DGIdb - CBR3 Gene Record

CBR3 874 Druggable Genome

Alternate Names:

874
CARBONYL REDUCTASE 3
CBR3
HEL-S-25
SDR21C2
hCBR3
603608
1549
ENSG00000159231
OTTHUMG00000086617
O75828
CBR3_HUMAN
CARBONYL REDUCTASE [NADPH] 3
CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828]
PA26122

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002198
Uniprot Status	Swiss-Prot
Human Readable Name	SHORT CHAIN DEHYDROGENASE REDUCTASE
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	DH_sc/Rdtase_SDR
Interpro Name	Short-chain dehydrogenase/reductase SDR
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
SHORT CHAIN DEHYDROGENASE REDUCTASE
ENZYME

Publications:

Bains OS et al., 2010, Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism., J Pharmacol Exp Ther
Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics
Fan L et al., 2008, Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity., Pharmacogenet Genomics

DOXORUBICIN CBR3

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21048526 20007405 18551042

Sources:
PharmGKB
EPIRUBICIN CBR3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DAUNORUBICIN CBR3

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20007405

Sources:
PharmGKB
CYCLOPHOSPHAMIDE CBR3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUOROURACIL CBR3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000159231
- Version: 101_38
Alternate Names:

CBR3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: O75828
- Version: 11-September-2012
Alternate Names:

CBR3 Uniprot Gene Name

CBR3_HUMAN Uniprot Id

874 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR002198

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:

RussLampel: ENSG00000159231

Version: 26-July-2011

Alternate Names:

ENSG00000159231 Ensembl Gene Id

CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828] Description

CBR3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: CBR3

Version: 18-August-2020

Alternate Names:

PA26122 PharmGKB ID

Gene Info:

Publications:

Blanco JG et al., 2008, Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer., Cancer

Bains OS et al., 2010, Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism., J Pharmacol Exp Ther

Thorn CF et al., 2011, Doxorubicin pathways: pharmacodynamics and adverse effects., Pharmacogenet Genomics

HingoraniCasas: ENSG00000159231
- Version: 31-May-2017
Alternate Names:

ENSG00000159231 Gene Symbol

CBR3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: CBR3
- Version: 11-November-2018
Alternate Names:

CBR3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: CBR3
- Version: 01-February-2022
Alternate Names:

Carbonyl reductase [NADPH] 3 Gene Name

O75828 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000159231	Ensembl Gene Id
CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828]	Description
CBR3	Display Id

CBR3 Gene Record

CBR3 874 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DOXORUBICIN CBR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21048526 20007405 18551042

Sources: PharmGKB

EPIRUBICIN CBR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

DAUNORUBICIN CBR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20007405

Sources: PharmGKB

CYCLOPHOSPHAMIDE CBR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

FLUOROURACIL CBR3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000159231

Alternate Names: CBR3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: O75828

Alternate Names: CBR3 Uniprot Gene Name CBR3_HUMAN Uniprot Id 874 Entrez Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Acc IPR002198 Uniprot Status Swiss-Prot

Gene Categories: DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:

RussLampel: ENSG00000159231

Alternate Names: ENSG00000159231 Ensembl Gene Id CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828] Description CBR3 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: CBR3

Alternate Names: PA26122 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000159231

Alternate Names: ENSG00000159231 Gene Symbol CBR3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: CBR3

Alternate Names: CBR3 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: CBR3

Alternate Names: Carbonyl reductase [NADPH] 3 Gene Name O75828 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21048526 20007405 18551042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20007405

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

CBR3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CBR3 Uniprot Gene Name

CBR3_HUMAN Uniprot Id

874 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR002198

Uniprot Status Swiss-Prot

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Alternate Names:

ENSG00000159231 Ensembl Gene Id

CARBONYL REDUCTASE [NADPH] 3 (EC 1.1.1.184) (NADPH-DEPENDENT CARBONYL REDUCTASE 3). [SOURCE:UNIPROT/SWISSPROT;ACC:O75828] Description

CBR3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA26122 PharmGKB ID

Alternate Names:

ENSG00000159231 Gene Symbol

CBR3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CBR3 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Carbonyl reductase [NADPH] 3 Gene Name

O75828 UniProt ID

Gene Categories:

ENZYME