DGIdb - CASP7 Gene Record

CASP7 840 Druggable Genome

Alternate Names:

840
CASPASE 7
CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
601761
1508
ENSG00000165806
OTTHUMG00000019076
ICE-like apoptotic protease 3
Apoptotic protease Mch-3
Caspase-7 subunit p11
Caspase-7 subunit p20
Caspase-7
CASPASE-7 PRECURSOR (EC 3.4.22.-) (CASP-7) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (CMH-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55210]
P55210
CASP7_HUMAN
PA26091
T72252

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Name	Peptidase C14, caspase precursor p45
Human Readable Name	PROTEASE
Interpro Short Name	Pept_C14_p45
Interpro Acc	IPR002398
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Qian J et al., 2012, Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment., Chest
Liu GY et al., 2007, 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways., J Nat Prod
Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem

CHEMBL376616 CASP7

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17088067

Sources:
DTC
CHEMBL375563 CASP7

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17261067

Sources:
DTC
CHEMBL72410 CASP7

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROEMERINE CASP7

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL445304 CASP7

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL516616 CASP7

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BITHIONOLATE SODIUM CASP7

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1210769 CASP7

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMRICASAN CASP7

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Caspase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE CASP7

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22441531

Sources:
PharmGKB
STICTIC ACID CASP7

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1601846 CASP7

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BITHIONOL CASP7

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578512 CASP7

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PURPUROGALLIN CASP7

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOCETAXEL CASP7

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22441531

Sources:
PharmGKB
MYRICETIN CASP7

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEMCITABINE CASP7

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22441531

Sources:
PharmGKB
GOSSYPOL CASP7

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL CASP7

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22441531

Sources:
PharmGKB

Ensembl: ENSG00000165806
- Version: 101_38
Alternate Names:

CASP7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000165806

Version: 26-July-2011

Alternate Names:

CASP7 Display Id

CASPASE-7 PRECURSOR (EC 3.4.22.-) (CASP-7) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (CMH-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55210] Description

ENSG00000165806 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P55210
- Version: 11-September-2012
Alternate Names:

CASP7_HUMAN Uniprot Id

ENSG00000165806 Ensembl Gene Id

P55210 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Uniprot Status Swiss-Prot

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
PharmGKB: CASP7
- Version: 18-August-2020
Alternate Names:

PA26091 PharmGKB ID

Gene Info:

Publications:

Qian J et al., 2012, Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment., Chest

DTC: CASP7

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liu GY et al., 2007, 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways., J Nat Prod

Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem

ChemblInteractions: MCH3
- Version: chembl_23
Alternate Names:

MCH3 GENE_SYMBOL

CASP7 GENE_SYMBOL

Caspase-7 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000165806
- Version: 31-May-2017
Alternate Names:

ENSG00000165806 Gene Symbol

CASP7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CASP7
- Version: 01-February-2022
Alternate Names:

MCH3 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
dGene: CASP7
- Version: 27-Jun-2013
Alternate Names:

840 Gene ID

CASP-7 dGene Synonym

CMH-1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Caspase-7
- Version: 2020.06.01
Alternate Names:

CASP7 TTD Gene Abbreviation

T72252 TTD Target ID

Gene Info:

Publications:
Pharos: CASP7
- Version: 01-February-2022
Alternate Names:

Caspase-7 Gene Name

P55210 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Caspase inhibitor

CASP7	Display Id
CASPASE-7 PRECURSOR (EC 3.4.22.-) (CASP-7) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (CMH-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55210]	Description
ENSG00000165806	Ensembl Gene Id

CASP7_HUMAN	Uniprot Id
ENSG00000165806	Ensembl Gene Id
P55210	Uniprot Accession

CASP7 Gene Record

CASP7 840 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17088067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17261067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Caspase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22441531

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22441531

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22441531

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17088067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17261067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Caspase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22441531

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22441531

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22441531

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22441531

Sources:
PharmGKB

Alternate Names:

CASP7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CASP7 Display Id

CASPASE-7 PRECURSOR (EC 3.4.22.-) (CASP-7) (ICE-LIKE APOPTOTIC PROTEASE 3) (ICE-LAP3) (APOPTOTIC PROTEASE MCH-3) (CMH-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55210] Description

ENSG00000165806 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CASP7_HUMAN Uniprot Id

ENSG00000165806 Ensembl Gene Id

P55210 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Uniprot Status Swiss-Prot

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

PA26091 PharmGKB ID

Publications:

Qian J et al., 2012, Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment., Chest

Publications:

Liu GY et al., 2007, 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways., J Nat Prod

Vine KL et al., 2007, In vitro cytotoxicity evaluation of some substituted isatin derivatives., Bioorg Med Chem

Alternate Names:

MCH3 GENE_SYMBOL

CASP7 GENE_SYMBOL

Caspase-7 UNIPROT

Alternate Names:

ENSG00000165806 Gene Symbol

CASP7 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MCH3 GO Gene Synonym

Gene Categories:

PROTEASE

Alternate Names:

840 Gene ID

CASP-7 dGene Synonym

CMH-1 dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

CASP7 TTD Gene Abbreviation

T72252 TTD Target ID