• Interaction Score: 17.4

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name MLN-1202
    Novel drug target Novel Target
    Direct Interaction? True

  • Interaction Score: 17.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction C-C chemokine receptor type 2 antagonist
    Direct Interaction yes
    Trial Name CCX140

    PMIDs:
    None found


  • Interaction Score: 17.4

    Interaction Types & Directionality:
    allosteric modulator
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction C-C chemokine receptor type 2 antagonist
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 8.7

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    17715128


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction C-C chemokine receptor type 2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction C-C chemokine receptor type 2 antagonist
    Details of the Assay for Interaction Whole cell binding assay measuring displacement of [125I]MCP-1 from CCR2 by PF-04634817 in human peripheral blood mononuclear cells.

    PMIDs:
    None found


  • Interaction Score: 5.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17715128


    Sources:
    DTC

  • Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16831471


    Sources:
    NCI

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15781755


    Sources:
    NCI