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CASP3 Gene Record

  • Summary
  • Interactions
  • Claims
  • CASP3 836 Druggable Genome

    Alternate Names:

    836
    CASPASE 3
    CASP3
    CPP32
    CPP32B
    SCA-1
    600636
    1504
    ENSG00000164305
    OTTHUMG00000133681
    Apopain
    CPP-32
    CASP-3
    SREBP cleavage activity 1
    Protein Yama
    Cysteine protease CPP32
    Caspase-3
    Caspase-3 subunit p17
    Caspase-3 subunit p12
    P42574
    PA26087
    CASP3_HUMAN
    CASPASE-3 PRECURSOR (EC 3.4.22.-) (CASP-3) (APOPAIN) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42574]
    T57943

    Gene Info:

    Human Readable Name PROTEASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Peptidase C14, caspase precursor p45
    Interpro Acc IPR002398
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Pept_C14_p45
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Goode DR et al., 2008, Identification of promiscuous small molecule activators in high-throughput enzyme activation screens., J Med Chem
    Ibrado et al., 1997, Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells., Cancer Res.
    Meli M et al., 2006, Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead., J Med Chem
    Llanos GG et al., 2012, Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells., Eur J Med Chem
    Kokel D et al., 2006, The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans., Nat Chem Biol
    Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem
    Lakshmi PJ et al., 2009, Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach., Bioorg Med Chem
    Lee SR et al., 2007, Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells., Bioorg Med Chem Lett
    Liu GY et al., 2007, 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways., J Nat Prod
    Kok SH et al., 2008, Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines., Bioorg Med Chem
    Peterson QP et al., 2009, Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3., J Med Chem
    Putt et al., 2006, Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy., Nat. Chem. Biol.
    Kawamura T et al., 2011, Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP., Bioorg Med Chem
  • TELEOCIDIN B   CASP3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21696964


    Sources:
    DTC

  • PHATHALIMIDE   CASP3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18295491


    Sources:
    DTC

  • KOBOPHENOL A   CASP3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17300930


    Sources:
    DTC

  • CHEMBL560532   CASP3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19631549


    Sources:
    DTC

  • 1,4-DICHLOROBENZENE   CASP3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16699520


    Sources:
    DTC

  • PAC-1   CASP3

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19708658 16936720


    Sources:
    DTC

  • CHEMBL376616   CASP3

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17088067


    Sources:
    DTC

  • CHEMBL483849   CASP3

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17181154


    Sources:
    DTC

  • CHEMBL375563   CASP3

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17261067


    Sources:
    DTC

  • NAPHTHOQUINONE   CASP3

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16699520


    Sources:
    DTC

  • SPERMINE   CASP3

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18366176


    Sources:
    DTC

  • CHEMBL378903   CASP3

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • XANTHOANGELOL B   CASP3

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL584668   CASP3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL546865   CASP3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WITHAFERIN A   CASP3

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705001


    Sources:
    DTC

  • CHEMBL546170   CASP3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL484663   CASP3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL412603   CASP3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1210769   CASP3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIACEREIN   CASP3

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL600313   CASP3

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1493528   CASP3

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL576208   CASP3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL312032   CASP3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EMRICASAN   CASP3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Caspase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IPRIFLAVONE   CASP3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1504679   CASP3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • STAUROSPORINE   CASP3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705001


    Sources:
    DTC

  • CHEMBL428789   CASP3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL299853   CASP3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CELECOXIB   CASP3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • PACLITAXEL   CASP3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9067280


    Sources:
    NCI

  • Ensembl: ENSG00000164305

    • Version: 101_38

    Alternate Names:
    CASP3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000164305

    • Version: 26-July-2011

    Alternate Names:
    CASP3 Display Id
    ENSG00000164305 Ensembl Gene Id
    CASPASE-3 PRECURSOR (EC 3.4.22.-) (CASP-3) (APOPAIN) (CYSTEINE PROTEASE CPP32) (YAMA PROTEIN) (CPP-32) (SREBP CLEAVAGE ACTIVITY 1) (SCA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42574] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P42574

    • Version: 11-September-2012

    Alternate Names:
    CASPASE-3 SUBUNIT P17 Uniprot Protein Name
    CASP3 Uniprot Gene Name
    ENSG00000164305 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Peptidase C14, caspase precursor p45
    Human Readable Name PROTEASE

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: CASP3

    • Version: 18-August-2020

    Alternate Names:
    PA26087 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • NCI: CASP3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ibrado et al., 1997, Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells., Cancer Res.
    Tagami et al., Fas-mediated apoptosis in acute alcoholic hepatitis., Hepatogastroenterology

  • DTC: CASP3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Goode DR et al., 2008, Identification of promiscuous small molecule activators in high-throughput enzyme activation screens., J Med Chem
    Meli M et al., 2006, Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead., J Med Chem
    Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem

  • ChemblInteractions: CPP32

    • Version: chembl_23

    Alternate Names:
    Protein Yama UNIPROT
    CPP32 GENE_SYMBOL
    CASP3 GENE_SYMBOL

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000164305

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164305 Gene Symbol
    CASP3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CASP3

    • Version: 01-February-2022

    Alternate Names:
    CPP32 GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • dGene: CASP3

    • Version: 27-Jun-2013

    Alternate Names:
    836 Gene ID
    CPP32 dGene Synonym
    CPP32B dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Caspase-3

    • Version: 2020.06.01

    Alternate Names:
    CASP3 TTD Gene Abbreviation
    T57943 TTD Target ID

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: CASP3

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21