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CCN2 Gene Record

  • Summary
  • Interactions
  • Claims
  • CCN2 1490 Druggable Genome

    Alternate Names:

    1490
    CONNECTIVE TISSUE GROWTH FACTOR
    CTGF
    CCN2
    HCS24
    IGFBP8
    NOV2
    121009
    2500
    ENSG00000118523
    OTTHUMG00000015573
    IGFBP-8
    CCN family member 2
    Hypertrophic chondrocyte-specific protein 24
    Insulin-like growth factor-binding protein 8
    IGF-binding protein 8
    IBP-8
    P29279
    T50444
    CELLULAR COMMUNICATION NETWORK FACTOR 2

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass growth factor
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Chambers et al., 2000, Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1., J. Biol. Chem.
    Wang et al., 2008, [Effect of enalapil on renal interstitial fibrosis in rats with unilateral ureteral obstruction]., Zhong Nan Da Xue Xue Bao Yi Xue Ban
    Rimon et al., 2008, Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor., Endocrinology
    Vorwerk et al., 2002, Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor., Endocrinology
    Gross et al., 2004, Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis., Nephrol. Dial. Transplant.
    Buchhorn et al., 2003, Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease., Cardiol Young
    Schild et al., 2004, Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress., Biochim. Biophys. Acta
    Chowdhury et al., 2004, Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics., Eur. J. Biochem.
    Shin et al., 2005, Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin., J. Invest. Dermatol.
    Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
    Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology
    Kidd et al., 2007, Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development., Am. J. Physiol. Gastrointest. Liver Physiol.
    Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.
    Harlow et al., 2007, Oestrogen formation and connective tissue growth factor expression in rat granulosa cells., J. Endocrinol.
    Ehrchen et al., 2001, Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary., J. Endocrinol.
    Gauer et al., 2007, Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor., Nephrol. Dial. Transplant.
  • ACRIDINE   CCN2

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16950763


    Sources:
    NCI

  • PAMREVLUMAB   CCN2

    Interaction Score: 6.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name FG-3019 , anti-CTGF
    Mechanism of Interaction Connective tissue growth factor inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • RAMIPRIL   CCN2

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15128880


    Sources:
    NCI

  • OCAPERIDONE   CCN2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • 2-METHOXYESTRADIOL   CCN2

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18292194


    Sources:
    NCI

  • VITAMIN E   CCN2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12023009


    Sources:
    NCI

  • INOSITOL   CCN2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15560785


    Sources:
    NCI

  • PROPRANOLOL   CCN2

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12691286


    Sources:
    NCI

  • PRASTERONE   CCN2

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15675949


    Sources:
    NCI

  • SPIRONOLACTONE   CCN2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17602195


    Sources:
    NCI

  • ENALAPRIL   CCN2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18812665


    Sources:
    NCI

  • ANDROSTANOLONE   CCN2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11181522


    Sources:
    NCI

  • THROMBIN   CCN2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10952976


    Sources:
    NCI

  • STAUROSPORINE   CCN2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15053922


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   CCN2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11250650


    Sources:
    NCI

  • ESTRADIOL   CCN2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17210741


    Sources:
    NCI

  • DIGOXIN   CCN2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12691286


    Sources:
    NCI

  • INSULIN   CCN2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11956149


    Sources:
    NCI

  • CURCUMIN   CCN2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16306131


    Sources:
    NCI

  • Ensembl: ENSG00000118523

    • Version: 101_38

    Alternate Names:
    CCN2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P29279

    • Version: January-2014

    Alternate Names:
    CTGF Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Ligand
    Target Subclass growth factor

    Publications:

  • TTD: Connective tissue growth factor

    • Version: 2020.06.01

    Alternate Names:
    CTGF TTD Gene Abbreviation
    T50444 TTD Target ID

    Gene Info:

    Publications:
    Cheng TY et al., 2014, Cyr61/CTGF/Nov family proteins in gastric carcinogenesis., World J Gastroenterol

  • NCI: CTGF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology
    Lee et al., 2005, Advanced glycation end-product-induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK-49F cells., J. Cell. Biochem.
    Goulet et al., 2007, Opposite effect of corticosteroids and long-acting beta(2)-agonists on serum- and TGF-beta(1)-induced extracellular matrix deposition by primary human lung fibroblasts., J. Cell. Physiol.

  • HingoraniCasas: ENSG00000118523

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000118523 Gene Symbol
    CTGF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CCN2

    • Version: chembl_23

    Alternate Names:
    HCS24 GENE_SYMBOL
    IGFBP8 GENE_SYMBOL
    CTGF GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: CCN2

    • Version: 01-February-2022

    Alternate Names:
    CTGF GO Gene Synonym
    HCS24 GO Gene Synonym
    IGFBP8 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21