DGIdb - CBR1 Gene Record

CBR1 873 Druggable Genome

Alternate Names:

873
CARBONYL REDUCTASE 1
CBR1
CBR
SDR21C1
hCBR1
114830
1548
ENSG00000159228
OTTHUMG00000086618
PA26121
CARBONYL REDUCTASE [NADPH] 1 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 1) (PROSTAGLANDIN-E(2) 9-REDUCTASE) (EC 1.1.1.189) (PROSTAGLANDIN 9-KETOREDUCTASE) (15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NADP+]) (EC 1.1.1.197). [SOURCE:UNIPROT/SWISSPROT;AC
P16152
CBR1_HUMAN
CARBONYL REDUCTASE [NADPH] 1
S-nitrosoglutathione reductase
T70518
PG-9-KR

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002198
Human Readable Name	SHORT CHAIN DEHYDROGENASE REDUCTASE
Interpro Short Name	DH_sc/Rdtase_SDR
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Name	Short-chain dehydrogenase/reductase SDR
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:

Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
Bains OS et al., 2009, Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin., Drug Metab Dispos
Gonzalez-Covarrubias V et al., 2009, Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors., Drug Metab Dispos
Lal S et al., 2008, CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients., Cancer Sci

N6022 CBR1

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DOXORUBICIN CBR1

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21048526 19204081 19022938 19016765

Sources:
PharmGKB
DAUNORUBICIN CBR1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19204081

Sources:
PharmGKB
CYCLOPHOSPHAMIDE CBR1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUOROURACIL CBR1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000159228
- Version: 101_38
Alternate Names:

CBR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000159228

Version: 26-July-2011

Alternate Names:

CBR1 Display Id

ENSG00000159228 Ensembl Gene Id

CARBONYL REDUCTASE [NADPH] 1 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 1) (PROSTAGLANDIN-E(2) 9-REDUCTASE) (EC 1.1.1.189) (PROSTAGLANDIN 9-KETOREDUCTASE) (15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NADP+]) (EC 1.1.1.197). [SOURCE:UNIPROT/SWISSPROT;AC Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P16152
- Version: 11-September-2012
Alternate Names:

873 Entrez Gene Id

P16152 Uniprot Accession

ENSG00000159228 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE

Interpro Short Name DH_sc/Rdtase_SDR

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:

PharmGKB: CBR1

Version: 18-August-2020

Alternate Names:

PA26121 PharmGKB ID

Gene Info:

Publications:

Blanco JG et al., 2012, Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group., J Clin Oncol

Lal S et al., 2008, CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients., Cancer Sci

Bains OS et al., 2009, Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin., Drug Metab Dispos

HingoraniCasas: ENSG00000159228
- Version: 31-May-2017
Alternate Names:

ENSG00000159228 Gene Symbol

CBR1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: S-nitrosoglutathione reductase
- Version: 2020.06.01
Alternate Names:

CBR1 TTD Gene Abbreviation

T70518 TTD Target ID

Gene Info:

Publications:

CBR1	Display Id
ENSG00000159228	Ensembl Gene Id
CARBONYL REDUCTASE [NADPH] 1 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 1) (PROSTAGLANDIN-E(2) 9-REDUCTASE) (EC 1.1.1.189) (PROSTAGLANDIN 9-KETOREDUCTASE) (15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NADP+]) (EC 1.1.1.197). [SOURCE:UNIPROT/SWISSPROT;AC	Description

873	Entrez Gene Id
P16152	Uniprot Accession
ENSG00000159228	Ensembl Gene Id

CBR1	TTD Gene Abbreviation
T70518	TTD Target ID

CBR1 Gene Record

CBR1 873 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

N6022 CBR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

DOXORUBICIN CBR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21048526 19204081 19022938 19016765

Sources: PharmGKB

DAUNORUBICIN CBR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19204081

Sources: PharmGKB

CYCLOPHOSPHAMIDE CBR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

FLUOROURACIL CBR1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000159228

Alternate Names: CBR1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000159228

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P16152

Alternate Names: 873 Entrez Gene Id P16152 Uniprot Accession ENSG00000159228 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE Interpro Short Name DH_sc/Rdtase_SDR

Gene Categories: DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:

PharmGKB: CBR1

Alternate Names: PA26121 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000159228

Alternate Names: ENSG00000159228 Gene Symbol CBR1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: S-nitrosoglutathione reductase

Alternate Names: CBR1 TTD Gene Abbreviation T70518 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21048526 19204081 19022938 19016765

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19204081

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

CBR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

873 Entrez Gene Id

P16152 Uniprot Accession

ENSG00000159228 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE

Interpro Short Name DH_sc/Rdtase_SDR

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Alternate Names:

PA26121 PharmGKB ID

Alternate Names:

ENSG00000159228 Gene Symbol

CBR1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CBR1 TTD Gene Abbreviation

T70518 TTD Target ID