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CCNE1 Gene Record

  • Summary
  • Interactions
  • Claims
  • CCNE1 898 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    898
    CYCLIN E1
    CCNE1
    CCNE
    pCCNE1
    123837
    1589
    ENSG00000105173
    OTTHUMG00000177626
    11
    G1/S-specific cyclin-E1
    P24864

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUG RESISTANCE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Au-Yeung et al., 2017, Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition., Clin. Cancer Res.
    Herrera-Abreu et al., 2016, Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer., Cancer Res.
    Taylor-Harding B et al., 2015, Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS., Oncotarget
    Turner NC et al., 2019, Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer., J Clin Oncol
  • DINACICLIB   CCNE1

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27663592


    Sources:
    ClearityFoundationBiomarkers CIViC

  • AMG-900   CCNE1

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • FULVESTRANT   CCNE1

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30807234


    Sources:
    CIViC

  • PALBOCICLIB   CCNE1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27020857 25557169 30807234


    Sources:
    CIViC

  • ALISERTIB   CCNE1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers

  • Ensembl: ENSG00000105173

    • Version: 101_38

    Alternate Names:
    CCNE1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: CCNE1

    • Version: 14-September-2020

    Alternate Names:
    898 Entrez Gene ID
    11 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Taylor-Harding B et al., 2015, Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS., Oncotarget
    Herrera-Abreu et al., 2016, Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer., Cancer Res.
    Turner NC et al., 2019, Cyclin E1 Expression and Palbociclib Efficacy in Previously Treated Hormone Receptor-Positive Metastatic Breast Cancer., J Clin Oncol

  • HingoraniCasas: ENSG00000105173

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105173 Gene Symbol
    CCNE1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: CCNE1

    • Version: 01-February-2022

    Alternate Names:
    CCNE GO Gene Synonym

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • Tempus: CCNE1

    • Version: 11-November-2018

    Alternate Names:
    CCNE1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: CCNE1

    • Version: 01-February-2022

    Alternate Names:
    G1/S-specific cyclin-E1 Gene Name
    P24864 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: CCNE1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • ClearityFoundationBiomarkers: CCNE1

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • FoundationOneGenes: CCNE1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CCNE1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: CCNE1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21