DGIdb - CD28 Gene Record

CD28 940 Druggable Genome

Alternate Names:

940
CD28 MOLECULE
CD28
Tp44
186760
1653
ENSG00000178562
OTTHUMG00000132878
P10747
T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28
T85529

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	T-cell surface receptor
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Nakamura et al., 2001, Positive effect on T-cell regulatory apoptosis by mycophenolate mofetil., Clin Transplant
Ledbetter et al., 1990, CD28 ligation in T-cell activation: evidence for two signal transduction pathways., Blood
Schnaider et al., 1998, The Hsp90-specific inhibitor, geldanamycin, blocks CD28-mediated activation of human T lymphocytes., Life Sci.
Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A

BENZODEPA CD28

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL445304 CD28

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18003900

Sources:
DTC
BELATACEPT CD28

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GELDANAMYCIN CD28

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9747895

Sources:
NCI
ALDESLEUKIN CD28

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2156582

Sources:
NCI
PROGESTERONE CD28

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11903384

Sources:
NCI

Ensembl: ENSG00000178562
- Version: 101_38
Alternate Names:

CD28 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P10747
- Version: January-2014
Alternate Names:

CD28 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Publications:

NCI: CD28

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Grosse-Hovest et al., 1999, Tumor-growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: the role of targeted T-cell co-stimulation via CD28., Int. J. Cancer

Watanabe et al., 2004, Adenovirus-mediated CTLA4 immunoglobulin G gene therapy in cardiac xenotransplantation., Transplant. Proc.

Heise et al., 2001, B7.1 expression eliminates tumor resistance to IL-12 gene therapy., Cancer Gene Ther.

DTC: CD28
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A
HingoraniCasas: ENSG00000178562
- Version: 31-May-2017
Alternate Names:

ENSG00000178562 Gene Symbol

CD28 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: T-cell-specific surface glycoprotein CD28
- Version: 2020.06.01
Alternate Names:

CD28 TTD Gene Abbreviation

T85529 TTD Target ID

Gene Info:

Publications:
Pharos: CD28
- Version: 01-February-2022
Alternate Names:

T-cell-specific surface glycoprotein CD28 Gene Name

P10747 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: CD28
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

T-cell-specific surface glycoprotein CD28	Gene Name
P10747	UniProt ID

CD28 Gene Record

CD28 940 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

BENZODEPA CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

CHEMBL445304 CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18003900

Sources: DTC

BELATACEPT CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

GELDANAMYCIN CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9747895

Sources: NCI

ALDESLEUKIN CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2156582

Sources: NCI

PROGESTERONE CD28

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11903384

Sources: NCI

Ensembl: ENSG00000178562

Alternate Names: CD28 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P10747

Alternate Names: CD28 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass T-cell surface receptor

Publications:

NCI: CD28

Alternate Names:

Gene Info:

DTC: CD28

Alternate Names:

Gene Info:

Publications: Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A

HingoraniCasas: ENSG00000178562

Alternate Names: ENSG00000178562 Gene Symbol CD28 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: T-cell-specific surface glycoprotein CD28

Alternate Names: CD28 TTD Gene Abbreviation T85529 TTD Target ID

Gene Info:

Publications:

Pharos: CD28

Alternate Names: T-cell-specific surface glycoprotein CD28 Gene Name P10747 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: CD28

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
18003900

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9747895

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2156582

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11903384

Sources:
NCI

Alternate Names:

CD28 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CD28 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass T-cell surface receptor

Publications:

Hayashi T et al., 2007, 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis., Proc Natl Acad Sci U S A

Alternate Names:

ENSG00000178562 Gene Symbol

CD28 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD28 TTD Gene Abbreviation

T85529 TTD Target ID

Alternate Names:

T-cell-specific surface glycoprotein CD28 Gene Name

P10747 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE