• Interaction Score: 28.35

    Interaction Types & Directionality:
    agonist (activating)
    antibody (inhibitory)

    Interaction Info:
    Trial Name BT-061
    Novel drug target Established target
    Specific Action of the Ligand Binding

  • Interaction Score: 21.26

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Binding

    PMIDs:
    None found


  • Interaction Score: 21.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name zanolimumab, HuMax-CD4
    Novel drug target Established target
    Mechanism of Interaction T-cell surface antigen CD4 other

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1833207


    Sources:
    NCI

  • Interaction Score: 7.09

    Interaction Types & Directionality:
    negative modulator (inhibitory)

    Interaction Info:
    Mechanism of Interaction T-cell surface antigen CD4 negative modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction T-cell surface antigen CD4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction T-cell surface antigen CD4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction T-cell surface antigen CD4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 7.09

    Interaction Types & Directionality:
    negative modulator (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction T-cell surface antigen CD4 negative modulator

    PMIDs:
    None found