DGIdb - CCN2 Gene Record

CCN2 1490 Druggable Genome

Alternate Names:

1490
CONNECTIVE TISSUE GROWTH FACTOR
CTGF
CCN2
HCS24
IGFBP8
NOV2
121009
2500
ENSG00000118523
OTTHUMG00000015573
IGFBP-8
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
IGF-binding protein 8
IBP-8
P29279
T50444
CELLULAR COMMUNICATION NETWORK FACTOR 2

Gene Info:

Target Class	Miscellaneous
Target Subclass	Ligand
Target Subclass	growth factor
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUGGABLE GENOME

Publications:

Chambers et al., 2000, Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1., J. Biol. Chem.
Wang et al., 2008, [Effect of enalapil on renal interstitial fibrosis in rats with unilateral ureteral obstruction]., Zhong Nan Da Xue Xue Bao Yi Xue Ban
Rimon et al., 2008, Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor., Endocrinology
Vorwerk et al., 2002, Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor., Endocrinology
Gross et al., 2004, Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosis., Nephrol. Dial. Transplant.
Buchhorn et al., 2003, Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease., Cardiol Young
Schild et al., 2004, Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress., Biochim. Biophys. Acta
Chowdhury et al., 2004, Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics., Eur. J. Biochem.
Shin et al., 2005, Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin., J. Invest. Dermatol.
Azzi et al., 2002, Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)., FEBS Lett.
Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology
Kidd et al., 2007, Role of CCN2/CTGF in the proliferation of Mastomys enterochromaffin-like cells and gastric carcinoid development., Am. J. Physiol. Gastrointest. Liver Physiol.
Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.
Harlow et al., 2007, Oestrogen formation and connective tissue growth factor expression in rat granulosa cells., J. Endocrinol.
Ehrchen et al., 2001, Expression and regulation of osteopontin and connective tissue growth factor transcripts in rat anterior pituitary., J. Endocrinol.
Gauer et al., 2007, Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor., Nephrol. Dial. Transplant.

ACRIDINE CCN2

Interaction Score: 6.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16950763

Sources:
NCI
PAMREVLUMAB CCN2

Interaction Score: 6.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name FG-3019 , anti-CTGF

Mechanism of Interaction Connective tissue growth factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RAMIPRIL CCN2

Interaction Score: 1.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15128880

Sources:
NCI
2-METHOXYESTRADIOL CCN2

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18292194

Sources:
NCI
VITAMIN E CCN2

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12023009

Sources:
NCI
OCAPERIDONE CCN2

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INOSITOL CCN2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15560785

Sources:
NCI
PROPRANOLOL CCN2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12691286

Sources:
NCI
PRASTERONE CCN2

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15675949

Sources:
NCI
SPIRONOLACTONE CCN2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17602195

Sources:
NCI
ENALAPRIL CCN2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18812665

Sources:
NCI
ANDROSTANOLONE CCN2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11181522

Sources:
NCI
THROMBIN CCN2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10952976

Sources:
NCI
LIOTHYRONINE SODIUM CCN2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11250650

Sources:
NCI
ESTRADIOL CCN2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17210741

Sources:
NCI
DIGOXIN CCN2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12691286

Sources:
NCI
STAUROSPORINE CCN2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15053922

Sources:
NCI
INSULIN CCN2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11956149

Sources:
NCI
CURCUMIN CCN2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16306131

Sources:
NCI

Ensembl: ENSG00000118523
- Version: 101_38
Alternate Names:

CCN2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P29279
- Version: January-2014
Alternate Names:

CTGF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass growth factor

Publications:
TTD: Connective tissue growth factor
- Version: 2020.06.01
Alternate Names:

CTGF TTD Gene Abbreviation

T50444 TTD Target ID

Gene Info:

Publications:

Cheng TY et al., 2014, Cyr61/CTGF/Nov family proteins in gastric carcinogenesis., World J Gastroenterol

NCI: CTGF

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology

Lee et al., 2005, Advanced glycation end-product-induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK-49F cells., J. Cell. Biochem.

Goulet et al., 2007, Opposite effect of corticosteroids and long-acting beta(2)-agonists on serum- and TGF-beta(1)-induced extracellular matrix deposition by primary human lung fibroblasts., J. Cell. Physiol.

HingoraniCasas: ENSG00000118523
- Version: 31-May-2017
Alternate Names:

ENSG00000118523 Gene Symbol

CTGF Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CCN2
- Version: chembl_23
Alternate Names:

HCS24 GENE_SYMBOL

IGFBP8 GENE_SYMBOL

CTGF GENE_SYMBOL

Gene Info:

Publications:
GO: CCN2
- Version: 01-May-2021
Alternate Names:

CTGF GO Gene Synonym

HCS24 GO Gene Synonym

IGFBP8 GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:

Novel drug target	Novel Target
Trial Name	FG-3019 , anti-CTGF
Mechanism of Interaction	Connective tissue growth factor inhibitor

CTGF	GO Gene Synonym
HCS24	GO Gene Synonym
IGFBP8	GO Gene Synonym

CCN2 Gene Record

CCN2 1490 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16950763

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name FG-3019 , anti-CTGF Mechanism of Interaction Connective tissue growth factor inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15128880

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18292194

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12023009

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15560785

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12691286

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15675949

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17602195

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18812665

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11181522

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10952976

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11250650

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17210741

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12691286

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15053922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11956149

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
16950763

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name FG-3019 , anti-CTGF

Mechanism of Interaction Connective tissue growth factor inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15128880

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18292194

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12023009

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
15560785

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12691286

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15675949

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17602195

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18812665

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11181522

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10952976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11250650

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17210741

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12691286

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15053922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11956149

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16306131

Sources:
NCI

Alternate Names:

CCN2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CTGF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass growth factor

Alternate Names:

CTGF TTD Gene Abbreviation

T50444 TTD Target ID

Publications:

Cheng TY et al., 2014, Cyr61/CTGF/Nov family proteins in gastric carcinogenesis., World J Gastroenterol

Alternate Names:

ENSG00000118523 Gene Symbol

CTGF Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HCS24 GENE_SYMBOL

IGFBP8 GENE_SYMBOL

CTGF GENE_SYMBOL

Alternate Names:

CTGF GO Gene Synonym

HCS24 GO Gene Synonym

IGFBP8 GO Gene Synonym

Gene Categories:

GROWTH FACTOR