMINE CASP3

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18366176

Sources:
DTC
CHEMBL378903 CASP3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
XANTHOANGELOL B CASP3

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL584668 CASP3

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL546865 CASP3

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
WITHAFERIN A CASP3

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705001

Sources:
DTC
CHEMBL546170 CASP3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL484663 CASP3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL412603 CASP3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1210769 CASP3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIACEREIN CASP3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL600313 CASP3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1493528 CASP3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL576208 CASP3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL312032 CASP3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMRICASAN CASP3

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Caspase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IPRIFLAVONE CASP3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1504679 CASP3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE CASP3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705001

Sources:
DTC
CHEMBL428789 CASP3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL299853 CASP3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB CASP3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
PACLITAXEL CASP3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9067280

Sources:
NCI

Ensembl: ENSG00000164305
- Version: 101_38
Alternate Names:

CASP3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000164305

Version: 26-July-2011

Alternate Names:

CASP3 Display Id

ENSG00000164305 Ensembl Gene Id

CASPASE-3 PRECURSOR (EC 3.4.22.-) (CASP-3) (APOPAIN) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42574] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P42574
- Version: 11-September-2012
Alternate Names:

CASPASE-3 SUBUNIT P17 Uniprot Protein Name

CASP3 Uniprot Gene Name

ENSG00000164305 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Peptidase C14, caspase precursor p45

Human Readable Name PROTEASE

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
PharmGKB: CASP3
- Version: 18-August-2020
Alternate Names:

PA26087 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

NCI: CASP3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ibrado et al., 1997, Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells., Cancer Res.

Tagami et al., Fas-mediated apoptosis in acute alcoholic hepatitis., Hepatogastroenterology

DTC: CASP3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Goode DR et al., 2008, Identification of promiscuous small molecule activators in high-throughput enzyme activation screens., J Med Chem

Meli M et al., 2006, Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead., J Med Chem

Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem

ChemblInteractions: CPP32
- Version: chembl_23
Alternate Names:

Protein Yama UNIPROT

CPP32 GENE_SYMBOL

CASP3 GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000164305
- Version: 31-May-2017
Alternate Names:

ENSG00000164305 Gene Symbol

CASP3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CASP3
- Version: 01-February-2022
Alternate Names:

CPP32 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
dGene: CASP3
- Version: 27-Jun-2013
Alternate Names:

836 Gene ID

CPP32 dGene Synonym

CPP32B dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Caspase-3
- Version: 2020.06.01
Alternate Names:

CASP3 TTD Gene Abbreviation

T57943 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: CASP3
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Caspase inhibitor
Direct Interaction	yes

CASP3	Display Id
ENSG00000164305	Ensembl Gene Id
CASPASE-3 PRECURSOR (EC 3.4.22.-) (CASP-3) (APOPAIN) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42574]	Description

CASPASE-3 SUBUNIT P17	Uniprot Protein Name
CASP3	Uniprot Gene Name
ENSG00000164305	Ensembl Gene Id

CASP3 Gene Record

CASP3 836 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21696964

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18295491

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17300930

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19631549

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16699520

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19708658 16936720

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17088067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17181154

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17261067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16699520

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18366176

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705001

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
21696964

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18295491

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17300930

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19631549

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16699520

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19708658 16936720

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17088067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17181154

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17261067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16699520

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18366176

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705001

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Caspase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a