• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CBR3 Gene Record

  • Summary
  • Interactions
  • Claims
  • CBR3 874 Druggable Genome

    Alternate Names:

    874
    CARBONYL REDUCTASE 3
    CBR3
    HEL-S-25
    SDR21C2
    hCBR3
    603608
    1549
    ENSG00000159231
    OTTHUMG00000086617
    O75828
    CBR3_HUMAN
    CARBONYL REDUCTASE [NADPH] 3
    CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828]
    PA26122

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002198
    Uniprot Status Swiss-Prot
    Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name DH_sc/Rdtase_SDR
    Interpro Name Short-chain dehydrogenase/reductase SDR
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    SHORT CHAIN DEHYDROGENASE REDUCTASE
    ENZYME

    Publications:

    Bains OS et al., 2010, Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism., J Pharmacol Exp Ther
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
    Fan L et al., 2008, Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity., Pharmacogenet Genomics
  • DOXORUBICIN   CBR3

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21048526 20007405 18551042


    Sources:
    PharmGKB

  • EPIRUBICIN   CBR3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DAUNORUBICIN   CBR3

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20007405


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   CBR3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUOROURACIL   CBR3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000159231

    • Version: 101_38

    Alternate Names:
    CBR3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: O75828

    • Version: 11-September-2012

    Alternate Names:
    CBR3 Uniprot Gene Name
    CBR3_HUMAN Uniprot Id
    874 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002198
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

    Publications:

  • RussLampel: ENSG00000159231

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000159231 Ensembl Gene Id
    CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828] Description
    CBR3 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: CBR3

    • Version: 18-August-2020

    Alternate Names:
    PA26122 PharmGKB ID

    Gene Info:

    Publications:
    Blanco JG et al., 2008, Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer., Cancer
    Bains OS et al., 2010, Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism., J Pharmacol Exp Ther
    Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics

  • HingoraniCasas: ENSG00000159231

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000159231 Gene Symbol
    CBR3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: CBR3

    • Version: 11-November-2018

    Alternate Names:
    CBR3 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: CBR3

    • Version: 01-February-2022

    Alternate Names:
    Carbonyl reductase [NADPH] 3 Gene Name
    O75828 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21