• Interaction Score: 12.76

    Interaction Types & Directionality:
    antibody (inhibitory)
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor
    Direct Interaction yes
    Trial Name -

  • Interaction Score: 6.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 6.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain other
    Trial Name teplizumab, MGA03

    PMIDs:
    None found


  • Interaction Score: 6.38

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Binding

  • Interaction Score: 4.78

    Interaction Types & Directionality:
    agonist (activating)
    antibody (inhibitory)

    Interaction Info:
    Trial Name catumaxomab,Removab
    Novel drug target Established target
    Specific Action of the Ligand Binding

  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Nuvion
    Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain inhibitor

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name NI-0401
    Novel drug target Established target
    Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain other
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 2.73

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Mechanism of Interaction T cell surface glycoprotein CD3 cross-linking agent
    Direct Interaction yes
    Details of the Assay for Interaction Binding of the single-chain Fv portion of blinatumomab to CD3.

  • Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name MT110

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

    • Version: 101_38

    Alternate Names:
    CD3E Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    916 Entrez Gene Id
    CD3E_HUMAN Uniprot Id
    ENSG00000198851 Ensembl Gene Id

    Gene Info:
    Transmembrane Helix Count 1
    Target Main Class Receptors
    Target Subclass Other

    Publications:

    • Version: January-2014

    Alternate Names:
    CD3E Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass T-cell receptor subunit

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    1674 HUGO Gene ID
    1674 HUGO Gene Symbol
    CD3e molecule HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CD molecules
    GuideToPharmacology Gene Category ID 852

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198851 Gene Symbol
    CD3E Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    T3E GENE_SYMBOL
    CD3E GENE_SYMBOL
    T-cell surface glycoprotein CD3 epsilon chain UNIPROT

    Gene Info:

    Publications:

  • Alternate Names:
    CD3E TTD Gene Abbreviation
    T87075 TTD Target ID

    Gene Info:

    Publications:

  • GO: CD3E

    • Version: 01-May-2021

    Alternate Names:
    T3E GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    T-cell surface glycoprotein CD3 epsilon chain Gene Name
    P07766 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: